Microfabricated Compositions and Processes for Engineering Tissues Containing Multiple Cell Types

• US 20070281353A1
• Filed: 05/21/2004
• Published: 12/06/2007
• Est. Priority Date: 05/21/2003
• Status: Active Grant

• Current Assignee: Charles Stark Draper Laboratory Incorporated, The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: Charles Stark Draper Laboratory Incorporated
• Inventors: Weinberg, Eli, Borenstein, Jeffrey, Vacanti, Joseph
• Granted Patent: US 7,960,166 B2
• Time in Patent Office: Days
• US Class Current: 435/367
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: C12N 2533/40 Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
• CPC Class Codes: C12N 5/0062 General methods for three-dimensional culture
• CPC Class Codes: C12N 5/0068 General culture methods using substrates for specific animal cell type C12N5/06
• CPC Class Codes: C12N 5/0697 Artificial constructs associating cells of different lineages, e.g. tissue equivalents blood vessels C12N5/0691

Abstract

The present invention relates to a three-dimensional system, and compositions obtained therefrom, wherein individual layers of the system comprise channels divided longitudinally into two compartments by a centrally positioned membrane, and wherein each compartment can comprise a different cell type.

Claims

36-1. The device of claim 36, wherein the device is extracorporeal.