Techniques for Determining Glucose Levels
First Claim
1. A device for measuring a glucose level in a living body, said device comprising a sensor arrangement (5, 6) to be applied to a surface of the body, processing circuitry (31-33, 37, 38) for measuring a response of the sensor arrangement and deriving the glucose level therefrom, and at least a first and a second temperature sensor (15, 22) wherein a signal of the first temperature sensor depends in different manner on a skin temperature of the body and on an environmental temperature than a signal of the second sensor.
3 Assignments
0 Petitions
Accused Products
Abstract
A device (100) for measuring the glucose level in a living body comprises an electrode arrangement (5, 6) to be applied to a surface of the body. The glucose level is derived from the response of the electrode arrangement (5, 6) to an electrical signal. Two temperature sensors (15, 22) are arranged at different positions within the device (100), the signals of which are used during calibration and measurements to improve the accuracy of the device. A further increase of accuracy is achieved by using an interpolation method during calibration. In addition, caused by a displacement of the device are applied. The device can also be used for a prediction of hyper- or hypoglycemia based on limits for the higher order derivatives of the glucose level.
-
Citations
41 Claims
-
1. A device for measuring a glucose level in a living body, said device comprising
a sensor arrangement (5, 6) to be applied to a surface of the body, processing circuitry (31-33, 37, 38) for measuring a response of the sensor arrangement and deriving the glucose level therefrom, and at least a first and a second temperature sensor (15, 22) wherein a signal of the first temperature sensor depends in different manner on a skin temperature of the body and on an environmental temperature than a signal of the second sensor.
-
26. A method for measuring a glucose level in a living body comprising the steps of
applying a sensor arrangement (5, 6) to a surface of the body, measuring a response of the sensor arrangement and deriving at least one first value (A0, f0) therefrom, measuring at least a second and a third value (T1, T2) with a first and a second temperature sensor (15, 22), wherein the second value (T1) depends in different manner on a skin temperature of the body and on an environmental temperature than the third value (T2), calculating from said first, second and third values (A0, f0; - T1;
T2) said glucose level using calibration parameters (a0 . . . aM). - View Dependent Claims (38, 39, 40)
- T1;
-
27. A method for operating a device for measuring a glucose level in a living body, said device comprising a sensor arrangement (5, 6) to be applied to a surface of the body, and processing circuitry (31-33, 37, 38) for measuring a response of the sensor arrangement and deriving the glucose level therefrom, wherein said processing circuitry (31-33, 37, 38) is adapted for calculating the glucose level g from
g=F(s1, s2, . . . sN, a0, a1, . . . aM),where F is a function depending on N≧ - 1 measured input values s1 . . . sN, wherein the function F has M+1 calibration parameters a1, . . . aM with M≦
0, wherein said method comprises the steps of;
detecting a displacement of the device in respect to the body, determine an effect of the shift on the measured glucose level, and correcting the measured glucose levels after the shift to compensate for the determined effect. - View Dependent Claims (28, 29, 30, 41)
- 1 measured input values s1 . . . sN, wherein the function F has M+1 calibration parameters a1, . . . aM with M≦
-
31. A method for calibrating a device for measuring a glucose level in a living body, said device comprising a sensor arrangement (5, 6) to be applied to a surface of the body and processing circuitry (31-33, 37, 38) for measuring a response of the sensor arrangement and deriving the glucose level therefrom, wherein said processing circuitry (31-33, 37, 38) is adapted for calculating the glucose level g from
g=F(s1,s2, . . . sN, a0, a1, . . . aM),where F is a function depending on N≧ - 1 measured input values s1, . . . sN, wherein the function F has M+1 calibration parameters a1, . . . aM with M≧
0, andsaid method comprising the step deriving at least part of said parameters ai from a series of input values sj(t′
i) recorded at times t′
i in a given calibration phase and a series of reference values g(ti) measured at times ti in the calibration phase by comparing values obtained by function F against the reference values or against values derived from the reference values. - View Dependent Claims (32, 33, 34, 35, 36)
- 1 measured input values s1, . . . sN, wherein the function F has M+1 calibration parameters a1, . . . aM with M≧
-
37. A method for predicting the glucose level in a living body comprising the steps of
measuring the glucose level g(t) repetitively, predicting a future glucose level from an estimate of the current value of the glucose level g(t) as i well as its derivative {dot over (g)}(t), taking into account that the prediction must fulfil the conditions
{dot over (g)}≧- −
{dot over (g)}decr and {umlaut over (g)}≧
−
{umlaut over (g)}−
and/or
{dot over (g)}≧
{dot over (g)}incr and {umlaut over (g)}≧
{umlaut over (g)}+.
- −
Specification