Implantable wireless sensor for in vivo pressure measurement and continuous output determination

• US 20070282210A1
• Filed: 05/04/2007
• Published: 12/06/2007
• Est. Priority Date: 05/04/2006
• Status: Abandoned Application

• Current Assignee: CardioMEMS Incorporated
• Original Assignee: CardioMEMS Incorporated
• Inventors: Stern, David
• Application Number:
  US11/800,442
• Publication Number:
  US 20070282210A1
• Time in Patent Office: Days
• US Class Current: 600/486
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00

Abstract

A method and apparatus for determining cardiac parameters within the body of a patient includes a wireless sensor positioned in the patient'"'"'s pulmonary artery. An external RF telemetry device communicates wirelessly with the sensor and interrogates the sensor to determine changes in pressure in the pulmonary artery over time. The peak pressure difference is determined. Then, assuming zero blood flow velocity at the time of valve opening and at the time of valve closing, a velocity-time function is determined. The velocity-time function is used to determine a velocity-time integral. The velocity-time integral is then used to determine cardiac stroke volume. The cardiac stroke volume is multiplied times the heartbeat rate to determine cardiac output. The cardiac output can be monitored over time to determine continuous cardiac output.

Claims

1. A method for determining cardiac stroke volume in a patient, comprising the steps of:

positioning a wireless sensor in the patient'"'"'s pulmonary artery;

interrogating the wireless sensor to determine changes in pressure in the pulmonary artery over time;

determining the peak pressure difference;

assuming zero blood flow velocity at the time of valve opening and at the time of valve closing, determining a velocity-time function;

using the velocity-time function to determine a velocity-time integral; and

using the velocity-time integral to determine cardiac stroke volume.

2. The method of claim 1, wherein said step of determining the velocity-time function is accomplished by using the formula Δ

P_(PEAK)=4*V₂², where Δ

P_(PEAK) is the peak pressure difference and V₂ is the peak velocity.

3. The method of claim 1, wherein said step of using the velocity-time integral to determine cardiac stroke volume is accomplished by multiplying the cross-sectional area of the outflow tract times the velocity-time integral.

4. A method for determining cardiac output in a patient, comprising the steps of:

positioning a wireless sensor in the patient'"'"'s pulmonary artery;

interrogating the wireless sensor to determine changes in pressure in the pulmonary artery over time;

determining the peak pressure difference;

assuming zero blood flow velocity at the time of valve opening and at the time of valve closing, determining a velocity-time function;

using the velocity-time function to determine a velocity-time integral;

using the velocity-time integral to determine cardiac stroke volume; and

multiplying the cardiac stroke volume times the heartbeat rate to determine cardiac output.

5. The method of claim 4, wherein said step of determining the velocity-time function is accomplished by using the formula Δ

P_(PEAK)=4*V₂², where Δ

P_(PEAK) is the peak pressure difference and V₂ is the peak velocity.

6. The method of claim 4, wherein said step of using the velocity-time integral to determine cardiac stroke volume is accomplished by multiplying the cross-sectional area of the outflow tract times the velocity-time integral.

7. A method for determining continuous cardiac output in a patient, comprising the steps of:

positioning a wireless sensor in the patient'"'"'s pulmonary artery;

interrogating the wireless sensor to determine changes in pressure in the pulmonary artery over time;

determining the peak pressure difference;

assuming zero blood flow velocity at the time of valve opening and at the time of valve closing, determining a velocity-time function;

using the velocity-time function to determine a velocity-time integral;

using the velocity-time integral to determine cardiac stroke volume;

multiplying the cardiac stroke volume times the heartbeat rate to determine cardiac output; and

monitoring the cardiac output over time to determine continuous cardiac output.

8. The method of claim 7, wherein said step of determining the velocity-time function is accomplished by using the formula Δ

P_(PEAK)=4*V₂², where Δ

P_(PEAK) is the peak pressure difference and V₂ is the peak velocity.

9. The method of claim 7, wherein said step of using the velocity-time integral to determine cardiac stroke volume is accomplished by multiplying the cross-sectional area of the outflow tract times the velocity-time integral.

10. An apparatus for determining cardiac parameters in a patient, comprising:

a wireless sensor for positioning in the patient'"'"'s pulmonary artery;

an external RF telemetry apparatus for wirelessly coupling to said wireless sensor;

means associated with said telemetry apparatus for interrogating the wireless sensor over time to determine changes in pressure in the pulmonary artery over time;

means associated with the telemetry apparatus for determining the peak pressure difference;

means for determining a velocity-time function, assuming zero blood flow velocity at the time of valve opening and again at the time of valve closing;

means for determining a velocity-time integral from the velocity-time function; and

means for determining cardiac stroke volume from the velocity-time integral;

11. The apparatus of claim 10, further comprising a means for multiplying the cardiac stroke volume times the heartbeat rate to determine cardiac output.

12. The apparatus of claim 11, further comprising a means for monitoring the cardiac output over time to determine continuous cardiac output.