Drug and excipient aerosol compositions
First Claim
1. An aerosol generation device, comprising:
- a. a heatable filament; and
b. a composition coating the filament comprising a vaporizable carrier and a therapeutic agent;
wherein when the filament is heated to at least the vaporization point of the carrier, the carrier vaporizes and releases the therapeutic agent from the composition to thereby form an aerosol comprising the therapeutic agent and the carrier.
1 Assignment
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Accused Products
Abstract
The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 μm, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.
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Citations
56 Claims
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1. An aerosol generation device, comprising:
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a. a heatable filament; and
b. a composition coating the filament comprising a vaporizable carrier and a therapeutic agent;
wherein when the filament is heated to at least the vaporization point of the carrier, the carrier vaporizes and releases the therapeutic agent from the composition to thereby form an aerosol comprising the therapeutic agent and the carrier. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. An aerosol generation device, comprising:
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a. a heating element having a surface; and
b. a composition coating at least a portion of the heating element surface and comprising a carrier and a therapeutic agent;
wherein when the heating element surface is heated to at least the vaporization point of the carrier, the carrier vaporizes and releases the therapeutic agent from the composition to thereby form an aerosol comprising the therapeutic agent and the carrier. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
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38. A method of producing an aerosol, comprising:
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a. providing an aerosol generation device comprising;
i. a heating element having a surface; and
ii. a composition coating at least a portion of the heating element surface, the composition comprising a carrier and a therapeutic agent;
b. heating the surface of the heating element to vaporize the carrier and produce a heated vapor of the carrier and the therapeutic agent, thereby propelling the therapeutic agent from the surface of the heating element; and
c. cooling the vapor to condense the carrier and the compound into an aerosol. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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Specification