Amino acid compositions

• US 20070286909A1
• Filed: 06/07/2007
• Published: 12/13/2007
• Est. Priority Date: 06/07/2006
• Status: Abandoned Application

• Current Assignee: Daniel S. Smith
• Original Assignee: Daniel S. Smith
• Inventors: Kuss, Timothy, Ross, Julia, Smith, Daniel S.
• Application Number:
  US11/811,224
• Publication Number:
  US 20070286909A1
• Time in Patent Office: Days
• US Class Current: 424/682
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23L 33/16 Inorganic salts, minerals or trace elements
• CPC Class Codes: A23L 33/175 Amino acids
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/4415 Pyridoxine, i.e. Vitamin B6 pyridoxal phosphate A61K31/675
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 31/525 Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 33/06 Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/30 for treating abuse or dependence
• CPC Class Codes: A61P 25/32 Alcohol-abuse
• CPC Class Codes: A61P 29/02 without antiinflammatory effect
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48

Abstract

Compositions are described herein that are nutritional supplements that contain free amino acids. These supplements contain a homogenous mixture of free amino acids, wherein the free-form amino acids comprise L-Lysine, L-Valine, L-Tryptophan, L-Phenylalanine, L-methionine, L-Leucine, L-Threonine, L-Isoleucine, L-Arginine, L-Histidine, L-Tyrosine, L-Carnitine, L-Serine, L-Glutamine, Aspartic Acid, L-Proline, L-Glycine, Taurine, L-Cysteine, Gamma-aminobutyric acid (GABA), L-Alanine, L-Glutamic acid, and wherein the composition comprises at least one B vitamin. These compositions are of use to treat disorders associated with a deficiency at least one amino acid, such as soft tissue injury, insomnia, panic attacks, anxiety disorders, eating disorders, anorexia, depression, chronic pain, emotional distress, chemical dependence, alcoholism, and hypoglycemia.

Claims

1. A nutritional composition comprising a homogenous mixture of free amino acids,

wherein the free-form amino acids comprise L-Lysine, L-Valine, L-Tryptophan or a metabolite thereof, L-Phenylalanine, L-methionine, L-Leucine, L-Threonine, L-Isoleucine, L-Arginine, L-Histidine, L-Tyrosine, L-Carnitine, L-Serine, L-Glutamine, Aspartic Acid, L-Proline, L-Glycine, Taurine, L-Cysteine, Gamma-aminobutyric acid (GABA), L-Alanine, L-Glutamic acid,

and wherein the composition comprises at least one B vitamin.

2. The nutritional composition of claim 1, wherein the at least one B vitamin is vitamin B2, vitamin B3, vitamin B6, folic acid or vitamin B12.

3. The nutritional composition of claim 1, comprising vitamin B2, vitamin B3, vitamin B6, folic acid and vitamin B12.

4. The nutritional composition of claim 3, further comprising magnesium.

5. The nutritional composition of claim 1, comprising 4.5-6.5 percent by weight of L-Tyrosine.

6. The nutritional composition of claim 1, comprising 4-6 percent by weight L-Carnitine.

7. The nutritional composition of claim 1, comprising 2-4 percent by weight GABA.

8. The nutritional composition of claim 1, comprising 5-7 percent by weight L-Tryptophan.

9. The nutritional composition of claim 1, comprising about 0.1 to about 0.5 percent by weight coenzyme vitamin B2.

10. The nutritional composition of claim 1, comprising about 0.1 to about 0.5 percent by weight Vitamin B3.

11. The nutritional composition of claim 1, comprising about 0.1 to about 0.5 percent by weight Vitamin B6.

12. The nutritional composition of claim 1, comprising about 0.0001 to about 0.0003 percent by weight Vitamin B12.

13. The nutritional composition of claim 1, comprising about 0.001 to about 0.003 percent by weight folic acid.

14. The nutritional composition of claim 1, comprising about 2 to about 3 percent by weight an amino acid chelate of magnesium.

15. The nutritional composition of claim 1, comprising the following ingredients as percent by weight:

L-Lysine 5-7% L-Valine 5-7% L-Tryptophan 5-7% L-Phenylalanine 4-6% L-Methionine 4-6% L-Leucine 3-5% L-Threonine 3-5% L-Isoleucine 3-5% L-Arginine 2-4% L-Histidine 2-4% L-Tyrosine 4.5%-6.5% 

 

 

L-Carnitine 4-6% L-Serine 4-6% L-Glutamine 4-6% Aspartic Acid 3-5% L-Proline 2.5-4.5% L-Glycine 2.5-4.5% Taurine 2.5-4.5% L-Cysteine 2.5-4.5% (as N-Acetyl Cysteine) GABA 2-4% L-Alanine 2-4% L-Glutamic acid 2-4%

and a pharmaceutically acceptable carrier.

16. The nutritional composition of claim 15, comprising the following ingredients as percent by weight:

L-Lysine 6-7% L-Valine 6-7% L-Tryptophan 6-7% L-Phenylalanine 5-6% L-Methionine 4-5% L-Leucine 4-5% L-Threonine 4-5% L-Isoleucine 3-4% L-Arginine 3-4% L-Histidine 3-4% L-Tyrosine 5-6% L-Carnitine 4.5-6% 

 

L-Serine 4.5-6% 

 

L-Glutamine 4.5-6% 

 

Aspartic Acid 4-5% L-Proline 3-4% L-Glycine 3-4% Taurine 3-4% L-Cysteine 3-4% GABA 3-4% L-Alanine 3-4% L-Glutamic acid 3-4%

17. The nutritional composition of claim 1, further comprising an effective amount of Coenzyme Vitamin B2, Vitamin B3, Vitamin B6, Vitamin B12, Folic Acid, and Magnesium.

18. The nutritional composition of claim 1, comprising a percent by weight of about:

L-Lysine  

6.25% L-Valine  

6.25% L-Tryptophan  

6.25% L-Phenylalanine 5.625% L-Methionine  

5.0% L-Leucine 4.375% L-Threonine 4.375% L-Isoleucine  

3.75% L-Arginine 3.125% L-Histidine 3.125% L-Tyrosine  

5.5% L-Carnitine  

5.0% L-Serine  

5.0% L-Glutamine  

5.0% Aspartic Acid 4.375% L-Proline  

3.75% L-Glycine  

3.75% Taurine  

3.75% L-Cysteine (as N-Acetyl Cysteine)  

3.75% GABA 3.125% L-Alanine 3.125% L-Glutamic Acid 3.125% Coenzyme Vitamin B2 0.125% Vitamin B3 0.125% Vitamin B6 0.125% Vitamin B12 0.00025% 

Folic Acid 0.00166% 

19. The composition of claim 1, comprising:

L-Lysine 6.21% L-Valine 6.21% L-Tryptophan 6.21% L-Phenylalanine 5.59% L-Methionine  

5.0% L-Leucine 4.35% L-Threonine 4.35% L-Isoleucine 3.73% L-Arginine 3.11% L-Histidine 3.11% L-Tyrosine  

5.5% L-Carnitine  

 

5% L-Serine  

 

5% L-Glutamine  

5.% Aspartic Acid 4.35% L-Proline 3.73% L-Glycine 3.73% Taurine 3.73% L-Cysteine (as N-Acetyl Cysteine) 3.73% GABA 3.11% L-Alanine 3.11% L-Glutamic acid 3.11% Coenzyme Vitamin B2 0.14% Vitamin B3 0.14% Vitamin B6 0.14% Vitamin B12 0.00025% 

 

Folic Acid 0.00186% 

 

20. The composition of claim 18, further comprising about 2 percent by weight magnesium.

21. The nutritional composition of claim 1, formulated for enteral administration.

22. The nutritional composition of claim 21, formulated for oral administration.

23. The nutritional composition of claim 21, wherein the formulated as a solid oral dosage form.

24. The nutritional composition of claim 21, wherein the formulation comprises a pharmaceutically effective carrier.

25. The nutritional composition of claim 21, further comprising a flavoring agent.

26. The nutritional composition of claim 21, further comprising a sweetening agent.

33. A method of ameliorating a condition associated with a relative deficiency of one or more amino acids in a subject, comprising administering to the subject a physiologically effective amount of the composition of claim 1, thereby ameliorating the condition.

34. The method of claim 33, wherein the condition a soft tissue injury.

35. The method of claim 33, wherein the condition is an eating disorder.

36. The method of claim 33, wherein the condition is anorexia.

37. The method of claim 33, wherein the condition is a mood disorder.

38. The method of claim 33, wherein the condition comprises depression, anxiety, a panic disorder, insomnia, fibromyalgia, or a combination thereof.

40. The method of claim 33, wherein the condition is chronic pain.

41. The method of claim 33, wherein the condition is emotional distress.

42. The method of claim 33, wherein the condition is chemically dependence.

43. The method of claim 42, wherein the condition is alcoholism.

44. The method of claim 33, wherein the condition is hypoglycemia.

27. A composition, comprising:

L-lysine hydrochloride 45-55 mg L-Valine 45-55 mg L-Tryptophan 45-55 mg L-Phenylalanine 35-45 mg L-Methionine 35-45 mg L-Leucine 30-40 mg L-Threonine 30-40 mg L-Isoleucine 25-35 mg L-Arginine 20-30 mg L-histidine hydrochloride 20-30 mg L-Tyrosine 40-50 mg L-Carnitine 35-45 mg L-Serine 35-40 mg L-Glutamine 35-40 mg Aspartic Acid 30-40 mg L-Proline 25-35 mg L-Glycine 25-35 mg Taurine 25-35 mg N-Acetyl Cysteine 25-35 mg Gamma aminobutyric acid (GABA) 20-30 mg L-Alanine 20-30 mg L-Glutamic acid 20-30 mg

and a pharmaceutically acceptable carrier.

28. The composition of claim 27, further comprising:

Coenzyme Vitamin B2 0.5-1.5 mg Vitamin B3 0.5-1.5 mg Vitamin B6 0.5-1.5 mg Vitamin 10-30 mcg Folate 100-150 mcg Magnesium, amino acid chelate 10-20 mg

29. The composition of claim 27, comprising

L-lysine hydrochloride 50 mg L-Valine 50 mg L-Tryptophan 50 mg L-Phenylalanine 45 mg L-Methionine 40 mg L-Leucine 35 mg L-Threonine 35 mg L-Isoleucine 30 mg L-Arginine 25 mg L-histidine hydrochloride 25 mg L-Tyrosine 44 mg L-Carnitine 40 mg L-Serine 40 mg L-Glutamine 40 mg Aspartic Acid 35 mg L-Proline 30 mg L-Glycine 30 mg Taurine 30 mg L-Cysteine (as N-Acetyl Cysteine) 30 mg Gamma aminobutyric acid (GABA) 25 mg L-Alanine 25 mg L-Glutamic acid 25 mg

and a pharmaceutically acceptable carrier.

30. The composition of claim 29, further comprising

Vitamin B2 1.1 mg Vitamin B3 1.1 mg Vitamin B6 1.5 mg Vitamin B12 20 mcg Folate 150 mcg Magnesium 16 mg

31. The composition of claim 30, further comprising a lubricant.

32. The composition of claim 31, wherein the lubricant is magnesium stearate.