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Engineered heterodimeric protein domains

  • US 20070287170A1
  • Filed: 03/23/2007
  • Published: 12/13/2007
  • Est. Priority Date: 03/24/2006
  • Status: Active Grant
First Claim
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1. A multidomain protein comprising at least first and second nonidentical engineered domains, each of the first and second engineered domains containing a protein-protein interaction interface comprising amino acid sequence segments derived from two or more naturally occurring homologous parent domains, thereby conferring on said first and second engineered domains assembly specificities distinct from assembly specificities of the parent domains, wherein the first and second engineered domains form heterodimers with one another preferentially over forming homodimers.

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