Pharmaceutical Compositions for Topical Application
First Claim
Patent Images
1. A pharmaceutical composition comprising:
- a) at least one active agent; and
b) a skin penetration enhancer represented by the following Formula I;
wherein;
R represents a linear, saturated or unsaturated, substituted or unsubstituted hydrocarbyl radical; and
X represents a —
(CO)O—
, —
O(CO)—
, C═
O, CONH, O, NHCONH, S, or S═
O radical.
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Abstract
Compounds of Formula I are useful as skin penetration enhancing agents: (I) wherein: R represents a linear, saturated or unsaturated, substituted or unsubstituted hydrocarbyl radical; and X represents a —(CO)O—, —O(CO)—, C═O, CONH, O, NHCONH, S, or S═O radical. Compositions and methods using these compounds are also described.
53 Citations
38 Claims
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1. A pharmaceutical composition comprising:
-
a) at least one active agent; and
b) a skin penetration enhancer represented by the following Formula I;
wherein;
R represents a linear, saturated or unsaturated, substituted or unsubstituted hydrocarbyl radical; and
X represents a —
(CO)O—
, —
O(CO)—
, C═
O, CONH, O, NHCONH, S, or S═
O radical.
-
-
2. A pharmaceutical composition comprising:
-
a) at least one active agent; and
b) a skin penetration enhancer represented by the Formulas IA or IB wherein;
R1 represents a linear or branched, saturated or unsaturated, substituted or unsubstituted hydrocarbyl radical; and
X1 is either an oxygen atom or an NH radical. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method for forming a pharmaceutical or cosmetic composition comprising, mixing:
-
a) from about 1 wt. % to about 10 wt. % of an active agent; and
b) a skin penetration enhancer represented by the Formulas IA or IB wherein;
R1 represents a linear or branched, saturated or unsaturated, substituted or unsubstituted hydrocarbyl radical; and
X1 is either an oxygen atom or an NH radical.
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32. A method of administering an active agent to an animal in need thereof comprising topically applying to said animal a pharmaceutical composition comprising:
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a) an active agent; and
b) a skin penetration enhancer represented by the Formulas IA or IB wherein;
R1 represents a linear or branched, saturated or unsaturated, substituted or unsubstituted hydrocarbyl radical; and
X1 is either an oxygen atom or an NH radical. - View Dependent Claims (33, 34, 35, 36, 37, 38)
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Specification