Certain substituted quinolones, compositions, and uses thereof

US 20070287706A1
Filed: 05/10/2007
Published: 12/13/2007
Est. Priority Date: 05/18/2006
Status: Abandoned Application

First Claim

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1. At least one chemical entity chosen from compounds of Formula I and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof, wherein m is chosen from 0, 1, 2, 3, and 4;

for each occurrence, R¹is independently chosen from halo, cyano, hydroxy, carboxy, nitro, alkoxy, substituted alkoxy, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, sulfanyl, substituted sulfanyl, sulfinyl, substituted sulfinyl, amino, substituted amino, aminocarbonyl, substituted aminocarbonyl, sulfonyl, substituted sulfonyl, acyl, and substituted acyl;

or wherein m is 2 or 3, two of R¹may form an alkylene dioxy;

R²is hydrogen;

n is chosen from 0, 1, and 2;

for each occurrence, R³and R⁴are independently chosen from hydrogen, optionally substituted alkoxycarbonyl, aminocarbonyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;

R⁵is chosen from hydrogen, acyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;

R⁶is chosen from —

C(O)—

R¹, —

C(O)O—

R¹², —

C(S)—

NR⁷R⁸, —

C(O)—

NR⁷R⁸and —

S(O)₂R⁹;

R⁷is chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;

R⁸is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocycloalkyl;

or R⁷and R⁸, taken together with the nitrogen to which they are attached, form an optionally substituted heterocycloalkyl ring;

R⁹is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocycloalkyl;

R¹⁰is chosen from hydrogen, halo, cyano, hydroxy, carboxy, nitro, alkoxy, substituted alkoxy, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, sulfanyl, substituted sulfanyl, sulfinyl, substituted sulfinyl, amino, substituted amino, aminocarbonyl, substituted aminocarbonyl, sulfonyl, substituted sulfonyl, acyl, and substituted acyl;

R¹¹is chosen from optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; and

R¹²is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted heterocycloalkyl, provided that if n is 0, R¹⁰is hydrogen, R⁵is hydrogen, R⁶is —

S(O)₂R⁹, then R⁹is not chosen from methyl, trifluoromethyl, phenyl, and thienyl;

if n is 0, R¹⁰is hydrogen, m is 1, R¹is lower alkyl, R⁶is —

C(O)R¹¹, R¹¹is chosen from methyl, benzyl, and methyl substituted with a group chosen from optionally substituted amino and optionally substituted heterocycloalkyl, then R⁵is not hydrogen;

if n is 1, R⁶is —

C(S)—

NR⁷R⁸, R³is hydrogen, R⁴is hydrogen, R⁷is hydrogen, and R⁸is chosen from naphthyl, 3-methoxyphenyl, 4-methoxyphenyl, and 3,4-dimethoxyphenyl, then R⁵is not —

(CH₂)_rN—

(R¹³)₂where R¹³is chosen from fluorophenyl and trifluoromethylphenyl and r is chosen from 0, 1, 2, and 3;

if n is 1, R⁶is —

C(S)—

NR⁷R⁸, R³is hydrogen, R⁴is hydrogen, R⁷is hydrogen, and R⁸is phenethyl, then R⁵is not chosen from hydrogen, 1-isopropylpiperidin-4-yl, and 1-(pentan-3-yl)piperidin-4-yl;

if n is 1, R³and R⁴are hydrogen, R¹⁰is hydrogen, m is 1, R¹is chosen from halo, phenyl and substituted phenyl, R⁵is chosen from —

C(O)—

NR⁷R⁸and —

C(S)—

NR⁷R⁸, R⁷is hydrogen, R⁸is chosen from substituted phenyl and naphthyl, then R⁵is not -L-NR¹⁴R¹⁵wherein L is chosen from phenylene, -methylcyclohexylmethyl, lower alkylene, and a covalent bond and R¹⁴and R¹⁵are independently chosen from substituted phenyl wherein the substituents on the phenyl are independently chosen from halo and trifluoromethyl;

if n is 1, R³and R⁴are hydrogen, R¹⁰is hydrogen, m is 0, R⁶is —

C(S)—

NR⁷R⁸, R⁷hydrogen, R⁸is methoxyphenyl, then R⁵is not -L′

-NR¹⁴R¹⁵wherein L¹is chosen from lower alkylene and a covalent bond and R¹⁴and R¹⁵are independently chosen from substituted phenyl wherein the substituents on the phenyl are independently chosen from halo and trifluoromethyl;

if n is 1, R³and R⁴are hydrogen, R¹⁰is hydrogen, m is 2, each occurrence of R¹is independently chosen from halo and methyl, R⁶is —

C(S)—

NR⁷R⁸, R⁷is hydrogen, R⁸is chosen from phenethyl, naphthyl and methoxyphenyl, then R⁵is not -L²-NR¹⁴R¹⁵wherein L²is chosen from lower alkylene and a covalent bond and R¹⁴and R¹⁵are independently chosen from lower alkyl and substituted phenyl wherein the substituents on the phenyl are independently chosen from halo and trifluoromethyl or wherein R¹⁴and R ⁵, together with the nitrogen to which they are bound, form a piperidinyl ring;

if n is 1, R³and R⁴are hydrogen, R¹⁰is hydrogen, m is 0, R⁶is —

C(S)—

NR⁷R⁸, R⁷is hydrogen, R⁸is chosen from phenethyl and fluorobenzyl, then R⁵is not optionally substituted heterocycloalkyl;

and the compound of Formula I is not N-(2-bromoethyl)-4-methyl-N-(2-oxo-1,2-dihydroquinolin-3-yl)benzenesulfonamide.

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Abstract

Certain quinolone-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions comprising compounds exhibiting ATP-utilizing enzyme inhibitory activity, are disclosed.

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56 Claims

1. At least one chemical entity chosen from compounds of Formula I and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof, wherein m is chosen from 0, 1, 2, 3, and 4;
- for each occurrence, R¹is independently chosen from halo, cyano, hydroxy, carboxy, nitro, alkoxy, substituted alkoxy, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, sulfanyl, substituted sulfanyl, sulfinyl, substituted sulfinyl, amino, substituted amino, aminocarbonyl, substituted aminocarbonyl, sulfonyl, substituted sulfonyl, acyl, and substituted acyl;
  
  or wherein m is 2 or 3, two of R¹may form an alkylene dioxy;
  
  R²is hydrogen;
  
  n is chosen from 0, 1, and 2;
  
  for each occurrence, R³and R⁴are independently chosen from hydrogen, optionally substituted alkoxycarbonyl, aminocarbonyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
  
  R⁵is chosen from hydrogen, acyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
  
  R⁶is chosen from —
  
  C(O)—
  
  R¹, —
  
  C(O)O—
  
  R¹², —
  
  C(S)—
  
  NR⁷R⁸, —
  
  C(O)—
  
  NR⁷R⁸and —
  
  S(O)₂R⁹;
  
  R⁷is chosen from hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
  
  R⁸is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocycloalkyl;
  
  or R⁷and R⁸, taken together with the nitrogen to which they are attached, form an optionally substituted heterocycloalkyl ring;
  
  R⁹is chosen from optionally substituted alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, and optionally substituted heterocycloalkyl;
  
  R¹⁰is chosen from hydrogen, halo, cyano, hydroxy, carboxy, nitro, alkoxy, substituted alkoxy, alkyl, substituted alkyl, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, sulfanyl, substituted sulfanyl, sulfinyl, substituted sulfinyl, amino, substituted amino, aminocarbonyl, substituted aminocarbonyl, sulfonyl, substituted sulfonyl, acyl, and substituted acyl;
  
  R¹¹is chosen from optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl; and
  
  R¹²is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, and optionally substituted heterocycloalkyl, provided that if n is 0, R¹⁰is hydrogen, R⁵is hydrogen, R⁶is —
  
  S(O)₂R⁹, then R⁹is not chosen from methyl, trifluoromethyl, phenyl, and thienyl;
  
  if n is 0, R¹⁰is hydrogen, m is 1, R¹is lower alkyl, R⁶is —
  
  C(O)R¹¹, R¹¹is chosen from methyl, benzyl, and methyl substituted with a group chosen from optionally substituted amino and optionally substituted heterocycloalkyl, then R⁵is not hydrogen;
  
  if n is 1, R⁶is —
  
  C(S)—
  
  NR⁷R⁸, R³is hydrogen, R⁴is hydrogen, R⁷is hydrogen, and R⁸is chosen from naphthyl, 3-methoxyphenyl, 4-methoxyphenyl, and 3,4-dimethoxyphenyl, then R⁵is not —
  
  (CH₂)_rN—
  
  (R¹³)₂where R¹³is chosen from fluorophenyl and trifluoromethylphenyl and r is chosen from 0, 1, 2, and 3;
  
  if n is 1, R⁶is —
  
  C(S)—
  
  NR⁷R⁸, R³is hydrogen, R⁴is hydrogen, R⁷is hydrogen, and R⁸is phenethyl, then R⁵is not chosen from hydrogen, 1-isopropylpiperidin-4-yl, and 1-(pentan-3-yl)piperidin-4-yl;
  
  if n is 1, R³and R⁴are hydrogen, R¹⁰is hydrogen, m is 1, R¹is chosen from halo, phenyl and substituted phenyl, R⁵is chosen from —
  
  C(O)—
  
  NR⁷R⁸and —
  
  C(S)—
  
  NR⁷R⁸, R⁷is hydrogen, R⁸is chosen from substituted phenyl and naphthyl, then R⁵is not -L-NR¹⁴R¹⁵wherein L is chosen from phenylene, -methylcyclohexylmethyl, lower alkylene, and a covalent bond and R¹⁴and R¹⁵are independently chosen from substituted phenyl wherein the substituents on the phenyl are independently chosen from halo and trifluoromethyl;
  
  if n is 1, R³and R⁴are hydrogen, R¹⁰is hydrogen, m is 0, R⁶is —
  
  C(S)—
  
  NR⁷R⁸, R⁷hydrogen, R⁸is methoxyphenyl, then R⁵is not -L′
  
  -NR¹⁴R¹⁵wherein L¹is chosen from lower alkylene and a covalent bond and R¹⁴and R¹⁵are independently chosen from substituted phenyl wherein the substituents on the phenyl are independently chosen from halo and trifluoromethyl;
  
  if n is 1, R³and R⁴are hydrogen, R¹⁰is hydrogen, m is 2, each occurrence of R¹is independently chosen from halo and methyl, R⁶is —
  
  C(S)—
  
  NR⁷R⁸, R⁷is hydrogen, R⁸is chosen from phenethyl, naphthyl and methoxyphenyl, then R⁵is not -L²-NR¹⁴R¹⁵wherein L²is chosen from lower alkylene and a covalent bond and R¹⁴and R¹⁵are independently chosen from lower alkyl and substituted phenyl wherein the substituents on the phenyl are independently chosen from halo and trifluoromethyl or wherein R¹⁴and R ⁵, together with the nitrogen to which they are bound, form a piperidinyl ring;
  
  if n is 1, R³and R⁴are hydrogen, R¹⁰is hydrogen, m is 0, R⁶is —
  
  C(S)—
  
  NR⁷R⁸, R⁷is hydrogen, R⁸is chosen from phenethyl and fluorobenzyl, then R⁵is not optionally substituted heterocycloalkyl;
  
  and the compound of Formula I is not N-(2-bromoethyl)-4-methyl-N-(2-oxo-1,2-dihydroquinolin-3-yl)benzenesulfonamide.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
- - 2. At least one chemical entity of claim 1 wherein m is 1.
  - 3. At least one chemical entity of claim 1 wherein m is 2.
  - 4. At least one chemical entity of claim 1 wherein for each occurrence, R¹is independently chosen from halo, hydroxy, carboxy, nitro, lower alkoxy, substituted lower alkoxy, lower alkyl, and substituted lower alkyl.
  - 5. At least one chemical entity of claim 1 wherein m is 0.
  - 6. At least one chemical entity of claim 1 wherein n is 1.
  - 7. At least one chemical entity of claim 1 wherein R³and R⁴are independently chosen from hydrogen and optionally substituted alkyl.
  - 8. At least one chemical entity of claim 7 wherein R³and R⁴are independently chosen from hydrogen and optionally substituted lower alkyl.
  - 9. At least one chemical entity of claim 8 wherein R³and R⁴are hydrogen.
  - 10. At least one chemical entity of claim 1 wherein R⁵is chosen from acyl, optionally substituted phenyl, optionally substituted alkyl and optionally substituted cycloalkyl.
  - 11. At least one chemical entity of claim 10 wherein R⁵is chosen from optionally substituted lower alkyl and optionally substituted cycloalkyl.
  - 12. At least one chemical entity of claim 11 wherein R⁵is chosen from optionally substituted cyclohexyl, optionally substituted cyclopentyl, lower alkyl, and lower alkyl substituted with a group chosen from optionally substituted heterocycloalkyl, hydroxyl, optionally substituted amino, optionally substituted aryl, and optionally substituted heteroaryl.
  - 13. At least one chemical entity of claim 12 wherein R⁵is chosen from optionally substituted lower alkyl and optionally substituted cyclopentyl.
  - 14. At least one chemical entity of claim 13 wherein R⁵is chosen from optionally substituted cyclopentyl.
  - 15. At least one chemical entity of claim 1 wherein R⁶is chosen from —
    - C(S)—
      
      NR⁷R⁸and —
      
      C(O)—
      
      NR⁷R⁸.
  - 16. At least one chemical entity of claim 15 wherein R⁷is chosen from hydrogen and optionally substituted alkyl.
  - 17. At least one chemical entity of claim 16 wherein R⁷is chosen from hydrogen and optionally substituted lower alkyl.
  - 18. At least one chemical entity of claim 17 wherein R⁷is chosen from hydrogen and lower alkyl.
  - 19. At least one chemical entity of claim 18 wherein R⁷is hydrogen.
  - 20. At least one chemical entity of claim 1 wherein R⁸is chosen from optionally substituted alkyl and optionally substituted aryl.
  - 21. At least one chemical entity of claim 20 wherein R⁸is chosen from optionally substituted lower alkyl and optionally substituted phenyl.
  - 22. At least one chemical entity of claim 21 wherein R⁸is chosen from lower alkyl, lower alkyl substituted with a group chosen from optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted phenyl, optionally substituted amino, and optionally substituted lower alkoxy, phenyl, and phenyl substituted with one or two groups chosen from halo, lower alkyl, lower alkoxy, and hydroxy.
  - 23. At least one chemical entity of claim 22 wherein R⁸is chosen from lower alkyl, lower alkyl substituted with a group chosen from optionally substituted furan-2yl, optionally substituted morpholinyl, optionally substituted tetrahydrofuran-2-yl, phenyl, alkylamino, dialkylamino, and lower alkoxy, phenyl, and phenyl substituted with one or two groups chosen from halo, lower alkyl, lower alkoxy, and hydroxy.
  - 24. At least one chemical entity claim 1 wherein R⁶is —
    - S(O)₂R⁹.
  - 25. At least one chemical entity of claim 24 wherein R⁹is chosen from optionally substituted aryl and optionally substituted heteroaryl.
  - 26. At least one chemical entity of claim 25 wherein R⁹is chosen from aryl and aryl substituted with one or two groups chosen from alkoxycarbonyl, carbonyl, lower alkoxy, lower alkyl, hydroxy, and halo.
  - 27. At least one chemical entity of claim 26 wherein R⁹is chosen from 3,4-dihydro-2H-benzo[b][1,4]oxazine;
    - 3,4-dihydro-2H-benzo[b][1,4]oxazine substituted with one or two groups chosen from alkoxycarbonyl, carbonyl, lower alkoxy, lower alkyl, hydroxy, and halo;
      
      phenyl; and
      
      phenyl substituted with one or two groups chosen from alkoxycarbonyl, carbonyl, lower alkoxy, lower alkyl, hydroxy, and halo.
  - 28. At least one chemical entity of claim 1 wherein R⁶is —
    - C(O)—
      
      R¹¹.
  - 29. At least one chemical entity of claim 28 wherein R¹¹is optionally substituted lower alkyl.
  - 30. At least one chemical entity of claim 28 wherein R¹¹is lower alkyl.
  - 31. At least one chemical entity of claim 1 wherein R⁶is —
    - C(O)O—
      
      R¹².
  - 32. At least one chemical entity of claim 31 wherein R¹²is optionally substituted lower alkyl.
  - 33. At least one chemical entity of claim 32 wherein R¹²is lower alkyl.
  - 34. At least one chemical entity of claim 1 wherein the at least one chemical entity is an inhibitor of at least one ATP-utilizing enzyme.
  - 35. At least one chemical entity of a claim 34 wherein the at least one ATP-utilizing enzyme is chosen from a human protein kinase.
  - 36. At least one chemical entity of claim 35 wherein the human protein kinase is an Aurora kinase.
  - 37. A pharmaceutical composition comprising at least one pharmaceutically acceptable vehicle, and a therapeutically effective amount of at least one chemical entity of claim 1.
  - 38. The pharmaceutical composition of claim 37, wherein the at least one chemical entity is present in an amount effective for the treatment in a patient of at least one disease chosen from transplant rejection, osteoarthritis, rheumatoid arthritis, multiple sclerosis, diabetes, diabetic retinopathy, asthma, inflammatory bowel disease, renal disease cachexia, septic shock, lupus, diabetes mellitus, myasthenia gravis, psoriasis, dermatitis, eczema, seborrhea, Alzheimer'"'"'s disease, Parkinson'"'"'s disease, stem cell protection during chemotherapy, ex vivo selection or ex vivo purging for autologous or allogeneic bone marrow transplantation, leukemia, cancer, ocular disease, corneal disease, glaucoma, bacterial infections, viral infections, fungal infections, heart disease, stroke, obesity, endometriosis, atherosclerosis, vein graft stenosis, peri-anastomatic prosthetic graft stenosis, prostate hyperplasia, chronic obstructive pulmonary disease, inhibition of neurological damage due to tissue repair, scar tissue formation, wound healing, pulmonary disease, neoplasm, and macular degeneration.
  - 39. The pharmaceutical composition of claim 38, wherein cancer is chosen from at least one of glioblastoma, ovarian cancer, breast cancer, endometrial carcinoma, hepatocellular carcinoma, melanoma, colorectal cancer, colon cancer, digestive tract, lung cancer, renal-cell carcinoma, thyroid, lymphoid, prostate cancer and pancreatic cancer, etc. advanced tumors, hairy cell leukemia, melanoma, chronic myelygenous leukemia, advanced bead and neck. metastatic renal cell, non-Hodgkin'"'"'s lymphoma, metastatic breast, breast adenocarcinoma. advanced melanoma. pancreatic, gastric, non-small cell lung, small cell lung, renal cell carcinoma. various solid tumors, multiple myeloma, metastatic prostate, malignant glioma. renal cancer, lymphoma. refractory metastatic disease, refractory multiple myeloma, cervical cancer, Kaposi'"'"'s sarcoma, recurrent anaplastic glioma, and metastatic colon cancer.
  - 40. The pharmaceutical composition of claim 39, wherein cancer is chosen from at least one of breast cancer, lung cancer, colorectal cancer, ovary cancer, prostate cancer, renal cancer, squamous cell cancer, glioblastoma, melanoma, pancreatic cancer, and Kaposi'"'"'s sarcoma.
  - 41. The pharmaceutical composition of claim 38 further comprising at least one additional therapeutic agent appropriate for effecting combination therapy.
  - 42. A method of treating at least one disease in a patient in need of such treatment comprising administering to the patient a therapeutically effective amount of at least one chemical entity of claim 1 or at least one chemical entity chosen from 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(furan-2-ylmethyl)-1-(3-morpholinopropyl)thiourea;
    - 1-(3-hydroxypropyl)-1-((7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-morpholinopropyl)thiourea;
      
      1-(2-(diethylamino)ethyl)-3-(4-fluorophenyl)-1-((7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-(2-hydroxyethyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-phenethylthiourea;
      
      1-(3-(dimethylamino)propyl)-3-(4-fluorophenyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(3-hydroxypropyl)-3-(3-morpholinopropyl)thiourea;
      
      1-(2-hydroxyethyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(1-phenylethyl)thiourea;
      
      1-(2-hydroxyethyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-methoxyphenyl)thiourea;
      
      1-(2-hydroxyethyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-((tetrahydrofuran-2-yl)methyl)thiourea;
      
      3-ethyl-1-(3-hydroxypropyl)-1-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      3-(3-chlorophenyl)-1-(3-(diethylamino)propyl)-1-((7-oxo-2,3,6,7-tetrahydro-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl)thiourea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-(dimethylamino)propyl)thiourea;
      
      3-(3-chlorophenyl)-1-(2-hydroxyethyl)-1-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((7-chloro-6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-(dimethylamino)propyl)-1-(4-fluorobenzyl)thiourea;
      
      3-benzyl-1-(2-hydroxyethyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((7-chloro-6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-fluorobenzyl)-3-(2-methoxyethyl)thiourea;
      
      1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-fluorobenzyl)-3-methylthiourea;
      
      1-(4-fluorobenzyl)-1-((7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-methoxypropyl)thiourea;
      
      3-ethyl-1-(4-fluorobenzyl)-1-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-fluorobenzyl)-3-(2-methoxyethyl)thiourea;
      
      1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-methoxybenzyl)-3-(2-methoxyethyl)thiourea;
      
      1-(furan-2-ylmethyl)-1-((6-oxo-5,6-dihydro-[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl)-3-phenylthiourea;
      
      1-benzyl-1-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-phenylthiourea;
      
      3-(furan-2-ylmethyl)-1-(4-methoxybenzyl)-1-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-(benzo[d][1,3]dioxoi-5-ylmethyl)-1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(2-methoxyethyl)thiourea;
      
      1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-methoxybenzyl)-3-(3-morpholinopropyl)thiourea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-(diethylamino)propyl)-1-((6-ethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-(dimethylamino)ethyl)-3-(4-methoxyphenyl)thiourea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-(diethylamino)propyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((7-chloro-6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-fluorobenzyl)-3-(3-morpholinopropyl)thiourea;
      
      3-(2-methoxyethyl )-1-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(3-morpholinopropyl)thiourea;
      
      1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(3-morpholinopropyl)-3-(1-phenylethyl)thiourea;
      
      3-(3-(diethylamino)propyl)-1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(3-hydroxypropyl)thiourea;
      
      3-benzyl-1-((6-ethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)thiourea;
      
      1-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-fluorophenyl)-1-(2-hydroxyethyl)thiourea;
      
      ethyl 4-(N-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-hydroxypropyl)sulfamoyl)benzoate;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-hydroxyethyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methoxy-N-((tetrahydrofuran-2-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-4-methoxy-N-((7-oxo-2,3,6,7-tetrahydro-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl)benzenesulfonamide;
      
      4-chloro-N-(3-hydroxypropyl)-N-((7-oxo-2,3,6,7-tetrahydro-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-5-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide;
      
      N-(3-hydroxypropyl )-N-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide;
      
      N-(3-hydroxypropyl)-4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide;
      
      N-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide;
      
      4-tert-butyl-N-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-hydroxyethyl)benzenesulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-hydroxypropyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide;
      
      4-chloro-N-(3-hydroxypropyl)-N-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-hydroxyethyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide;
      
      4-acetyl-N-(2-hydroxyethyl)-N-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      methyl 4-(N-cyclohexyl-N-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)sulfamoyl)benzoate;
      
      N-(4-fluorobenzyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-fluoro-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(4-methoxybenzyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-4-methyl-N-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-N-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide;
      
      3-(((benzo[d][1,3]dioxol-5-ylmethyl)(2-hydroxyethyl)amino)methyl)-6,8-dimethylquinolin-2(1H)-one;
      
      3-(((benzo[d][1,3]dioxol-5-ylmethyl)(benzyl)amino)methyl)-6,8-dimethylquinolin-2(1H)-one;
      
      3-(((benzo[d][1,3]dioxol-5-ylmethyl)(cyclohexylmethyl)amino)methyl)-6,8-dimethylquinolin-2(1H)-one;
      
      1-acetyl-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)piperidine-4-carboxamide;
      
      methyl 5-((benzo[d][1,3]dioxol-5-ylmethyl)((6, 8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)amino)-5-oxopentanoate;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-methoxypropanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(diethylamino)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)pentanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-phenylpropanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)cyclopentanecarboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(diethylamino)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)propanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-(dimethylamino)butanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2-phenylacetamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2-(dimethylamino)acetamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)propionamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-methylpiperidine-4-carboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)quinoxaline-6-carboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)furan-2-carboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)cyclohexanecarboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)butyramide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-methyl-1H-pyrrole-2-carboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)pentanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)cyclopropanecarboxamide;
      
      4-acetamido-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)isoxazole-5-carboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)isobutyramide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-5-methyl-1H-pyrazole-3-carboxamide;
      
      N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-(2-oxopyrrolidin-1-yl)benzyl)propionamide;
      
      N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-(dimethylamino)benzyl)propionamide;
      
      N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methoxyphenethyl)propionamide;
      
      N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methoxybenzyl)propionamide;
      
      N-(2,3-dihydro-1H-inden-1-yl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)propionamide;
      
      N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)propionamide;
      
      N-((6, 8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(pyridin-4-ylmethyl)propionamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)propionamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((2-oxo-1,2-dihydroquinolin-3-yl)methyl)propionamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-(quinolin-3-ylmethyl)propionamide;
      
      2-fluoroethyl benzo[d][1,3]dioxol-5-ylmethyl((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)carbamate;
      
      ethyl benzo[d][1,3]dioxol-5-ylmethyl((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)carbamate;
      
      N-(3-hydroxypropyl)-3,4-dimethoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      4-fluoro-N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      4-chloro-N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-hydroxypropyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-3-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      3-acetyl-N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide;
      
      3-fluoro-N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl )-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-(1H-pyrazol-1-yl)benzenesulfonamide;
      
      4-acetyl-N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-3,5-dimethyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl )-2,5-dimethoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)(phenyl)methanesulfonamide;
      
      4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((tetrahydrofuran-2-yl)methyl)benzenesulfonamide;
      
      4-methoxy-N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-morpholinopropyl)benzenesulfonamide;
      
      N-butyl-4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-(2-oxopyrrolidin-1-yl)propyl)benzenesulfonamide;
      
      4-methoxy-N-(3-(methyl(phenyl)amino)propyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-(diethylamino)propyl)-4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-(4-methylpiperazin-1-yl)propyl)benzenesulfonamide;
      
      N-(3-methoxypropyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl )methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(2-methoxyethyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(pyridin-3-ylmethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-(4-methylpiperazin-1-yl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-benzyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-propyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(furan-2-ylmethyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(2-(4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamido)ethyl)acetamide;
      
      N-(2-hydroxyethyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(pyridin-4-ylmethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(2-(diethylamino)ethyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-ethyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl )-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-(4-methylpiperazin-1-yl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-6-phenoxypyridine-3-sulfonamide;
      
      N-(5-(N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)sulfamoyl)-4-methylthiazol-2-yl)acetamide;
      
      N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiophene-2-sulfonamide;
      
      4-(3,3-dimethylureido)-N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-methoxypropyl)-1,3,5-trimethyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1H-pyrazole-4-sulfonamide;
      
      N-(4-(N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)sulfamoyl)phenyl)acetamide;
      
      N-(4-(N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)sulfamoyl)phenyl)morpholine-4-carboxamide;
      
      N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-(methylsulfonyl)benzenesulfonamide;
      
      N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-6-morpholinopyridine-3-sulfonamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)ethanesulfonamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methoxybenzenesulfonamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-methoxypropyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-methoxypropyl )-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-methoxypropyl)-4-methyl-N-((2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((2-chloroquinolin-3-yl)methyl)-N-(3-methoxypropyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-methoxypropyl)-4-methyl-N-(quinolin-3-ylmethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      ethyl 4-(3-(benzo[d][1,3]dioxol-5-ylmethyl)-3-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)ureido)butanoate;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-morpholinopropyl)thiourea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-butyl-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(furan-2-ylmethyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-methoxyphenethyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(2-(thiophen-2-yl)ethyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-(diethylamino)propyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-methoxypropyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-benzyl-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-methoxybenzyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-hydroxypropyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-chlorophenyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-propylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-methoxyphenyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyclopropyl-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-isopropylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-phenylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-phenylurea;
      
      1-(3,4-dimethoxybenzyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethylurea;
      
      1-benzyl-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethylurea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethyl-1-(pyridin-4-ylmethyl)urea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethyl-1-(4-methoxybenzyl)urea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethyl-1-(pyridin-3-ylmethyl)urea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethyl-1-(4-methoxyphenethyl)urea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethyl-1-(3-methyl-1H-pyrazol-5-yl)urea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(3-(dimethylamino)benzyl)-3-ethylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-ethyl-1-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-ethyl-1-((2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-ethyl-1-(quinolin-3-ylmethyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-ethyl-1-((2-methoxypyridin-3-yl)methyl)urea;
      
      N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-4-methyl-N-((2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-4-methyl-N-((1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(1-methylpiperidin-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(4-hydroxybutyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(tetrahydro-2H-pyran-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(Exo-bicyclo[2.2.1]heptan-2-yl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-(4-methylpiperazin-1-yl)propyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-butyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclopentyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isobutyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(2-cyanoethyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(4-(dimethylamino)butyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-N-((2-methoxyquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(trans-4-hydroxycyclohexyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      2-(4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamido)acetic acid;
      
      N-cyclopropyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-(dimethylamino)-2,2-dimethylpropyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(tetrahydro-1h-3A6-thiophene-1,1-dione)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-(4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamido)butanoic acid, 4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((1-methylpiperidin-4-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclohexyl-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-butyl-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclopentyl-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((trans)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((trans)-4-hydroxycyclohexyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((1R,2S)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl )methyl)-N-((1S,2S)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((cis)-2-hydroxycyclohexyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((trans)-2-hydroxycyclohexyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((1R,2R)-2-hydroxycyclopentyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonamide;
      
      N-((trans)-2-hydroxycyclopentyl)-N-((7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((trans)-4-aminocyclohexyl)-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      tert-butyl (trans)-4-(N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamido)cyclohexylcarbamate;
      
      N-isopropyl-N-((7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-N-((8-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      tert-butyl 3-(N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamido)cyclohexylcarbamate;
      
      N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ylsulfonyl)pentanamide;
      
      N-((7,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((trans)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((trans)-2-hydroxycyclopentyl)-N-((8-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-aminocyclohexyl)-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((1R,2R)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonamide;
      
      N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ylsulfonyl)cyclopentanecarboxamide;
      
      N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ylsulfonyl)acetamide;
      
      N-((1S,2S)-2-hydroxycyclopentyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonamide;
      
      2-hydroxy-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ylsulfonyl)pentanamide;
      
      N-((8-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((trans)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((5,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((8-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-4-methyl-N-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((trans)-2-hydroxycyclopentyl)-4-methyl-N-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-4-methyl-N-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(trans-2-hydroxycyclopentyl)-4-methyl-N-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((5,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(trans-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclobutyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclobutyl-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(cis-2-hydroxycyclopentyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(cis-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(cis-4-hydroxycyclohexyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclohexyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(trans-2-hydroxycyclohexyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(cis-2-hydroxycyclohexyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((8-ethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide; and
      
      N-isopropyl-N-((8-isopropyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide, and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof.
  - 43. The method of claim 42 wherein the at least one chemical entity is present in an amount effective for the treatment in a patient of at least one disease chosen from transplant rejection, osteoarthritis, rheumatoid arthritis, multiple sclerosis, diabetes, diabetic retinopathy, asthma, inflammatory bowel disease, renal disease cachexia, septic shock, lupus, diabetes mellitus, myasthenia gravis, psoriasis, dermatitis, eczema, seborrhea, Alzheimer'"'"'s disease, Parkinson'"'"'s disease, stem cell protection during chemotherapy, ex vivo selection or ex vivo purging for autologous or allogeneic bone marrow transplantation, leukemia, cancer, ocular disease, corneal disease, glaucoma, bacterial infections, viral infections, fungal infections, heart disease, stroke, obesity, endometriosis, atherosclerosis, vein graft stenosis, peri-anastomatic prosthetic graft stenosis, prostate hyperplasia, chronic obstructive pulmonary disease, inhibition of neurological damage due to tissue repair, scar tissue formation, wound healing, pulmonary disease, neoplasm, and macular degeneration.
  - 44. The method of claim 43 wherein cancer is chosen from at least one of glioblastoma, ovarian cancer, breast cancer, endometrial carcinoma, hepatocellular carcinoma, melanoma, colorectal cancer, colon cancer, digestive tract, lung cancer, renal-cell carcinoma, thyroid, lymphoid, prostate cancer, pancreatic cancer, advanced tumors, hairy cell leukemia, melanoma, chronic myelygenous leukemia, advanced head and neck, squamous cell cancer, metastatic renal cell, non-Hodgkin'"'"'s lymphoma, metastatic breast, breast adenocarcinoma, advanced melanoma, pancreatic, gastric, non-small cell lung, small cell lung, renal cell carcinoma, various solid tumors, multiple myeloma, metastatic prostate, malignant glioma, renal cancer, lymphoma, refractory metastatic disease, refractory multiple myeloma, cervical cancer, Kaposi'"'"'s sarcoma, recurrent anaplastic glioma, and metastatic colon cancer.
  - 45. The method of claim 44, wherein cancer is chosen from at least one of breast cancer, lung cancer, colorectal cancer, ovarian cancer, prostate cancer, renal cancer, squamous cell cancer, glioblastoma, melanoma, pancreatic cancer, and Kaposi'"'"'s sarcoma.
  - 46. The method of claim 45, wherein cancer is chosen from at least one of:
    - Cardiac;
      
      sarcoma (angiosarcoma, fibrosarcoma, rhabdomyosarcoma, liposarcoma), myxoma, rhabdomyoma, fibroma, lipoma, teratoma;
      
      Lung;
      
      bronchogenic carcinoma (squamous cell, undifferentiated small cell, undifferentiated large cell, adenocarcinoma), alveolar (bronchiolar) carcinoma, bronchial adenoma, sarcoma, lymphoma, chondromatous hamartoma, mesothelioma;
      
      Gastrointestinal;
      
      esophagus (squamous, cell carcinoma, adenocarcinoma, leiomyosarcoma, lymphoma) stomach (carcinoma, lymphoma, leiomyosarcoma), pancreas (ductal adenocarcinoma, insulinoma, glucagonoma, gastrinoma, carcinoid tumors, Karposi'"'"'s sarcoma, leiomyoma, hemangioma, lipoma, neurofibroma, fibroma), large bowel (adenocarcinomas, tubular adenoma, villous adenoma, hamartoma, leiomyoma);
      
      Genitourinary tract;
      
      kidney (adenocarcinoma, Wilm'"'"'s tumor[nephroblastoma], lymphoma, leukemia), bladder and uretha (squamous cell carcinoma, transitional cell carcinoma, adenocarcinoma), prostate (adenocarcinoma, sarcoma), testis (seminoma, teratoma, embroyonal carcinoma, teratocarcinoma, choriocarcinoma, sarcoma, interstitial cell carcinoma, fibroma, fibroadenoma, adenomatoid tumors, lipoma);
      
      Liver;
      
      hepatoma (hepatocellular carcinoma), cholangiocarcinoma, hepatoblastoma, angiosarcoma, hepatocellular adenoma, hemangioma;
      
      Bone;
      
      osteogenic sarcoma (osteosarcoma), fibrosarcoma, malignant fibrous histocytoma, chondrosarcoma, Ewing'"'"'s sarcoma, malignant lymphoma (reticulum cell sarcoma), multiple myeloma, malignant giant cell tumor chordoma, osteochronforma (osteocartilaginous exostoses), benign chrodroma, chondroblastoma, chondromyxofibroma, osteoid osteoma and giant cell tumors;
      
      Nervous system;
      
      skull (osteoma, hemangioma, granuloma, xanthoma, osteitis deformans, meninges (meningioma, meningiosarcoma, gliomatosis), brain (astrocytoma, medulloblastoma, glioma, ependymoma, germinoma [pinealoma], glioblastoma multiform, oligodendroglioma, schwannoma, retinoblastoma, congenitial tumors), spinal cord, neurofibroma, meningioma, glioma, sarcoma);
      
      Gynecological;
      
      uterus (endometrial carcinoma), cervix (cervical carcinoma, pre-tumor cervical dsplasia), ovaries (ovarian carcinoma [serous cystadenocarcinoma, mucinous cystadenocarcinoma], granulose-thecal cell tumors, Sertoli-Leydig cell tumors, dysgerminoma, malignant teratoma), vulva (squamous cell carcinoma, intraepithelial carcinoma, adenocarcinoma, firosarcoma, melanoma) vagina (clear cell carcinoma, squamous cell carcinoma, botryoid sarcoma (embryonal rhabdomyosarcoma), fallopian tubes carcinoma);
      
      Hematologic;
      
      blood (myeloid leukemia (acute and chronic], acute lymphoblastic leukemia, chronic lymphocytic leukemia, myeloproliferative diseases, multiple myeloma, myelodysplastic syndrome), Hodgkin'"'"'s disease, non-Hodgkins'"'"'s lymphoma [malignant lymphoma];
      
      Skin;
      
      malignant melanoma, basel cell carcinoma, squamous cell carcinoma, Karposi'"'"'s sarcoma, moles dysplastic nevi, lipoma, angioma, dermatofibroma, keloids, psoriasis; and
      
      Adrenal glands;
      
      neuroblastoma.
  - 47. The method of claim 43, further comprising administering at least one additional therapeutic agent appropriate for effecting combination therapy.
  - 48. The method of claim 47 wherein said at least one additional therapeutic agent appropriate for effecting combination therapy is chosen from estrogen receptor modulators, cytostatic/cytotoxic agents, anti-proliferative agents, cell cycle checkpoint inhibitors, angiogenesis inhibitors, monoclonal antibody targeted therapeutic agents, tyrosine kinase inhibitors, serine-threonine kinase inhibitors, histone deacetylase inhibitors, heat shock protein inhibitors, and farnesyl transferase inhibitors.
  - 49. A method of inhibiting at least one ATP-utilizing enzyme in a subject comprising administering to the subject at least one chemical entity of claim 1 or at least one chemical entity chosen from 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(furan-2-ylmethyl)-1-(3-morpholinopropyl)thiourea;
    - 1-(3-hydroxypropyl)-1-((7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-morpholinopropyl)thiourea;
      
      1-(2-(diethylamino)ethyl)-3-(4-fluorophenyl)-1-((7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-(2-hydroxyethyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-phenethylthiourea;
      
      1-(3-(dimethylamino)propyl)-3-(4-fluorophenyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(3-hydroxypropyl)-3-(3-morpholinopropyl)thiourea;
      
      1-(2-hydroxyethyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(1-phenylethyl)thiourea;
      
      1-(2-hydroxyethyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-methoxyphenyl)thiourea;
      
      1-(2-hydroxyethyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-((tetrahydrofuran-2-yl)methyl)thiourea;
      
      3-ethyl-1-(3-hydroxypropyl)-1-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      3-(3-chlorophenyl)-1-(3-(diethylamino)propyl)-1-((7-oxo-2,3,6,7-tetrahydro-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl)thiourea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-(dimethylamino)propyl)thiourea;
      
      3-(3-chlorophenyl)-1-(2-hydroxyethyl)-1-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((7-chloro-6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-(dimethylamino)propyl)-1-(4-fluorobenzyl)thiourea;
      
      3-benzyl-1-(2-hydroxyethyl)-1-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((7-chloro-6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-fluorobenzyl)-3-(2-methoxyethyl)thiourea;
      
      1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-fluorobenzyl)-3-methylthiourea;
      
      1-(4-fluorobenzyl)-1-((7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-methoxypropyl)thiourea;
      
      3-ethyl-1-(4-fluorobenzyl)-1-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-fluorobenzyl)-3-(2-methoxyethyl)thiourea;
      
      1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-methoxybenzyl)-3-(2-methoxyethyl)thiourea;
      
      1-(furan-2-ylmethyl)-1-((6-oxo-5,6-dihydro-[1,3]dioxolo[4,5-g]quinolin-7-yl)methyl)-3-phenylthiourea;
      
      1-benzyl-1-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-phenylthiourea;
      
      3-(furan-2-ylmethyl)-1-(4-methoxybenzyl)-1-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(2-methoxyethyl)thiourea;
      
      1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-methoxybenzyl)-3-(3-morpholinopropyl)thiourea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-(diethylamino)propyl)-1-((6-ethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-(dimethylamino)ethyl)-3-(4-methoxyphenyl)thiourea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-(diethylamino)propyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiourea;
      
      1-((7-chloro-6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(4-fluorobenzyl)-3-(3-morpholinopropyl)thiourea;
      
      3-(2-methoxyethyl)-1-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(3-morpholinopropyl)thiourea;
      
      1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(3-morpholinopropyl)-3-(1-phenylethyl)thiourea;
      
      3-(3-(diethylamino)propyl)-1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(3-hydroxypropyl)thiourea;
      
      3-benzyl-1-((6-ethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)thiourea;
      
      1-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-fluorophenyl)-1-(2-hydroxyethyl)thiourea;
      
      ethyl 4-(N-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-hydroxypropyl)sulfamoyl)benzoate;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-hydroxyethyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methoxy-N-((tetrahydrofuran-2-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-4-methoxy-N-((7-oxo-2,3,6,7-tetrahydro-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl)benzenesulfonamide;
      
      4-chloro-N-(3-hydroxypropyl)-N-((7-oxo-2,3,6,7-tetrahydro-[1,4]dioxino[2,3-g]quinolin-8-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-5-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide;
      
      N-(3-hydroxypropyl)-N-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide;
      
      N-(3-hydroxypropyl)-4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide;
      
      N-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide;
      
      4-tert-butyl-N-((6,7-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-hydroxyethyl)benzenesulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-hydroxypropyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide;
      
      4-chloro-N-(3-hydroxypropyl)-N-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-hydroxyethyl)benzo[c][1,2,5]thiadiazole-4-sulfonamide;
      
      4-acetyl-N-(2-hydroxyethyl)-N-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      methyl 4-(N-cyclohexyl-N-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)sulfamoyl)benzoate;
      
      N-(4-fluorobenzyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-fluoro-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(4-methoxybenzyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-4-methyl-N-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide; and
      
      N-(3-hydroxypropyl)-N-((6-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide;
      
      3-(((benzo[d][1,3]dioxol-5-ylmethyl)(2-hydroxyethyl)amino)methyl)-6,8-dimethylquinolin-2(1H)-one;
      
      3-(((benzo[d][1,3]dioxol-5-ylmethyl)(benzyl)amino)methyl)-6,8-dimethylquinolin-2(1H)-one;
      
      3-(((benzo[d][1,3]dioxol-5-ylmethyl)(cyclohexylmethyl)amino)methyl)-6,8-dimethylquinolin-2(1 H)-one;
      
      1-acetyl-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)piperidine-4-carboxamide;
      
      methyl 5-((benzo[d][1,3]dioxol-5-ylmethyl)((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)amino)-5-oxopentanoate;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-methoxypropanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(diethylamino)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)pentanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-phenylpropanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)cyclopentanecarboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(diethylamino)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)propanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-(dimethylamino)butanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2-phenylacetamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2-(dimethylamino)acetamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)propionamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-methylpiperidine-4-carboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)quinoxaline-6-carboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)furan-2-carboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)cyclohexanecarboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)butyramide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-methyl-1H-pyrrole-2-carboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)pentanamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)cyclopropanecarboxamide;
      
      4-acetamido-N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)isoxazole-5-carboxamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)isobutyramide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-5-methyl-1H-pyrazole-3-carboxamide;
      
      N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-(2-oxopyrrolidin-1-yl)benzyl)propionamide;
      
      N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-(dimethylamino)benzyl)propionamide;
      
      N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methoxyphenethyl)propionamide;
      
      N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methoxybenzyl)propionamide;
      
      N-(2,3-dihydro-1H-inden-1-yl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)propionamide;
      
      N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)propionamide;
      
      N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(pyridin-4-ylmethyl)propionamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)propionamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((2-oxo-1,2-dihydroquinolin-3-yl)methyl)propionamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-(quinolin-3-ylmethyl)propionamide;
      
      2-fluoroethyl benzo[d][1,3]dioxol-5-ylmethyl((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)carbamate;
      
      ethyl benzo[d][1,3]dioxol-5-ylmethyl((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)carbamate;
      
      N-(3-hydroxypropyl)-3,4-dimethoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      4-fluoro-N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      4-chloro-N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2 H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-hydroxypropyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl )-3-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      3-acetyl-N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide;
      
      3-fluoro-N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-(1H-pyrazol-1-yl)benzenesulfonamide;
      
      4-acetyl-N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-3,5-dimethyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-2,5-dimethoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-hydroxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)(phenyl)methanesulfonamide;
      
      4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((tetrahydrofuran-2-yl)methyl)benzenesulfonamide;
      
      4-methoxy-N-(3-methoxypropyl )-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-morpholinopropyl)benzenesulfonamide;
      
      N-butyl-4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-(2-oxopyrrolidin-1-yl)propyl)benzenesulfonamide;
      
      4-methoxy-N-(3-(methyl(phenyl)amino)propyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-(diethylamino)propyl)-4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      4-methoxy-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-(4-methylpiperazin-1-yl)propyl)benzenesulfonamide;
      
      N-(3-methoxypropyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(2-methoxyethyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(pyridin-3-ylmethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-(4-methylpiperazin-1-yl)ethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-benzyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-propyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(furan-2-ylmethyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(2-(4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamido)ethyl)acetamide;
      
      N-(2-hydroxyethyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(pyridin-4-ylmethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(2-(diethylamino)ethyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-ethyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-(4-methylpiperazin-1-yl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-6-phenoxypyridine-3-sulfonamide;
      
      N-(5-(N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)sulfamoyl)-4-methylthiazol-2-yl)acetamide;
      
      N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)thiophene-2-sulfonamide;
      
      4-(3,3-dimethylureido)-N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzenesulfonamide;
      
      N-(3-methoxypropyl)-1,3,5-trimethyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1H-pyrazole-4-sulfonamide;
      
      N-(4-(N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)sulfamoyl)phenyl)acetamide;
      
      N-(4-(N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)sulfamoyl)phenyl)morpholine-4-carboxamide;
      
      N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-(methylsulfonyl)benzenesulfonamide;
      
      N-(3-methoxypropyl)-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-6-morpholinopyridine-3-sulfonamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)ethanesulfonamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methoxybenzenesulfonamide;
      
      N-(benzo[d][1,3]dioxol-5-ylmethyl)-N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide N-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-methoxypropyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-methoxypropyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-methoxypropyl)-4-methyl-N-((2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((2-chloroquinolin-3-yl)methyl)-N-(3-methoxypropyl )-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-methoxypropyl)-4-methyl-N-(quinolin-3-ylmethyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      ethyl 4-(3-(benzo[d][1,3]dioxol-5-ylmethyl)-3-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)ureido)butanoate;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-morpholinopropyl)thiourea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-butyl-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(furan-2-ylmethyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-methoxyphenethyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(2-(thiophen-2-yl)ethyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3-(diethylamino)propyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-methoxypropyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-benzyl-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-methoxybenzyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(3-hydroxypropyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(4-chlorophenyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-propylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-(4-methoxyphenyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-cyclopropyl-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-isopropylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-phenylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-phenylurea;
      
      1-(3,4-dimethoxybenzyl)-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethylurea;
      
      1-benzyl-1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethylurea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethyl-1-(pyridin-4-ylmethyl)urea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethyl-1-(4-methoxybenzyl)urea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethyl-1-(pyridin-3-ylmethyl)urea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethyl-1-(4-methoxyphenethyl)urea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethyl-1-(3-methyl-1H-pyrazol-5-yl)urea;
      
      1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(3-(dimethylamino)benzyl)-3-ethylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-1-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3-ethylurea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-ethyl-1-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-ethyl-1-((2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-ethyl-1-(quinolin-3-ylmethyl)urea;
      
      1-(benzo[d][1,3]dioxol-5-ylmethyl)-3-ethyl-1-((2-methoxypyridin-3-yl)methyl)urea;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-4-methyl-N-((2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-4-methyl-N-((1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(1-methylpiperidin-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(4-hydroxybutyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(tetrahydro-2H-pyran-4-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(Exo-bicyclo[2.2.1]heptan-2-yl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(3-(4-methylpiperazin-1-yl)propyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-butyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclopentyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isobutyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(2-cyanoethyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(4-(dimethylamino)butyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-N-((2-methoxyquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(trans-4-hydroxycyclohexyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      2-(4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamido)acetic acid;
      
      N-cyclopropyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-(dimethylamino)-2,2-dimethylpropyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(tetrahydro-1h-3λ
      
      6-thiophene-11-dione)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-(4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamido)butanoic acid, 4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((1-methylpiperidin-4-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclohexyl-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-butyl-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclopentyl-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((trans)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((trans)-4-hydroxycyclohexyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((1R,2S)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((1S,2S)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((cis)-2-hydroxycyclohexyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((trans)-2-hydroxycyclohexyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((1R,2R)-2-hydroxycyclopentyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonamide;
      
      N-((trans)-2-hydroxycyclopentyl)-N-((7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((trans)-4-aminocyclohexyl)-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      tert-butyl (trans)-4-(N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamido)cyclohexylcarbamate;
      
      N-isopropyl-N-((7-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-N-((8-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      tert-butyl 3-(N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamido)cyclohexylcarbamate;
      
      N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ylsulfonyl)pentanamide;
      
      N-((7,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((trans)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((trans)-2-hydroxycyclopentyl)-N-((8-methoxy-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(3-aminocyclohexyl)-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((1R,2R)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonamide;
      
      N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ylsulfonyl)cyclopentanecarboxamide;
      
      N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ylsulfonyl)acetamide;
      
      N-((1S,2S)-2-hydroxycyclopentyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonamide;
      
      2-hydroxy-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-ylsulfonyl)pentanamide;
      
      N-((8-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-((trans)-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((5,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((8-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-isopropyl-4-methyl-N-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((trans)-2-hydroxycyclopentyl)-4-methyl-N-((7-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide, N-isopropyl-4-methyl-N-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(trans-2-hydroxycyclopentyl)-4-methyl-N-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((5,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(trans-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclobutyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclobutyl-N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(cis-2-hydroxycyclopentyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(cis-2-hydroxycyclopentyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((7,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(cis-4-hydroxycyclohexyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-cyclohexyl-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(trans-2-hydroxycyclohexyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-(cis-2-hydroxycyclohexyl)-4-methyl-N-((8-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide;
      
      N-((8-ethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-isopropyl-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide; and
      
      N-isopropyl-N-((8-isopropyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-4-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide, and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof.
  - 50. The method of claim 49 wherein the at least one ATP-utilizing enzyme is chosen from a human protein kinase.
  - 51. The method of claim 50 wherein the human protein kinase is chosen from Aurora A, Aurora B, Aurora C, CDK2/cyclinE, CHEK2, GSK3-α
    - , GSK3-β
      
      , INSR, KDR, MAPK1, MAPKAPK3, MET, MSK1, MSK2, PAK2, P38α
      
      , PRAK, PDGFR-α
      
      , PLK1, ROCK2, SYK, and ZAP70.
  - 52. The method of claim 51 wherein the human protein kinase is chosen from Aurora A, Aurora B, and Aurora C.
  - 53. A packaged pharmaceutical formulation comprising a pharmaceutical composition of claim 37 and instructions for using the composition to treat a mammal.
  - 54. The packaged pharmaceutical formulation of claim 53 wherein the instructions are for using the pharmaceutical composition to treat a patient suffering from a disease responsive to inhibition at least one ATP-utilizing enzyme.
  - 55. The packaged pharmaceutical formulation of claim 54 wherein said at least one ATP-utilizing enzyme is chosen from Aurora Ai Aurora B, Aurora C, CDK2/cyclinE, CHEK2, GSK3-α
    - , GSK3-β
      
      , INSR, KDR, MAPK1, MAPKAPK3, MET, MSK1, MSK2, PAK2, P38α
      
      , PRAK, PDGFR-α
      
      , PLK1, ROCK2, SYK, and ZAP70.
  - 56. The packaged pharmaceutical formulation of claim 55 wherein said at least one ATP-utilizing enzyme is chosen from Aurora A, Aurora B, and Aurora C.

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Litigation Campaign Assessment

Current Assignee
Agrius Group, LLC
Original Assignee
Agrius Group, LLC
Inventors
Dickson, John, Hodge, Carl, Chen, Ke

Application Number

US11/803,140
Publication Number

US 20070287706A1
Time in Patent Office

Days
Field of Search
US Class Current

514/230.500
CPC Class Codes

A61P 11/06   Antiasthmatics

A61P 17/06   Antipsoriatics

A61P 19/02   for joint disorders, e.g. a...

A61P 25/16   Anti-Parkinson drugs

A61P 25/28   for treating neurodegenerat...

A61P 27/02   Ophthalmic agents

A61P 27/06   Antiglaucoma agents or miotics

A61P 3/04   Anorexiants; Antiobesity ag...

A61P 3/10   for hyperglycaemia, e.g. an...

A61P 31/04   Antibacterial agents

A61P 31/10   Antimycotics

A61P 31/12   Antivirals

A61P 35/00   Antineoplastic agents

A61P 35/02   specific for leukemia

A61P 35/04   specific for metastasis

A61P 9/00   Drugs for disorders of the ...

C07D 215/22   attached in position 2 or 4

C07D 215/227   only one oxygen atom which ...

Certain substituted quinolones, compositions, and uses thereof

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Abstract

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Certain substituted quinolones, compositions, and uses thereof

First Claim

6 Assignments

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Abstract

23 Citations

56 Claims

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