Methods and systems for administering an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders

• US 20070287931A1
• Filed: 02/14/2007
• Published: 12/13/2007
• Est. Priority Date: 02/14/2006
• Status: Abandoned Application

• Current Assignee: Cyberonics, Inc
• Original Assignee: Cyberonics, Inc
• Inventors: Dilorenzo, Daniel
• Application Number:
  US11/706,630
• Publication Number:
  US 20070287931A1
• Time in Patent Office: Days
• US Class Current: 600/545
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: A61K 31/5513 1,4-Benzodiazepines, e.g. diazepam or clozapine
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants

Abstract

The present invention provides systems and methods for managing epilepsy. In one embodiment, a method of the present invention characterize a patient'"'"'s propensity for a future epileptic seizure and facilitates administration of a pharmacological agent. The dosage of the pharmacological agent is typically a function of at least one of the patient'"'"'s propensity for the future epileptic seizure and time period to seizure.

Claims

1. A method of managing epileptic seizures, the method comprising:

determining that a patient has an increased propensity for having a future epileptic seizure within a time period prior to the occurrence of the epileptic seizure; and

providing an output communication to the patient that indicates to the patient a therapeutically effective dosage of a pharmacological agent treatment to be administered that will provide a clinically therapeutic threshold amount of the pharmacological agent within the time period prior to the occurrences of the epileptic seizure;

wherein the therapeutically effective dosage is less than a dosage that is effective after the seizure has begun.

2. The method of claim 1 wherein the therapeutically effective dosage is a function of the time period prior to the occurrence of the epileptic seizure.

3. The method of claim 1 wherein the therapeutically effective dosage is a function of the patient'"'"'s propensity for having a future seizure.

4. The method of claim 1 wherein the time period is between about 30 seconds and about 60 minutes.

5. The method of claim 1 wherein the therapeutically effective dosage is less than about 70% of the dosage that is effective after the seizure has begun.

6. The method of claim 1 wherein the therapeutically effective dosage is less than about 50% of the dosage that is effective after the seizure has begun.

7. The method of claim 1 wherein the therapeutically effective dosage is less than about 35% of the dosage that is effective after the seizure has begun.

8. The method of claim 1 wherein the therapeutically effective dosage is less than about 25% of the dosage that is effective after the seizure has begun.

9. The method of claim 1 wherein the therapeutically effective dosage is less than about 10% of the dosage that is effective after the seizure has begun.

10. The method of claim 1 wherein the therapeutically effective dosage is less than about 5% of the dosage that is effective after the seizure has begun.

11. The method of claim 1, further comprising manually administering the therapeutically effective dosage.

12. A method of administering a pharmacological agent for treating epileptic seizures, the method comprising:

determining that a patient has an increased propensity for having an epileptic seizure within a time period prior to the occurrences of the epileptic seizure; and

facilitating an acute administration of a therapeutically effective dosage of benzodiazepine that provides a clinical threshold amount of the benzodiazepine within the time period prior to the occurrence of the epileptic seizure.

13. The method of claim 12 wherein facilitating administration comprises providing an output communication to the patient that is indicative of the administration of the therapeutically effective dosage to the patient.

14. The method of claim 12 wherein facilitating an acute administration comprises automatically delivering the benzodiazepine to the patient.

15. The method of claim 14 wherein automatically delivering the benzodiazepine comprises delivering the benzodiazepine using an implanted drug pump.

16. The method of claim 12 wherein facilitating an acute administration comprises activating a drug delivery device.

17. The method of claim 12 wherein the benzodiazepine is midazolam.

18. The method of claim 17 wherein facilitating an acute administration comprises administering the midazolam in a buccal, intranasal, or intramuscular formulation.

21. The method of claim 12 wherein the benzodiazepine is lorazepam.

22. The method of claim 21 wherein facilitating an acute administration comprises administering the lorazepam in an intravenous formulation.

19. The method of 12 wherein the benzodiazepine is diazepam.

20. The method of claim 19 wherein facilitating an acute administration comprises administering the diazepam in an intravenous formulation.

23. A method of managing epileptic seizures, the method comprising:

determining that a patient has an increased propensity of a future epileptic seizure within a time period prior to the occurrence of the epileptic seizure; and

providing an output communication to the patient that is indicative of a therapeutically effective dosage of a pharmacological agent treatment that will provide a clinically therapeutic threshold amount of the pharmacological agent within the time period prior to the occurrences of the epileptic seizure.

24. The method of claim 23 further comprising administering the therapeutically effective dosage of the pharmacological agent.

25. The method of claim 24 wherein administering the therapeutically effective dosage of the pharmacological agent comprises manually administering the therapeutically effective dosage of the pharmacological agent.