Transdermal System for Sustained Delivery of Polypeptides
First Claim
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1. A system for facilitating transdermal delivery of an active agent through skin of a subject comprising:
- an apparatus capable of generating at least one micro-channel in an area on the skin of the subject, and a patch comprising at least one drug reservoir layer, the at least one drug reservoir layer comprising a polymeric matrix and a pharmaceutical composition comprising as an active agent at least one therapeutic or immunogenic peptide, polypeptide, or protein.
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Abstract
A transdermal system for sustained delivery of high molecular weight hydrophilic drugs, especially peptide-, polypeptide- or protein-drugs, and methods of use thereof, are provided. The system includes an apparatus that generates micro-channels in the skin of a subject in combination with a transdermal patch comprising at least one drug reservoir layer comprising a polymeric matrix and a therapeutic or immunogenic peptide, polypeptide, or protein. The system provides sustained delivery of therapeutic or immunogenic agents, thereby achieving sustained therapeutic blood concentrations of these agents.
64 Citations
51 Claims
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1. A system for facilitating transdermal delivery of an active agent through skin of a subject comprising:
- an apparatus capable of generating at least one micro-channel in an area on the skin of the subject, and a patch comprising at least one drug reservoir layer, the at least one drug reservoir layer comprising a polymeric matrix and a pharmaceutical composition comprising as an active agent at least one therapeutic or immunogenic peptide, polypeptide, or protein.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
- 22. A patch adapted for transdermal delivery of an active agent comprising at least one drug reservoir layer, the at least one drug reservoir layer comprising a polymeric matrix and a pharmaceutical composition comprising as an active agent a therapeutic or immunogenic peptide, polypeptide, or protein.
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34. A method for sustained transdermal delivery of a therapeutic or immunogenic agent, the method comprising:
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a. generating at least one micro-channel in a region on the skin of a subject;
b. affixing a patch to the region of skin in which the at least one micro-channel is present, the patch comprising at least one drug reservoir layer, wherein the drug reservoir layer comprises a polymeric matrix and a pharmaceutical composition comprising a therapeutic or immunogenic peptide, polypeptide, or protein; and
c. achieving a therapeutic blood concentration of the peptide, polypeptide, or protein for at least 6 hours. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51)
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Specification