MICRODIALYSIS PROBE
First Claim
Patent Images
1. A microdialysis probe comprising:
- a rigid housing having a lumen and a working end;
an aperture in fluid communication with the lumen at said working end;
a plurality of tubes extending longitudinally through said lumen, each of said plurality of tubes having a terminal opening, said terminal openings being in fluid communication with the lumen near said working end; and
, a semipermeable membrane disposed within said lumen and located between said aperture and said terminal openings.
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Accused Products
Abstract
Provided are novel devices, systems, and methods for performing microanalysis of a localized biochemical milieu, and/or for highly localized drug delivery and treatment evaluation.
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Citations
37 Claims
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1. A microdialysis probe comprising:
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a rigid housing having a lumen and a working end;
an aperture in fluid communication with the lumen at said working end;
a plurality of tubes extending longitudinally through said lumen, each of said plurality of tubes having a terminal opening, said terminal openings being in fluid communication with the lumen near said working end; and
,a semipermeable membrane disposed within said lumen and located between said aperture and said terminal openings. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A microdialysis probe comprising:
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a hollow bore needle having a proximal end and a distal end, the proximal end including a substantially rounded hollow tip;
a membrane disposed within said hollow bore needle at said proximal end; and
first and second tubing at least partially disposed within said hollow bore needle and in fluid communication with said membrane. - View Dependent Claims (12, 13, 14)
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15. A microdialysis system comprising:
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a probe, comprising a rigid housing having a lumen and a working end;
an aperture in fluid communication with the lumen at said working end;
a plurality of tubes extending longitudinally through said lumen, each of said plurality of tubes having a terminal opening, said terminal openings being in fluid communication with the lumen near said working end; and
,a semipermeable membrane disposed within said lumen and located between said aperture and said terminal openings;
a pump in fluid communication with at least one of said plurality of tubes; and
,a sample collector in fluid communication with at least one other of said plurality of tubes. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method comprising:
contacting a tissue with a microdialysis probe, said probe comprising a rigid housing having a lumen and a working end;
an aperture in fluid communication with the lumen at said working end;
a plurality of tubes extending longitudinally through said lumen, each of said plurality of tubes having a terminal opening, said terminal openings being in fluid communication with the lumen near said working end; and
,a semipermeable membrane disposed within said lumen and located between said aperture and said terminal openings;
a semipermeable membrane disposed transversely within said internal space, located distally from said aperture and proximally from each of the terminal openings of said plurality of lumens. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
Specification