Coating System, Articles and Assembly Using the Same and Methods of Reducing Sticktion

• US 20070287954A1
• Filed: 03/29/2007
• Published: 12/13/2007
• Est. Priority Date: 03/30/2006
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Liu, Yongming, Zhao, Xia
• Granted Patent: US 8,075,995 B2
• Time in Patent Office: Days
• US Class Current: 604/93.10
• CPC Class Codes: A61F 2/00 Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents as cosmetic articles, see the relevant subclasses, e.g. wigs, hair pieces, A41G3/00, A41G5/00; artificial nails A45D31/00; dental prostheses A61C13/00; materials for prostheses A61L27/00; artificial hearts A61M60/00; artificial kidneys A61M1/14
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61M 2205/0238 the material being a coating or protective layer
• CPC Class Codes: C08G 77/20 containing silicon bound to unsaturated aliphatic groups C08G77/045 takes precedence
• CPC Class Codes: C08L 83/00 Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
• CPC Class Codes: C09D 183/04 Polysiloxanes
• CPC Class Codes: Y10T 428/1352 Polymer or resin containing [i.e., natural or synthetic]
• CPC Class Codes: Y10T 428/2962 Silane, silicone or siloxane in coating
• CPC Class Codes: Y10T 428/31612 As silicone, silane or siloxane
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane

Abstract

The present invention provides a coating system for an article including a first component having a surface in frictional engagement with a surface of a second component, wherein at least a portion of at least one surface of the component(s) is coated with a coating prepared from a composition including a first, curable organopolysiloxane comprising at least two alkenyl groups; and a second, curable organopolysiloxane comprising at least two polar groups, the second organopolysiloxane being different from the first organopolysiloxane, which can provide low breakloose force when used in syringe assemblies.

Claims

1. A coating system for an article comprising a first component having a surface in frictional engagement with a surface of a second component, wherein at least a portion of at least one surface of the component(s) is coated with a coating prepared from a composition comprising:

(a) a first, curable organopolysiloxane comprising at least two alkenyl groups; and

(b) a second, curable organopolysiloxane comprising at least two polar groups, the second organopolysiloxane being different from the first organopolysiloxane.

2. The coating system according to claim 1, wherein the article is a medical device selected from the group consisting of syringe assemblies, syringe pumps, drug cartridges, needleless injectors, liquid dispensing devices and liquid metering devices.

3. The coating system according to claim 2, wherein the medical device is a syringe assembly comprising a first component which is a syringe barrel and a second component which is a sealing member.

4. The coating system according to claim 1, wherein the first component is formed from glass, metal, ceramic, plastic, rubber or combinations thereof.

5. The coating system according to claim 4, wherein the first component is prepared from an olefinic polymer.

6. The coating system according to claim 5, wherein the olefinic polymer is selected from the group consisting of polyethylene, polypropylene, poly(1-butene), poly(2-methyl-1-pentene) and cyclic polyolefins.

7. The coating system according to claim 1, wherein the second component is a sealing member selected from the group consisting of a stopper, O-ring, plunger tip and piston.

8. The coating system according to claim 1, wherein the second component is prepared from a rubber material.

9. The coating system according to claim 8, wherein the rubber material is butyl rubber.

10. The coating system according to claim 1, wherein at least a portion of a surface of the first component and at least a portion of a surface of the second component are coated with the coating according to claim 1.

11. The coating system according to claim 1, wherein the first component is prepared from a non-cyclic polyolefin, the portion of the surface of the first component is uncoated, and the portion of the surface of the second component is coated with the coating according to claim 1.

12. The coating system according to claim 1, wherein each alkenyl group of the first organopolysiloxane (a) is independently selected from the group consisting of vinyl, allyl, propenyl, butenyl, pentenyl, hexenyl, heptenyl, octenyl, nonenyl and decenyl.

13. The coating system according to claim 1, wherein at least one alkenyl group of the first organopolysiloxane (a) is vinyl.

14. The coating system according to claim 1, wherein the first organopolysiloxane (a) is (7.0-8.0% vinylmethylsiloxane)—

dimethylsiloxane copolymer, trimethylsiloxy terminated.

15. The coating system according to claim 1, wherein the first organopolysiloxane (a) comprises about 10 to about 80 weight percent of the composition.

16. The coating system according to claim 1, wherein each polar group of the second organopolysiloxane (b) is independently selected from the group consisting of acrylate, methacrylate, amino, imino, hydroxy, epoxy, ester, alkyloxy, isocyanate, phenolic, polyurethane oligomeric, polyamide oligomeric, polyester oligomeric, polyether oligomeric, polyol, carboxypropyl, and fluoro groups.

17. The coating system according to claim 1, wherein the organopolysiloxane (b) is [15-20% (acryloxypropyl)methylsiloxane]—

dimethylsiloxane copolymer.

18. The coating system according to claim 1, wherein the second organopolysiloxane (b) comprises about 1 to about 40 weight percent of the composition.

19. The coating system according to claim 1, wherein the composition further comprises an organopolysiloxane selected from the group consisting of an alkyl siloxane and an organopolysiloxane comprising at least two pendant hydrogen groups, the organopolysiloxane being different from the first and second organopolysiloxanes.

20. The coating system according to claim 1, wherein the coating is at least partially cured by irradiation with an isotope or electron beam.

21. The coating system according to claim 1, wherein the composition is essentially free of moisture-curable siloxanes.

22. The coating system according to claim 21, wherein the moisture-curable siloxane comprises at least two hydroxyl groups.

23. An article of manufacture comprising a first component having a surface in frictional engagement with a surface of a second component, wherein at least a portion of at least one surface of the component(s) is coated with the coating system according to claim 1.

24. A syringe assembly according to claim 3, wherein the syringe barrel is prepared from polypropylene and the sealing member is prepared from butyl rubber, the surface of the syringe barrel being uncoated and the at least one portion of the surface of the sealing member being coated with the coating system.

25. A syringe assembly according to claim 3, wherein the syringe barrel is prepared from polypropylene and the sealing member is prepared from butyl rubber, the at least one portion of the surface of the sealing member being coated with the coating system.

26. A method for lubricating the interface between a first component having a surface in frictional engagement with a surface of a second component, comprising the steps of:

(a) applying a coating system according to claim 1 to at least a portion of at least one surface of the component(s) to form a coating upon the portion of the surface; and

(b) irradiating the coating of step (a) to at least partially cure the coating.

27. A method for reducing breakout force of a surface adapted for slidable engagement with another surface comprising:

(a) applying a coating system according to claim 1 to at least a portion of at least one surface to form a coating upon the portion of the surface; and

(b) irradiating the coating of step (a) to at least partially cure the coating.

28. A method for reducing sustaining force of a surface adapted for slidable engagement with another surface comprising:

(a) applying a coating system according to claim 1 to at least a portion of at least one surface to form a coating upon the portion of the surface; and

(b) irradiating the coating of step (a) to at least partially cure the coating.

29. A method for reducing breakout and sustaining forces of slidable surfaces in the interior of a syringe assembly comprising:

(a) applying a coating system according to claim 1 to the interior wall of the syringe barrel to form a coating thereon; and

(b) irradiating the coating of step (a) to at least partially cure the coating.