Media conditioned by human embryonic stem cells or other progenitor cells and uses therefor

• US 20070292400A1
• Filed: 02/15/2007
• Published: 12/20/2007
• Est. Priority Date: 02/16/2006
• Status: Abandoned Application

• Current Assignee: Burnham Institute For Medical Research
• Original Assignee: Burnham Institute For Medical Research
• Inventors: Terskikh, Alexey, Lipton, Stuart
• Application Number:
  US11/707,367
• Publication Number:
  US 20070292400A1
• Time in Patent Office: Days
• US Class Current: 424/93.7
• CPC Class Codes: A61K 35/545 Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
• CPC Class Codes: A61K 8/982 Reproductive organs; Embryos, Eggs
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations
• CPC Class Codes: C12N 2500/90 Serum-free medium, which may still contain naturally-sourced components
• CPC Class Codes: C12N 2501/115 Basic fibroblast growth factor (bFGF, FGF-2)
• CPC Class Codes: C12N 2501/33 Insulin together with transferrin C12N2500/25; Insulin-like growth factors C12N2501/105
• CPC Class Codes: C12N 2502/02 embryonic cells
• CPC Class Codes: C12N 2533/52 Fibronectin; Laminin
• CPC Class Codes: C12N 2533/54 Collagen; Gelatin
• CPC Class Codes: C12N 5/0606 Pluripotent embryonic cells, e.g. embryonic stem cells [ES] embryonic germ cells C12N5/0611, induced pluripotent stem cells C12N5/0696

Abstract

Compositions for application to the skin of individuals in need thereof are provided that include media conditioned by the growth of human embryonic stem cells.

Claims

1. A composition for administration to skin of an individual, the composition comprising an amount of a medium conditioned by growth of embryonic stem cells that is effective to provide an improvement in the health or appearance of the skin of the individual and a suitable vehicle.

2. The composition of claim 1 wherein the embryonic stem cells are human embryonic stem cells.

3. The composition of claim 2 that is substantially free from non-human animal products.

4. The composition of claim 1 wherein the improvement in the appearance or health of the skin of the individual is an improvement in a member of the group consisting of wrinkling, folds, sagging, age spots, uneven pigmentation, thinning, elasticity, scarring, surface roughness, surface roughness, surface vessels, redness, and pore size.

5. A method of treating skin of an individual in need thereof comprising administering to the skin of the individual a composition comprising an amount of a medium conditioned by growth of human embryonic stem cells that is effective to provide an improvement in the appearance or health of the skin of the individual and a suitable vehicle.

6. The method of claim 5 wherein the embryonic stem cells are human embryonic stem cells.

7. The method of claim 6 wherein the composition is substantially free from non-human animal products.

8. The method of claim 5 wherein the improvement in the appearance or health of the skin of the individual is an improvement in a member of the group consisting of wrinkling, folds, sagging, age spots, uneven pigmentation, thinning, elasticity, scarring, surface roughness, surface roughness, surface vessels, redness, and pore size.

9. A method of making a composition for treatment of skin of an individual in need thereof comprising combining an amount of a medium conditioned by growth of embryonic stem cells that is effective to provide an improvement in the appearance or health of the skin of the individual and a suitable vehicle.

10. The method of claim 9 wherein the embryonic stem cells are human embryonic stem cells.

11. The method of claim 10 wherein the composition is substantially free from non-human animal products.

12. A use of a medium conditioned by growth of embryonic stem cells to prepare a medicament for administration to skin of an individual in need thereof.

13. A kit comprising a composition comprising:

(a) composition for administration to skin of an individual, the composition comprising an amount of a medium conditioned by growth of embryonic stem cells that is effective to provide an improvement in the appearance or health of the skin of the individual and a suitable vehicle; and

(2) suitable packaging.

14. The kit of claim 13 wherein the embryonic stem cells are human embryonic stem cells.

15. The kit of claim 14 wherein the composition is substantially free from non-human animal products.