Structure for modulating intraocular pressure

• US 20070292474A1
• Filed: 05/31/2007
• Published: 12/20/2007
• Est. Priority Date: 12/20/2002
• Status: Active Grant

• Current Assignee: Life Spring Biotech Co., Ltd.
• Original Assignee: Life Spring Biotech Co., Ltd.
• Inventors: Hsu, Wei-Cherng, Hsiao, Jo-Yi, Yen, Hsiao-Cheng
• Granted Patent: US 7,544,368 B2
• Time in Patent Office: Days
• US Class Current: 424/427
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61L 2430/16 for reconstruction of eye parts, e.g. intraocular lens, cornea
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: C08L 5/00 Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin
• CPC Class Codes: Y10S 435/81 Packaged device or kit

Abstract

Embodiments of the present invention are directed to three-dimensional porous structures for modulating intraocular pressure. The structures can include a mixture of copolymers, for example, collagen and glycosaminoglycan.

Claims

1. A scaffold comprising at least two copolymers in an amount that produces:

a saturated static pressure of about 0.5 mmHg to about 5.5 mmHg, after saturation in saline; and

a stiffness of about 0.5 KPa to about 2 KPa after saturation in saline.

2. The scaffold of claim 1, wherein the saturated static pressure is about 1.75 mmHg to about 3.5 mmHg.

3. The scaffold of claim 1, wherein said scaffold has a stiffness of 1 KPa to 1.6 KPa.

4. The scaffold of claim 2, wherein said scaffold has a stiffness of 1 KPa to 1.6 KPa.

5. The scaffold of claim 1, wherein said scaffold has a stiffness of 0.5 KPa to 2 KPa.

6. The scaffold of claim 2, wherein said scaffold has a stiffness of 0.5 KPa to 2 KPa.

7. The scaffold of claim 1, wherein the copolymers of said scaffold comprise collagen or gelatin.

8. The scaffold of claim 1, wherein the copolymers of said scaffold comprise a glycosaminoglycan selected from the group consisting of chondroitin-6-sulfate, chondrotin-4-sulfate, heparin, heparan sulfate, keratan sulfate, dermatan sulfate, chitin, chitosan, and mixtures thereof.

9. The scaffold of claim 1, wherein one of the copolymers is type I collagen.

10. The scaffold of claim 1, wherein the scaffold has a pore size of about 10 μ

m to about 300 μ

m.

11. A kit comprising the scaffold of claim 1.

12. A scaffold comprising collagen and a glycosaminoglycan, wherein the scaffold has a saturated static pressure of about 1 mmHg to about 4 mmHg.

13. A kit comprising the scaffold of claim 12.

14. A scaffold comprising collagen and a glycosaminoglycan, wherein the scaffold has a pore size of about 10 μ

m to about 300 μ

m.

15. The scaffold of claim 14, wherein the pore size is about 20 μ

m to about 200 μ

m.

16. A kit comprising the scaffold of claim 15.