METHOD FOR TREATMENT OF WOUND TREATMENT USING AGANOCIDES

• US 20070292489A1
• Filed: 06/14/2007
• Published: 12/20/2007
• Est. Priority Date: 06/14/2006
• Status: Abandoned Application

• Current Assignee: NovaBay Pharmaceuticals, Inc.
• Original Assignee: NovaBay Pharmaceuticals, Inc.
• Inventors: Bassiri, Mansour, Najafi, Ramin, Khosrovi, Behzad
• Application Number:
  US11/763,368
• Publication Number:
  US 20070292489A1
• Time in Patent Office: Days
• US Class Current: 424/445
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/20 Elemental chlorine; Inorganic compounds releasing chlorine
• CPC Class Codes: A61M 1/916 specially adapted for deep wounds
• CPC Class Codes: A61M 1/92 with liquid supply means
• CPC Class Codes: A61M 1/962 having pumping means on the suction site, e.g. miniature pump on dressing or dressing capable of exerting suction
• CPC Class Codes: A61M 27/00 Drainage appliance for wounds or the like , i.e. wound drains, implanted drains negative pressure wound therapy devices A61M1/90; implements for holding wound open A61B17/02 ; middle ear drainage A61F11/202
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

Provided herein is a method for the treatment of a wound using a wound treatment regimen for treating a chronic wound, the regimen comprising: a) applying reduced pressure to the wound; and b) treating the wound with a substantially non-toxic, non-irritating organic aganocide composition while applying reduced pressure to the wound.

Claims

1. A method for the treatment of a chronic wound using a wound treatment regimen, the regimen comprising:

a) applying reduced pressure to the wound;

b) treating the wound with a substantially non-toxic, non-irritating organic aganocide composition while applying reduce pressure to the wound;

c) optionally, treating the wound with saline after at least one aganocide treatment step, wherein steps a), b) and c) together comprising a regimen cycle; and

d) optionally, repeating at least one additional treatment regimen cycle.

2. The method of claim 1, wherein the organic aganocide composition is selected from the group consisting of an N-halo amino acid, an N,N-dihaloamino acid, a source of an N-halo amino acid, a source of an N,N-dihaloamino acid and mixtures thereof.

3. The method of claim 1, wherein the treatment of the aganocide to the wound is performed before the application of reduced pressure to the wound.

4. The method of claim 1, wherein the aganocide treatment of the wound is done after a first application of reduced pressure to the wound.

5. The method of claim 1, wherein the saline treatment is performed in conjunction with applying the reduced pressure.

6. The method of claim 2, wherein aganocide treatment and the application of reduced pressure is done intermittently.

7. The method of claim 1, wherein each aganocide treatment step is followed by a reduced pressure application step, followed by a second aganocide treatment step, followed by a second reduced pressure application step, this sequence of steps being considered a single treatment cycle.

8. The method of claim 7, comprising a single treatment cycle or at least two single treatment cycles.

9. The method of claim 7, comprising at least four, six, ten, twelve or 24 but not more than 48 single treatment cycles.

10. The method of claim 1, wherein the aganocide is an N-halo amino acid or an N,N-dihaloamino acid.

11. The method of claim 1, wherein the treatment with the aganocide is performed by an automated delivery system.

12. The method of claim 10, wherein the N-halo amino acid or an N,N-dihaloamino acid composition has a pH from about 3.5 to 7.

13. A method for the treatment of a chronic wound using a wound treatment regimen, the regimen comprising:

a) treating the wound with at least one application of a substantially non-toxic, non-irritating organic aganocide composition;

b) treating the wound with saline; and

c) applying reduced pressure to the wound.

14. The method of claim 13, wherein the organic aganocide composition is selected from the group consisting of an N-halo amino acid, an N,N-dihaloamino acid, a source of an N-halo amino acid, a source of an N,N-dihaloamino acid and mixtures thereof.

15. The method of claim 13, wherein the treatment of the aganocide to the wound is performed before the application of reduced pressure to the wound.

16. The method of claim 13, wherein the aganocide treatment of the wound is done after a first application of reduced pressure to the wound.

17. The method of claim 13, wherein the saline treatment is performed in conjunction with applying the reduced pressure.

18. The method of claim 14, wherein aganocide treatment and the application of reduced pressure is done intermittently.

19. The method of claim 13, wherein each aganocide treatment step is followed by a reduced pressure application step, followed by a second aganocide treatment step, followed by a second reduced pressure application step, this sequence of steps being considered a single treatment cycle.

20. The method of claim 19, comprising a single treatment cycle or at least two single treatment cycles.

21. The method of claim 19, comprising at least four, six, ten, twelve or 24 but not more than 48 single treatment cycles.

22. The method of claim 13, wherein the treatment of the wound with saline is applied after at least one aganocide treatment and one reduced pressure application step.

23. A method for promoting wound healing of a mammalian patient having a wound using a treatment regimen, wherein the regimen comprises:

a) a short term application comprising contacting the wound with a cell-compatible aganocide composition in an amount effective to promote wound healing;

b) a long term application comprising contacting the wound with an effective amount of the aganocide composition to promote wound healing, wherein the short term application and the long term application are performed at alternating time intervals to promote wound healing and appropriate to the patient in need of wound care; and

c) applying reduced pressure to the wound for a sufficient period of time to promote wound healing.

24. The method of claim 23, wherein the organic aganocide composition is selected from the group consisting an N-chlorotaurine, N,N-dichlorotaurine and a compound of the formula

A-C(R¹R⁰)R(CH₂)_n—

C(YZ)—

X′

 

 

(I)

or a derivative thereof, wherein A is hydrogen, HalNH—

or Hal₂N—

wherein Hal is halogen selected from the group consisting of chloro and bromo;

R is a carbon single bond or a divalent cycloalkylene radical with three to six carbon atoms, R¹ is hydrogen, lower alkyl or the group —

COOH;

R⁰ is hydrogen or lower alkyl;

n is 0 or an integer from 1 to 13, or R¹ and R⁰ together with the carbon atom to which they attach form a (C₃-C₆)cycloalkyl ring;

Y is hydrogen, lower alkyl or —

NH₂ or —

NHal₂; and

Z is hydrogen or lower alkyl; and

X′

is hydrogen, —

COOH, —

CONH₂, —

SO₃H, —

SO₂NH₂ or —

P(═

O)(OH)₂, a salt thereof, a derivative thereof, and mixtures thereof.

25. The method of claim 23, wherein the short term and/or long term application of the aganocide to the wound is performed before the application of reduced pressure to the wound.

26. The method of claim 23, wherein the short term and/or long term application of the aganocide to the wound is done after a first application of reduced pressure to the wound.

27. The method of claim 23, wherein the saline treatment is performed in conjunction with applying the reduced pressure.

28. The method of claim 24, wherein short term and/or the long term application of the aganocide and the application of reduced pressure is done intermittently.

29. The method of claim 23, wherein each of the short term and/or each of the long term aganocide application step is followed by a reduced pressure application step, followed by a second short term and/or long term aganocide application step, followed by a second reduced pressure application step, this sequence of steps being considered a single treatment cycle.

30. The method of claim 29, comprising one treatment cycle or at least two single treatment cycles.

31. The method of claim 29, comprising at least four, six, ten, twelve or 24 but not more than 48 single treatment cycles.

32. The method of claim 23, wherein the aganocide is selected from the group consisting of N-chlorotaurine, N,N-dichlorotaurine, N, N-dichloro-2,2-dimethyltaurine, a salt thereof, and mixtures thereof.

33. The method of claim 23, wherein the treatment with the aganocide is performed by an automated delivery system.

34. The method of claim 32, wherein the aganocide composition has a pH from about 3.5 to 7.

35. The method of claim 32, wherein the aganocide further includes HOCl or an HOCl source.

36. The method of claim 32, wherein the amount of aganocide is between about 100 to about 10,000 ppm, about 200 ppm to about 2,000 ppm, or about 400 ppm to about 1,000 ppm.

37. The method of claim 35, wherein the amount of HOCl is from about 20 ppm to 500 ppm, about 40 ppm to 250 ppm or about 50 ppm to 150 ppm.

38. The method of claim 29, wherein the pH of the aganocide composition is from about 2 to 9.5, or about 3.5 to 6.5.