Method and CMOS-based device to analyze molecules and nanomaterials based on the electrical readout of specific binding events on functionalized electrodes
First Claim
1. A device comprising a functionalized electrode having a probe molecule, wherein the device has an ability to electrically detect a molecular binding event between the probe molecule and a target molecule by a polarization change of the functionalized electrode.
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Abstract
A device having a functionalized electrode having a probe molecule, wherein the device has an ability to electrically detect a molecular binding event between the probe molecule and a target molecule by a polarization change of the functionalized electrode is disclosed. The device could also include an unfunctionalized electrode that does not have the probe molecule and the device could have an ability to electrically detect the molecular binding event between the probe molecule and the target molecule by a polarization change between the functionalized electrode and the unfuctionalized electrode.
74 Citations
60 Claims
- 1. A device comprising a functionalized electrode having a probe molecule, wherein the device has an ability to electrically detect a molecular binding event between the probe molecule and a target molecule by a polarization change of the functionalized electrode.
- 11. A method of manufacturing a device comprising functionalizing a first electrode with a probe molecule to form a functionalized electrode and not functionalizing a second electrode to form an unfunctionalized electrode, wherein the device has an ability to electrically detect a molecular binding event between the probe molecule and a target molecule by a polarization change between the functionalized electrode and the unfunctionalized electrode.
- 16. A method of measuring a molecular binding event between a probe molecule and a target molecule, comprising obtaining a device comprising an unfunctionalized electrode and a functionalized electrode having the probe molecule, and detecting the molecular binding event between the probe molecule and the target molecule by a polarization change between the functionalized electrode and the unfunctionalized electrode.
- 21. A method of manufacturing a circuit comprising attaching a first molecule capable of undergoing a hybridization event to a first end of a nanomaterial and hybridizing the first molecule to a second molecule located on a first pad of a die.
- 26. A die comprising a first pad, a second pad and a nanomaterial connecting the first and second pads, wherein the nanomaterial is connected to the first and second pads by a hybridized molecule.
- 28. An electrode having a three dimensional shape of a via.
- 31. A test device comprising (a) a first metal layer comprising a functionalized electrode comprising a probe molecule and (b) a second metal layer comprising a second electrode that can be resistively heated to cause a target molecule to de-hybridize, wherein the test device is to study de-hybridization of the target molecule.
- 41. A device for trapping a target molecule comprising a first electrode, a second electrode and a third electrode, wherein the first, second and third electrodes are independently addressable electrodes, and wherein the second and third electrodes overlap the first electrode and contains a channel above the first electrode to permit the target molecule to be trapped into the channel.
- 51. A method for manufacturing a device for trapping a target molecule, comprising forming a first electrode on a substrate, forming a second electrode on the first electrode, a forming third electrode on the second electrode, and forming a channel in the second and third electrodes, wherein the first, second and third electrodes are independently addressable electrodes and the channel above the first electrode is to permit the target molecule to be trapped into the channel.
Specification