System for Measuring Pulsatile Vascular Resistance
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Abstract
The invention relates to acquiring information concerning the physiological status of the brain by measuring and analysing variations of blood flow velocities and blood pressure within body parts or organs, in particular within the brain. Provided is a system for the analysis of arterial blood flow velocity measurements, comprising means for receiving input signals delivered by an arterial blood flow velocity (FV) sensor and by an arterial blood pressure (BP) sensor, wherein said FV and BP signals are recorded simultaneously and continuously, further comprising means for processing and outputting signals, wherein said processing comprises (i) normalizing said FV and BP signal with the minimal diastolic flow velocity or blood pressure set at 0 and the maximal systolic flow velocity or blood pressure set at 1; (ii) optionally synchronizing the normalized FV and the normalized BP signals at mid-upstroke; (iii) calculating the mean normalized FV and the mean normalized BP per time unit; and (iv) determining the ratio between the mean normalized FV signal and the mean normalized BP signal. Also provided is a method for determining pulsatile vascular resistance, and an apparatus for carrying out such a method.
25 Citations
32 Claims
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1-14. -14. (canceled)
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15. A system for the analysis of arterial blood flow velocity measurements comprising means for receiving input signals delivered by an arterial blood flow velocity (FV) sensor and by an arterial blood pressure (BP) sensor, wherein said FV and BP signals are recorded simultaneously and continuously, further comprising means for processing and outputting signals, wherein said processing comprises:
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synchronization of both signals at start upstroke, a beat-to-beat analysis of the signals, whereby the pulsatile vascular resistance is calculated from the difference in relationship between FV and BP signals during systole compared to diastole. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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26. Method for determining pulsatile vascular resistance (PVR), preferably pulsatile vascular cerebrovascular resistance, said method comprising the steps of:
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recording an arterial blood flow velocity (FV) signal and an arterial blood pressure (BP) signal, wherein said FV and BP signals are recorded simultaneously and continuously;
synchronizing said FV and BP signal at start-upstroke;
optionally averaging said signals to avoid respiratory effects; and
calculating the pulsatile vascular resistance in a beat-to-beat analysis of the signals, from the difference in relationship between FV and BP signals during systole compared to diastole. - View Dependent Claims (27, 28, 29, 30, 31)
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32. Module for calculation of the pulsatile vascular resistance, which is connectable to apparatuses that measure blood flow velocity and blood pressure.
Specification