Microprojection Array Application with Grouped Microprojections for High Drug Loading
First Claim
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1. An apparatus for stratum-corneum piercing drug delivery, comprising:
- a microprojection member having a plurality of stratum-corneum piercing microprojections for piercing stratum-corneum to facilitate drug delivery, wherein at least some of the microprojections are arranged in groups, each group having at least two adjacent microprojections.
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Abstract
A transdermal drug delivery system with microprojections for disrupting a body surface to an individual. At least some of the microprojections form groups in a microprojection array. There are repeated units of such groups in the microprojection array.
58 Citations
41 Claims
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1. An apparatus for stratum-corneum piercing drug delivery, comprising:
- a microprojection member having a plurality of stratum-corneum piercing microprojections for piercing stratum-corneum to facilitate drug delivery, wherein at least some of the microprojections are arranged in groups, each group having at least two adjacent microprojections.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. An apparatus for stratum-corneum piercing drug delivery, comprising:
- a microprojection member having a plurality of stratum corneum piercing microprojections for piercing stratum corneum to facilitate drug delivery, at least some of the microprojections are arranged in groups of at least two adjacent microprojections;
in at least some of the groups the microprojections have shafts of different lengths, a microprojection extending normally from the microprojection member and another microprojection leaning to the shorter microprojection forming a pinnacle; and
in said at least some of the groups a continuous drug coating coats at least a top portion of the microprojections in the group, the drug coating having a meniscus bridging the microprojections in the group.
- a microprojection member having a plurality of stratum corneum piercing microprojections for piercing stratum corneum to facilitate drug delivery, at least some of the microprojections are arranged in groups of at least two adjacent microprojections;
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24. A method for stratum-corneum piercing drug delivery to an individual comprising:
- (a) providing a plurality of stratum corneum piercing microprojections for piercing stratum corneum to facilitate drug delivery, (b) arranging at least some of the microprojections in groups of at least two adjacent microprojections, and (c) piercing the stratum-corneum of said individual with microprojections from the microprojection array.
- View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32)
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33. A method for forming a stratum-corneum piercing drug delivery apparatus, comprising:
- (a) forming a microprojection array, the microprojection array having a plurality of stratum corneum piercing microprojections for piercing stratum corneum to facilitate drug delivery, and (b) arranging at least some of the microprojections in groups of at least two adjacent microprojections.
- View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41)
Specification