Methods and devices to curb appetite and/or to reduce food intake
First Claim
1. A small intestinal insert comprising an elongated member including a proximal end;
- a distal end;
at least one angled portion between the proximal end and the distal end, the angled portion corresponding to at least one angled target site within the small intestine; and
at least a portion of the insert formed of a biodegradable material;
the elongated member configured initially to sit stably within the targeted site, and then, following degradation of the biodegradable material, configured to destabilize such that it becomes unseated from the target site.
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Accused Products
Abstract
The present invention relates to devices and methods of operating the devices that contribute to curbing appetite and/or reducing food intake. In some embodiments, the methods and devices of the present invention include as intestinal/duodenal insert comprising an elongated member with at least one flow reduction element that can cause the stimulation of one or more biological signals of satiety. Some embodiments of the inserted device are anchored at the duodenal site by an anchoring member residing in the stomach, other embodiments of the device are stabilized at a targeted site by appropriate dimensions of length as well as one or more angled portions of the device that correspond to angled portions of the targeted site in the dodenum. Embodiments of the device exert effects by virtue of physical presence, as well as by more active forms of intervention, including release of bioactive materials and electrical stimulation of neurons.
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Citations
85 Claims
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1. A small intestinal insert comprising
an elongated member including a proximal end; -
a distal end;
at least one angled portion between the proximal end and the distal end, the angled portion corresponding to at least one angled target site within the small intestine; and
at least a portion of the insert formed of a biodegradable material;
the elongated member configured initially to sit stably within the targeted site, and then, following degradation of the biodegradable material, configured to destabilize such that it becomes unseated from the target site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A small intestinal insert comprising
an elongated member including a proximal end; -
a distal end;
at least one angled portion between the proximal end and the distal end, the angled portion corresponding to at least one angled target site within the small intestine, and wherein the at least one angled portion of the insert corresponds to at least one angled target site within the small intestine; and
a neurological stimulator, supported by the elongate member. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A small intestinal insert comprising:
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an elongated member including a proximal end;
a distal end;
at least one angled portion between the proximal end and the distal end, the angled portion corresponding to at least one angled target site within the small intestine; and
wherein the at least one angled portion of the insert corresponds to at least one angled target site within the small intestine; and
one or more releasable reservoirs containing one or more bioactive materials, the one or more reservoirs supported by the elongated member; and
an active drug release mechanism supported by the elongated member, the active drug release mechanism and the one or more releasable reservoirs in operable communication with each other. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. A method of generating satiety in a subject comprising:
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positioning an insert in the small intestine, the insert including;
an elongated member including a proximal end;
a distal end;
at least one angled portion between the proximal end and the distal end, the angled portion corresponding to at least one angled target site within the small intestine; and
at least a portion of the insert formed of a biodegradable material;
the elongated member configured initially to sit stably within the targeted site, and then, following degradation of the biodegradable material, configured to destabilize such that it becomes unseated from the target site, and generating one or more signals of satiety due to one or more effects of any of the presence of the insert or an active intervention by the insert. - View Dependent Claims (58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
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73. A method of generating satiety in a subject comprising:
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positioning an insert in the small intestine, the insert including;
an elongated member including a proximal end;
a distal end;
at least one angled portion between the proximal end and the distal end, the angled portion corresponding to at least one angled target site within the small intestine, wherein the at least one angled portion of the insert corresponds to at least one angled target site within the small intestine; and
a neurological stimulator, supported by the elongated member; and
stimulating nerves of the duodenum with the neurological stimulator. - View Dependent Claims (74, 75, 76, 77, 78)
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79. A method of generating satiety in a subject comprising:
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positioning an insert in the small intestine, the insert comprising an elongated member including a proximal end;
a distal end;
at least one angled portion between the proximal end and the distal end, the angled portion corresponding to at least one angled target site within the small intestine; and
wherein the at least one angled portion of the insert corresponds to at least one angled target site within the small intestine; and
one or more releasable reservoirs containing one or more bioactive materials, the one or more reservoirs supported by the elongated member; and
an active drug release mechanism supported by the elongated member, the active drug release mechanism and the one or more releasable reservoirs in operable communication with each other; and
releasing one or more bioactive agents into the duodenum. - View Dependent Claims (80, 81, 82, 83, 84, 85)
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Specification