INJECTABLE COMPOSITION FOR TREATMENT OF SKIN DEFECTS OR DEFORMATIONS

• US 20070298005A1
• Filed: 06/21/2007
• Published: 12/27/2007
• Est. Priority Date: 06/22/2006
• Status: Abandoned Application

• Current Assignee: Marie-Josee Thibault
• Original Assignee: Marie-Josee Thibault
• Inventors: Thibault, Marie-Josee
• Application Number:
  US11/766,629
• Publication Number:
  US 20070298005A1
• Time in Patent Office: Days
• US Class Current: 424/70.31
• CPC Class Codes: A61K 2800/91 Injection
• CPC Class Codes: A61K 31/275 Nitriles; Isonitriles
• CPC Class Codes: A61K 36/47 Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
• CPC Class Codes: A61K 8/02 characterised by special physical form
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Provided are injectable compositions for correction of skin contour defects or deformations. Also provided are methods of use and manufacturing of compositions for correction of skin contour defects or deformations.

Claims

1. A pharmaceutically acceptable, injectable composition for the treatment of skin contour defects or deformations comprising at least one ethoxylated castor oil and a physiologically acceptable solvent.

2. The composition of claim 1, wherein the ethoxylated castor oil comprises a polyoxyethylene glycol group.

3. The composition of claim 1, wherein the ethoxylated castor oil has been obtained by the reaction of castor oil and ethylene oxide in a ratio of between about 1:

30 and about 1;

45.

4. The composition of claim 1, wherein the ethoxylated castor oil is PEG-35 castor oil.

5. The composition of claim 1, comprising from about 0.1% to about 40.0% w/w of the ethoxylated castor oil.

6. The composition of claim 5, comprising about 40% w/w of PEG-35 castor oil.

7. The composition of claim 1, further comprising at least one anesthetic, preservative, tonicity agent, or combinations thereof.

8. The composition of claim 7, wherein the anesthetic is lidocaine.

13. The method of claim 1, wherein the composition comprises from about 0.1% to about 40.0% w/w of the ethoxylated castor oil.

14. The method of claim 13, wherein the composition comprises about 40% w/w PEG-35 castor oil.

9. A method of treating skin contour defects or deformations comprising:

injecting a pharmaceutically acceptable composition comprising at least one ethoxylated castor oil and

a physiologically acceptable solvent to at least one compartment of a patient'"'"'s skin;

wherein the skin surface exhibits at least one contour defect or deformation; and

whereby the skin contour defect or deformation is treated after the injection.

10. The method of claim 9, wherein the ethoxylated castor oil in the composition comprises a polyoxyethylene glycol group.

11. The method of claim 9, wherein the ethoxylated castor oil in the composition has been obtained by the reaction of castor oil and ethylene oxide in a ratio of between about 1:

30 and about 1;

45.

12. The method of claim 9, wherein the ethoxylated castor oil in the composition is PEG-35 castor oil.

15. The method of claim 9, wherein the composition further comprises at least one anesthetic, preservative, tonicity agent, or combinations thereof.

16. The method of claim 15, wherein the anesthetic in the composition is lidocaine.

17. The method of claim 9, wherein the composition is first injected into the reticular dermis, and then injected into the papillary dermis.

18. The method of claim 9, wherein the volume of the composition ranges from about 0.01 to about 60.0 cubic centimeters.

19. The method of claim 18, wherein the volume of the composition ranges from about 5.0 to about 40.0 cubic centimeters.

20. The method of claim 9, wherein the skin contour defect comprises at least one wrinkle, scar, lip thinning, or combinations thereof.

21. A method of manufacturing a pharmaceutically acceptable, injectable composition for the treatment of skin contour defects or deformations comprising:

a. solubilizing at least one ethoxylated castor oil in a physiologically acceptable solvent;

b. sterilizing the solution comprising at least one ethoxylated castor oil; and

c. mixing the solution comprising at least one ethoxylated castor oil.

22. The method of claim 21, further comprising adding at least one anesthetic, preservative, tonicity agent, or combinations thereof after sterilizing the solution.