Control release drug coating for medical devices
First Claim
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1. A coated medical device comprising:
- (a) a medical device body; and
(b) a coating disposed over the medical device body, the coating comprising;
(i) a first layer comprising a first copolymer having a first therapeutic agent therein; and
(ii) a second layer comprising a second copolymer having a second therapeutic agent therein, wherein the second layer is more hydrophilic than the first layer;
wherein the first copolymer and second copolymer are each selected from the group consisting of block copolymers, random copolymers, or alternating copolymers.
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Abstract
A medical device having multiple layers of a drug-loaded coating. At least one of the layers is more hydrophilic than at least another one of the layers. Also provided is a method for controlling the drug release profile from a coated medical device using multiple layers of modified and/or unmodified copolymers and varying the ratio of modified to unmodified copolymers.
18 Citations
20 Claims
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1. A coated medical device comprising:
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(a) a medical device body; and (b) a coating disposed over the medical device body, the coating comprising; (i) a first layer comprising a first copolymer having a first therapeutic agent therein; and (ii) a second layer comprising a second copolymer having a second therapeutic agent therein, wherein the second layer is more hydrophilic than the first layer; wherein the first copolymer and second copolymer are each selected from the group consisting of block copolymers, random copolymers, or alternating copolymers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of controlling the drug release profile from a coated medical device comprising:
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(a) providing a medical device comprising a medical device body; and (b) disposing a coating over the medical device body, the coating comprising first and second layers, each of the first and second layers comprising block copolymers and a therapeutic agent, wherein at least the second layer comprises a modified block copolymer, and wherein the second layer is more hydrophilic than the first layer. - View Dependent Claims (18, 19, 20)
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Specification