Drug for External Use and Adhesive Patch

• US 20070298089A1
• Filed: 11/09/2005
• Published: 12/27/2007
• Est. Priority Date: 11/10/2004
• Status: Abandoned Application

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Saeki, Masakazu, Yoshinaga, Takaaki, Wakamatsu, Masato
• Application Number:
  US11/666,986
• Publication Number:
  US 20070298089A1
• Time in Patent Office: Days
• US Class Current: 424/448
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/196 the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• CPC Class Codes: A61K 31/381 having five-membered rings
• CPC Class Codes: A61K 31/405 Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/42 Oxazoles
• CPC Class Codes: A61K 31/5415 ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
• CPC Class Codes: A61K 31/63 Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
• CPC Class Codes: A61K 33/08 Oxides; Hydroxides
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 47/183 Amino acids, e.g. glycine, EDTA or aspartame
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/7053 obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

An external preparation characterized by containing a pharmacologically active component such as an anti-inflammatory drug, and a lipophilic polyglycerin fatty acid ester.

Claims

1. An external preparation containing:

a pharmacologically active component; and

a lipophilic polyglycerin fatty acid ester.

2. An external preparation according to claim 1,

wherein the HLB value of the polyglycerin fatty acid ester is no greater than 9.

3. An external preparation according to claim 1,

wherein the polyglycerin fatty acid ester is an ester of a polyglycerin with an average polymerization degree of 2 to 14 and a C14 to 24 fatty acid.

4. An external preparation according to claim 1,

wherein the polyglycerin fatty acid ester is an ester of a polyglycerin and a condensation product of hydroxyl group-containing fatty acids.

5. An external preparation according to claim 1,

which contains the polyglycerin fatty acid ester at 0.01 to 10 wt % based on the total weight.

6. An external preparation according to claim 1,

wherein the pharmacologically active component is an anti-inflammatory drug.

7. An external preparation according to claim 6,

wherein the anti-inflammatory drug is at least one selected from the group consisting of non-steroidal anti-inflammatory analgesics, disease modifying antirheumatic drugs and cytokine blockers.

8. An external preparation according to claim 7,

wherein the non-steroidal anti-inflammatory analgesic is at least one selected from the group consisting of indomethacin, ketoprofen, diclofenac, flurbiprofen, felbinac, ibuprofen, suprofen, tiaprofen, loxoprofen, celecoxib, rofecoxib, meloxicam and valdecoxib.

9. An external preparation according to claim 1,

which further contains either or both an edetic acid salt and/or aluminum hydroxide.

10. An external preparation according to claim 1,

which contains substantially no water.

11. An external preparation according to claim 1,

which further contains a base that dissolves or disperses the pharmacologically active component and polyglycerin fatty acid ester.

12. An external preparation according to claim 11,

wherein the base contains at least one substance selected from the group consisting of natural rubber, synthetic isoprene rubber, polyisobutylene, polyvinyl ether, polyurethane, polyisoprene, polybutadiene, styrene-butadiene copolymer, styrene-isoprene copolymer, styrene-isoprene-styrene block copolymer, acrylic pressure-sensitive adhesives and silicone-based pressure-sensitive adhesives.

13. An adhesive patch comprising:

a pressure-sensitive adhesive layer including an external preparation according to claim 11;

and

a backing bearing the pressure-sensitive adhesive layer.