DETECTION OF MYOCARDIAL ISCHEMIA FROM THE TIME SEQUENCE OF IMPLANTED SENSOR MEASUREMENTS

• US 20070299356A1
• Filed: 06/27/2006
• Published: 12/27/2007
• Est. Priority Date: 06/27/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Wariar, Ramesh, Kadhiresan, Veerichetty, Fogoros, Richard
• Granted Patent: US 8,000,780 B2
• Time in Patent Office: Days
• US Class Current: 600/513
• CPC Class Codes: A61B 5/02 Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 7/04 Electric stethoscopes microphones, acoustic transducers therefor H04R
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

A system including a plurality of implantable sensors, a processor, and a response circuit. Each sensor produces an electrical sensor signal related to physiologic cardiovascular events of a subject. The processor includes an event sequence detector to permit real-time detection of a time-wise sequential cascade of physiologic cardiovascular events related to myocardial ischemia of a subject and a decision module. The time-wise cascade includes at least first, second, and third physiologic cardiovascular events. The decision module declares whether an ischemic event occurred using at least one rule applied to a temporal relationship of the first, second, and third physiologic cardiovascular events. The response circuit provides a specified response if the ischemic event is declared.

Claims

1. A system comprising:

a plurality of sensors, each sensor operable to produce an electrical sensor signal related to physiologic cardiovascular events of a subject, and wherein at least one of the sensors is implantable; and

a processor in communication with the implantable sensors, wherein the processor comprises;

an event sequence detector to permit real-time detection of a time-wise sequential cascade of physiologic cardiovascular events related to myocardial ischemia of the subject, wherein the time-wise cascade includes at least first, second, and third physiologic cardiovascular events; and

a decision module to declare whether an ischemic event occurred using at least one rule applied to a temporal relationship of the first, second, and third physiologic cardiovascular events; and

a response circuit, coupled to the decision module, the response circuit operable to provide a specified response if the ischemic event is declared.

2. The system of claim 1, wherein the processor further includes:

a detection module in communication with at least one of the sensors, wherein the detection module is adapted to;

declare the first physiologic cardiovascular event according to a first detection criterion applied to a first sensor signal;

declare the second physiologic cardiovascular event according to a second detection criterion applied to a second sensor signal; and

declare the third physiologic cardiovascular event according to a third detection criterion applied to a third sensor signal; and

wherein the response circuit, if at least one of the second and third physiologic events is declared without the first physiologic event being declared, modifies the first detection criterion and examines the first sensor signal during a time period before the second physiologic cardiovascular event to determine if the first physiologic cardiovascular event was undetected, and determines the specified response to be delivered.

3. The system of claim 2, wherein if the response circuit determines that the first event was undetected, the response circuit specifies the response such that the response comprises:

(1) immediately delivering a therapy, (2) communicating an alarm based on the difference between the first sensor signal and the first specified threshold, or (3) both immediately delivering a therapy and communicating an alarm based on the difference between the first sensor signal and the first specified threshold.

4. The system of claim 1, wherein the processor further includes:

a detection module in communication with at least one of the sensors, wherein the detection module is adapted to;

declare the first physiologic cardiovascular event according to a first detection criterion applied to a first sensor signal;

declare the second physiologic cardiovascular event according to a second detection criterion applied to a second sensor signal; and

declare the third physiologic cardiovascular event according to a third detection criterion applied to a third sensor signal; and

a timing circuit, in communication with the detection module, the timing circuit initiating a timing window triggered by the first physiologic cardiovascular event; and

a response inhibition circuit, coupled to the timing circuit, the decision module, and the response circuit, the response inhibition circuit inhibiting the specified response upon at least one of the second and third physiologic cardiovascular events being absent during the timing window.

5. The system of claim 4, wherein the response circuit provides a response selected from an alarm and a therapy.

6. The system of claim 1, wherein the processor further includes:

a detection module in communication with at least one of the sensors, wherein the detection module is adapted to;

declare the first physiologic cardiovascular event according to a first detection criterion applied to a first sensor signal;

declare the second physiologic cardiovascular event according to a second detection criterion applied to a second sensor signal; and

declare the third physiologic cardiovascular event according to a third detection criterion applied to a third sensor signal; and

a timing circuit, in communication with the detection module, the timing circuit initiating a timing window triggered by the first physiologic cardiovascular event; and

wherein the response circuit triggers the specified response upon the second and third physiologic cardiovascular events occurring during the timing window.

7. The system of claim 6, comprising means, coupled to the response circuit, for providing an alarm upon detecting the second and third physiologic cardiovascular event.

8. The system of claim 1, wherein one or more of the sensors are selected from the group consisting of:

a) a heart sound sensor;

b) a three-dimensional (3D) heart sound sensor;

c) a transthoracic impedance measurement circuit;

d) an intracardiac impedance measurement circuit;

e) an electrical cardiac signal sensing circuit;

f) a heart rate sensor;

g) a heart rate variability sensor;

h) a cardiac pressure sensor; and

i) a patient activity sensor.

9. The system of claim 1, wherein the first, second, and third physiologic cardiovascular events include events selected from the group consisting of:

a) left ventricle wall motion abnormality;

b) an increase in heart rate;

c) a decrease in heart relaxation interval;

d) increased ventricle filling pressure; and

e) a decrease in heart contractility.

10. The system of claim 1, wherein the processor and the response circuit are included in an external device and the plurality of implantable sensors are included in an implantable medical device (IMD), and wherein the IMD further includes:

a controller circuit, coupled to the implantable sensors and the response circuit; and

a communication circuit, coupled to the controller circuit, wherein the IMD is operable to communicate information obtained from the sensors to the external device; and

wherein the system further comprises a memory in communication with the external device, the memory to store data related to physiologic cardiovascular events of the subject, and wherein the decision module is configured to declare whether an ischemic event occurred using at least one rule applied to both the temporal relationship of the first, second, and third physiologic cardiovascular events and to the stored data.

11. The system of claim 10, wherein the external device includes a remote server in communication with the IMD over a communications or computer network.

12. The system of claim 10, wherein the external device includes an IMD programmer.

13. The system of claim 1, wherein the plurality of implantable sensors and the processor are included in an implantable medical device (IMD), wherein the IMD further includes a communication circuit coupled to the processor, and wherein the system further comprises an external device, wherein the IMD is operable to communicate information obtained from the implantable sensors to the external device.

14. The system of claim 13, wherein the external device includes:

a memory to store data related to physiologic cardiovascular events of the subject; and

a second processor including a second decision module in communication with the memory, wherein the second decision module is configured to declare whether an ischemic event occurred using at least one rule applied to both the temporal relationship of the first, second, and third physiologic cardiovascular events and to the stored data.

15. The system of claim 13, wherein the external device includes an IMD programmer.

16. The system of claim 15, wherein the external device includes a user interface to receive a user input and the decision module is operable to declare whether an ischemic event occurred using at least one rule applied to a temporal relationship of the first, second, and third physiologic cardiovascular events and the user input.

17. The system of claim 10, wherein the system further includes an external electrocardiograph (ECG) circuit operable to communicate one or more ECG signals to the external device, and wherein the first, second, and third physiologic cardiovascular events include events indicated by the one or more ECG signals.

18. The system of claim 1, wherein the decision module comprises weights assigned to the first, second, and third physiologic cardiovascular events, the weights indicating a likelihood that the corresponding event indicates ischemia.

19. The system of claim 1, wherein the processor further includes:

a detection module in communication with at least one of the sensors, wherein the detection module is adapted to;

declare the first physiologic cardiovascular event according to a first detection criterion applied to a first sensor signal;

declare the second physiologic cardiovascular event according to a second detection criterion applied to a second sensor signal; and

declare the third physiologic cardiovascular event according to a third detection criterion applied to a third sensor signal; and

wherein the response circuit, if at least one of the second and third physiologic events is declared without the first physiologic event being declared, reduces a detection threshold of one or more of the sensor signals and determines the specified response to be delivered if the ischemic event is subsequently declared.

20. A method comprising:

sensing at least first, second and third sensor signals, each sensor signal including physiologic cardiovascular information and at least one sensor signal provided by an implantable sensor;

detecting at least first, second, and third physiologic cardiovascular events from the first, second, and third implantable sensor signals; and

declaring whether an ischemic event occurred using at least one rule applied to a temporal relationship of the first, second, and third physiologic cardiovascular events.

21. The method of claim 20, wherein detecting the first physiologic cardiovascular event includes detecting a first sensor signal reaching a first specified sensor threshold value, and wherein the method further includes:

timing a duration from the detection of the first physiologic cardiovascular event to a scheduled response; and

altering the scheduled response if at least one of the second and third physiologic cardiovascular events is detected during the timing of the duration.

22. The method of claim 21, wherein altering the scheduled response includes immediately delivering the response upon detecting at least one of the second and third physiologic cardiovascular events, wherein the response includes at least one of an alarm and a delivery of an electrical energy.

23. The method of claim 22, comprising delivering the response after timing the duration, wherein the response includes at least one of an alarm and a delivery of an electrical energy.

24. The method of claim 21, including inhibiting the scheduled response if at least one of the second and third physiologic cardiovascular events is absent during the timing of the duration.

25. The method of claim 20, comprising:

detecting a difference between a measurement based on a first sensor signal and a specified first detection criterion applied to the first sensor signal;

declaring whether the second physiologic cardiovascular event occurred using a second detection criterion applied to the second sensor signal;

declaring whether the third physiologic cardiovascular event occurred using a third detection criterion applied to the third sensor signal; and

if at least one of the second and third events is declared, then using the difference between the measurement based on the first sensor signal and the specified first detection criterion, during a specified time duration before the declaration of the second or third event, to determine a response to the ischemic event.

26. The method of claim 25, comprising delivering the response, based on the difference between the measurement based on the first sensor signal and the specified first detection criterion, in response to the declared second or third event, wherein the delivered response includes at least one of an alarm and an electrical energy delivery.

27. The method of claim 20, including assigning a weight to one or more of the first, second, and third events according to a likelihood that the one of the first, second, and third events indicates ischemia.

28. The method of claim 20, including receiving an indication of subject discomfort related to ischemia, and declaring whether an ischemic event occurred at least in part by using the indication.

29. The method of claim 20, including detecting at least one of the first, second, and third physiologic cardiovascular events from an external electrocardiograph (ECG) signal.

30. The method of claim 20, comprising:

detecting a difference between a measurement based on a first sensor signal and a specified first detection criterion applied to the first sensor signal;

declaring whether the second physiologic cardiovascular event occurred using a second detection criterion applied to the second sensor signal;

declaring whether the third physiologic cardiovascular event occurred using a third detection criterion applied to the third sensor signal; and

if at least one of the second and third events is declared, then reducing a detection threshold for at least the first sensor signal.