DEVICE FOR THE CONTROLLED EXPOSURE OF RESERVOIR-BASED SENSORS

• US 20070299385A1
• Filed: 09/06/2007
• Published: 12/27/2007
• Est. Priority Date: 03/02/2000
• Status: Active Grant

• Current Assignee: Microchips Biotech, Inc. (Keratin Biosciences, Inc.)
• Original Assignee: MicroCHIPS Inc.
• Inventors: Langer, Robert, Santini, John, Sheppard, Norman, Young, Chung
• Granted Patent: US 7,410,616 B2
• Time in Patent Office: Days
• US Class Current: 604/19
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61K 47/6957 the form being a device or a kit, e.g. stents or microdevices
• CPC Class Codes: A61K 49/0002 General or multifunctional contrast agents, e.g. chelated agents
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: B01J 19/0093 Microreactors, e.g. miniaturised or microfabricated reactors laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027
• CPC Class Codes: B01J 2219/00317 Microwell devices, i.e. having large numbers of wells
• CPC Class Codes: B01J 2219/00351 Means for dispensing and evacuation of reagents
• CPC Class Codes: B01J 2219/00783 Laminate assemblies, i.e. the reactor comprising a stack of plates
• CPC Class Codes: B01J 2219/00819 Materials of construction
• CPC Class Codes: B01J 2219/00822 Metal
• CPC Class Codes: B01J 2219/00824 Ceramic
• CPC Class Codes: B01J 2219/00828 Silicon wafers or plates
• CPC Class Codes: B01J 2219/00831 Glass
• CPC Class Codes: B01J 2219/00833 : Plastic
• CPC Class Codes: B01J 2219/00835 : Comprising catalytically active material
• CPC Class Codes: B01J 2219/00844 : Comprising porous material
• CPC Class Codes: B01J 2219/00853 : Employing electrode arrangements
• CPC Class Codes: B01J 2219/00873 : Heat exchange
• CPC Class Codes: B01J 2219/00889 : Mixing micromixers B01F33/30
• CPC Class Codes: B01J 2219/00907 : using membranes
• CPC Class Codes: B01J 2219/00925 : Irradiation
• CPC Class Codes: B01J 2219/00952 : Sensing operations
• CPC Class Codes: B01J 2219/00957 : Compositions or concentrations
• CPC Class Codes: B01J 2219/00966 : pH
• CPC Class Codes: B01J 2219/0097 : Optical sensors
• CPC Class Codes: B01J 2219/00984 : Residence time
• CPC Class Codes: B01J 2219/00986 : Microprocessor
• CPC Class Codes: B01L 2200/12 : Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/023 : Sending and receiving of information, e.g. using bluetooth
• CPC Class Codes: B01L 2300/049 : Valves integrated in closure
• CPC Class Codes: B01L 2300/0627 : Sensor or part of a sensor is integrated
• CPC Class Codes: B01L 2300/0654 : Lenses; Optical fibres
• CPC Class Codes: B01L 2300/0819 : Microarrays; Biochips
• CPC Class Codes: B01L 2400/0677 : phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
• CPC Class Codes: B01L 3/50853 : with covers or lids
• CPC Class Codes: C40B 60/14 : for creating libraries
• CPC Class Codes: G01N 2035/00158 : Elements containing microarrays, i.e. "biochip"
• CPC Class Codes: G01N 2035/00247 : Microvalves
• CPC Class Codes: Y10T 29/49007 : Indicating transducer
• CPC Class Codes: Y10T 29/49117 : Conductor or circuit manufacturing
• CPC Class Codes: Y10T 436/25 : including sample preparation

Abstract

Devices are provided for the controlled exposure of a sensor or sensor component. The device may include a substrate; at least one reservoir provided in the substrate; at least one sensor or sensor component located in the at least one reservoir; at least one reservoir cap closing an opening in the at least one reservoir to isolate the sensor or sensor component from a selected environmental component outside of the at least one reservoir; at least one intermediate barrier layer disposed in the at least one reservoir between the reservoir cap and the sensor or sensor component; and means for disintegrating the reservoir cap to expose the sensor or sensor component to the selected environmental component.

Claims

1. A device for the controlled exposure of a sensor or sensor component, comprising:

a substrate;

at least one reservoir provided in the substrate;

at least one sensor or sensor component located in the at least one reservoir;

at least one reservoir cap closing an opening in the at least one reservoir to isolate the sensor or sensor component from a selected environmental component outside of the at least one reservoir;

at least one intermediate barrier layer disposed in the at least one reservoir between the reservoir cap and the sensor or sensor component; and

means for disintegrating the reservoir cap to expose the sensor or sensor component to the selected environmental component.

2. The device of claim 1, wherein the intermediate barrier layer comprises a semi-permeable membrane, which is permeable to the selected environmental component.

3. The device of claim 1, wherein the sensor or sensor component comprises at least one electrode.

4. The device of claim 1, wherein the intermediate barrier layer comprises a soluble or biodegradable polymer.

5. The device of claim 1, wherein the selected environmental component comprises glucose.

6. The device of claim 5, wherein the sensor or sensor component comprises or is part of a glucose sensor.

7. The device of claim 1, having a plurality of reservoirs, a plurality of sensors or sensor components, and a plurality of reservoir caps.

8. The device of claim 1, wherein the substrate comprises a first substrate portion and a second substrate portion bonded together.

9. The device of claim 8, wherein the first substrate portion comprises the at least one reservoir and the second substrate portion has the at least one sensor thereon, which sensor is aligned with the at least one reservoir of the first substrate portion and sealed therein by the bonding together of the first and second substrate portions.

10. The device of claim 9, further comprising at least one drug delivery unit which comprises at least one therapeutic agent for delivery to a patient and which is in communication with the at least one sensor or sensor component.

11. The device of claim 1, wherein the at least one intermediate barrier layer comprises a nanoporous or microporous silicon membrane.

12. The device of claim 1, wherein the sensor detects carbon dioxide, carbon monoxide, ammonia, dioxygen, ethanol, ionized calcium, sodium ion, potassium ion, lithium ion, hydrogen ion, chloride ion, magnesium ion, ammonium ion, hydrogen peroxide, ascorbic acid, cholesterol, uric acid, esterified cholesterol, urea, creatinine, creatine, triglycerides, lactate dehydrogenase, creatine kinase, alkaline phosphatase, creatine kinase-MB, alanine transaminase, aspartate transaminase, bilirubin, amylase, or lipase.

13. The device of claim 1, wherein the sensor comprises an electrochemical transducer, which is amperometric, potentiometric, or conductimetric.

14. The device of claim 1, wherein the sensor comprises at least one electrode, an adhesion promoter layer on the at least one electrode, and a bioactive layer that is immobilized on the adhesion promoter layer.

15. The device of claim 14, wherein the bioactive layer comprises an enzyme selected from the group consisting of glucose oxidase, glucose dehydrogenase, NADH oxidase, uricase, urease, creatininase, sarcosine oxidase, creatinase, creatine kinase, creatine amidohydrolase, cholesterol esterase, cholesterol oxidase, glycerol kinase, hexokinase, glycerol-3-phosphate oxidase, lactate dehydrogenase, alkaline phosphatase, alanine transaminase, aspartate transaminase, amylase, lipase, esterase, gamma-glutamyl transpeptidase, L-glutamate oxidase, pyruvate oxidase, diaphorase, bilirubin oxidase, and mixtures thereof

16. A device for the controlled exposure of a sensor or sensor component, comprising:

a substrate;

at least one reservoir provided in the substrate;

at least one sensor or sensor component located in the at least one reservoir;

at least one reservoir cap closing an opening in the at least one reservoir to isolate the sensor or sensor component from the environment outside of the at least one reservoir, the reservoir cap comprising a metal film;

at least one intermediate barrier layer disposed in the at least one reservoir between the reservoir cap and the sensor or sensor component; and

a power source and electrical circuitry for disintegrating the reservoir cap to expose the sensor or sensor component to the environment outside of the reservoir.

17. The device of claim 16, having a plurality of reservoirs, a plurality of sensors or sensor components disposed in the plurality of reservoirs, and a plurality of discrete reservoir caps.

18. The device of claim 16, wherein the substrate comprises a first substrate portion and a second substrate portion bonded together, the first substrate portion comprising the at least one reservoir and the second substrate portion having thereon the at least one sensor or sensor component, and the sensor or sensor component being aligned with the at least one reservoir of the first substrate portion and sealed therein by the bonding together of the first and second substrate portions.

19. The device of claim 16, wherein the sensor or sensor component comprises or is part of a sensor for detecting glucose, carbon dioxide, carbon monoxide, ammonia, dioxygen, ethanol, ionized calcium, sodium ion, potassium ion, lithium ion, hydrogen ion, chloride ion, magnesium ion, ammonium ion, hydrogen peroxide, ascorbic acid, glucose, cholesterol, uric acid, esterified cholesterol, urea, creatinine, creatine, triglycerides, lactate dehydrogenase, creatine kinase, alkaline phosphatase, creatine kinase-MB, alanine transaminase, aspartate transaminase, bilirubin, amylase, or lipase.