MICROPROJECTION ARRAY APPLICATION WITH MULTILAYERED MICROPROJECTION MEMBER FOR HIGH DRUG LOADING
First Claim
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1. An apparatus for stratum-corneum piercing drug delivery, comprising:
- a microprojection member having a plurality of stratum corneum piercing microprojections for piercing stratum corneum to facilitate drug delivery, the microprojection member having a multilayered base member supporting microprojections, the multilayered base member having at least a first base layer and a second base layer, the first base layer supporting a first plurality of microprojections, the second base layer supporting a second plurality of microprojections, wherein the first plurality of microprojections and the second plurality of microprojections form a microprojection array for piercing the stratum corneum.
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Abstract
A transdermal drug delivery system with microprojections for disrupting a body surface to an individual. At least some of the microprojections arise from a first microprojection layer and at least some of the microprojections arise from a second microprojection layer. The first and second microprojection layers are stacked together.
85 Citations
39 Claims
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1. An apparatus for stratum-corneum piercing drug delivery, comprising:
- a microprojection member having a plurality of stratum corneum piercing microprojections for piercing stratum corneum to facilitate drug delivery, the microprojection member having a multilayered base member supporting microprojections, the multilayered base member having at least a first base layer and a second base layer, the first base layer supporting a first plurality of microprojections, the second base layer supporting a second plurality of microprojections, wherein the first plurality of microprojections and the second plurality of microprojections form a microprojection array for piercing the stratum corneum.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. An apparatus for stratum-corneum piercing drug delivery, comprising:
- a microprojection member having a plurality of stratum corneum piercing microprojections for piercing stratum corneum to facilitate drug delivery, the microprojection member having a multilayered base member supporting microprojections, the multilayered base member having at least a first base layer and a second base layer, the first base layer of the same continuous material with and integrally supporting a first plurality of microprojections, the second base layer of the same continuous material with and integrally supporting a second plurality of microprojections, the first plurality of microprojections neighboring to the second plurality of microprojections forming groups of the two pluralities of microprojections in a microprojection array for piercing the stratum corneum, a drug coating coats at least portion of the microprojection member.
- View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method for stratum-corneum piercing drug delivery to an individual comprising:
- (1) providing a microprojection member having a multilayered base member supporting microprojections, the base member having at least a first base layer and a second base layer, the first base layer supporting a first plurality of microprojections, the second base layer supporting a second plurality of microprojections, the first plurality of microprojections and the second plurality of microprojections forming a microprojection array for piercing the stratum corneum, and (2) piercing the stratum corneum of said individual with the microprojection array.
- View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for forming a stratum-corneum piercing drug delivery apparatus, comprising:
- forming a microprojection member having a microprojection array, the microprojection member having a multilayered base member supporting microprojections, the base member having at least a first base layer and a second base layer, the first base layer supporting a first plurality of microprojections, the second base layer supporting a second plurality of microprojections, the first plurality of microprojections and the second plurality of microprojections forming a microprojection array for piercing the stratum corneum.
- View Dependent Claims (33, 34, 35, 36, 37, 38, 39)
Specification