Secure and Efficacious Therapy Delivery for a Pacing Engine
First Claim
1. A method of safely delivering neurological therapy to an innervated myocardial substrate of a patient to improve cardiac performance via the innervated myocardial substrate of the ventricle, comprising the step of:
- delivering electrical stimulation to at least one ventricular chamber of a heart during a refractory period of said chamber wherein said electrical stimulation impinges upon nerve fibers embedded in the myocardial substrate of the chamber and fails to evoke a depolarization response from myocytes present in the myocardial substrate.
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Abstract
The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
87 Citations
20 Claims
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1. A method of safely delivering neurological therapy to an innervated myocardial substrate of a patient to improve cardiac performance via the innervated myocardial substrate of the ventricle, comprising the step of:
delivering electrical stimulation to at least one ventricular chamber of a heart during a refractory period of said chamber wherein said electrical stimulation impinges upon nerve fibers embedded in the myocardial substrate of the chamber and fails to evoke a depolarization response from myocytes present in the myocardial substrate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method of therapy delivery involving stimulation of a portion of a sympathetic nervous system of a patient for enhanced cardiac function, without stimulating the cardiac tissue sufficiently to evoke a depolarization of said cardiac tissue, comprising the step of:
delivering non-excitatory electrical stimulation to at least a portion of a sympathetic nerve disposed in at least a one of the following regions;
a neck region, a chest region, a mediastimum region, a heart region of a patient so that said heart experiences improved mechanical function due at least in part to release of catecholamine substances.- View Dependent Claims (14, 15, 16, 17)
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18. A method of safely applying RPS stimulation pulse therapy to a chamber of a heart, comprising the steps of:
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confirming that no arrhythmia is occurring for a predetermined number of cardiac cycles of a heart;
delivering a RPS stimulation therapy to a chamber of the heart; and
ceasing delivery of said RPS therapy upon detection of an arrhythmia. - View Dependent Claims (19, 20)
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Specification