Rapid analyte measurement assay
First Claim
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1. A method of measuring the concentration of a target analyte within a biological sample, the method comprising:
- applying the biological sample to an electrochemical cell having a redox reagent system comprising a target analyte-dependent redox couple;
applying a square wave excitation voltage across the electrochemical cell; and
measuring a response current of the electrochemical cell, wherein the response current is representative of the concentration of the target analyte within the biological sample.
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Abstract
The present the invention provides methods, devices and systems for rapidly measuring analytes within a biological sample.
58 Citations
21 Claims
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1. A method of measuring the concentration of a target analyte within a biological sample, the method comprising:
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applying the biological sample to an electrochemical cell having a redox reagent system comprising a target analyte-dependent redox couple; applying a square wave excitation voltage across the electrochemical cell; and measuring a response current of the electrochemical cell, wherein the response current is representative of the concentration of the target analyte within the biological sample. - View Dependent Claims (2, 3, 4, 5)
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6. A method of measuring the concentration of a target analyte within a biological sample, the method comprising:
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applying the biological sample to an electrochemical cell having a redox reagent system comprising a first redox couple and at least one secondary redox couple, wherein the first redox couple is selected to mediate the target analyte and the at least one secondary redox couple is selected so as not to interfere with the target analyte mediation; applying a square wave excitation voltage across the electrochemical cell; measuring a response current of the electrochemical cell, wherein the response current has a primary peak associated with mediation of the target analyte and one or more secondary peaks associated with mediation of at least one non-interfering secondary redox couple; and determining the concentration of the target analyte within the biological sample based on the primary and secondary current peaks. - View Dependent Claims (7, 8, 9, 10, 11)
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12. A device comprising:
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a test strip comprising an electrochemical cell having a redox reagent system comprising a target analyte-dependent redox couple; and a meter configured for applying a square wave excitation voltage across the electrochemical cell, wherein the test strip is configured for electrical engagement with the meter. - View Dependent Claims (13, 14, 15, 16)
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17. A system comprising:
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an electrochemical cell having a redox reagent system comprising a target analyte-dependent redox couple; and a meter configured for applying a square wave excitation voltage across the electrochemical cell, wherein the meter is in electrical communication with the electrochemical cell. - View Dependent Claims (18, 19, 20, 21)
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Specification