Hemodialysis methods and apparatus

• US 20080000835A1
• Filed: 05/17/2006
• Published: 01/03/2008
• Est. Priority Date: 05/17/2005
• Status: Abandoned Application

• Current Assignee: Fresenius Medical Care Holdings Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius Medical Care North America (Fresenius SE & Co. KGaA)
• Inventors: Rogers, Brooks
• Application Number:
  US11/436,891
• Publication Number:
  US 20080000835A1
• Time in Patent Office: Days
• US Class Current: 210/647
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/10 Carbonates; Bicarbonates
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61M 1/1656 Apparatus for preparing dialysates
• CPC Class Codes: A61M 1/1666 by dissolving solids

Abstract

Various methods and apparatus are provided for the administration, control, and display of dialysate constituents, particularly, for example, the acid and bicarbonate constituents, in order to achieve more physiologically desirable proportions of sodium and total base buffer and, more generally, more physiologically desirable dialysate.

Claims

1. A method for producing dialysate, comprising:

(a) determining an amount of bicarbonate present in a bicarbonate dialysate constituent prescribed for administration to a patient and likely to become available bicarbonate in a dialysate produced therefrom;

(b) determining an amount of acetate present in an acid dialysate constituent prescribed for administration to the patient and likely to become available bicarbonate in a dialysate produced therefrom as a result of metabolism of said acetate; and

(c) combining the acid dialysate constituent with the bicarbonate dialysate constituent in such proportion that a total of the amounts determined in (a) and (b) substantially match a total amount of total base buffer desired for administration to the patient.

2. The method of claim 1, further comprising determining an amount of bicarbonate present in the bicarbonate dialysate constituent dissociable in an aqueous solution.

3. The method of claim 1, further comprising determining an amount of acetate present in the acid dialysate constituent dissociable in an aqueous solution.

4. The method of claim 1, further comprising combining the acid dialysate constituent with the bicarbonate dialysate constituent in such a proportion that a total amount of available sodium matches a total amount of sodium desired for administration to the patient.

5. The method of claim 1, further comprising combining an aqueous dialysate constituent with the acid dialysate constituent and with the bicarbonate dialysate constituent in such proportion as to produce a dialysate of desired ionic concentration.

6. The method of claim 1, further comprising calculating a resultant concentration of auxiliary components.

7. A method of hemodialysis, comprising:

administering to a patient a dialysate produced through a process of;

a) determining an amount of bicarbonate present in a bicarbonate dialysate constituent prescribed for administration to the patient and likely to become available bicarbonate in a dialysate produced therefrom;

b) determining an amount of acetate present in an acid dialysate constituent prescribed for administration to the patient and likely to become available bicarbonate in a dialysate produced therefrom as a result of metabolism of said acetate;

c) determining an amount of sodium present in an acid dialysate constituent prescribed for administration to the patient and likely to become available sodium in a dialysate produced therefrom;

d) determining an amount of sodium present in a bicarbonate dialysate constituent prescribed for administration to the patient and likely to become available sodium in a dialysate produced therefrom; and

e) combining the acid dialysate constituent with the bicarbonate dialysate constituent in such proportion that (i) a total of the amounts determined in (a) and (b) substantially matches a total amount of total base buffer desired for administration to the patient, and (ii) a total of the amounts determined in (c) and (d) substantially matches a total amount of sodium desired for administration to the patient.

8. The method of claim 7, in which step (e) further comprises combining an aqueous dialysate constituent with the acid dialysate constituent and with the bicarbonate dialysate constituent in such a proportion as to produce a dialysate of desired ionic concentration.

9. The method of claim 7, further comprising determining an amount of at least one of bicarbonate present in the bicarbonate dialysate constituent and acetate present in the acid dialysate constituent dissociable in an aqueous solution.

11. The method of claim 7, further comprising combining the acid dialysate constituent with the bicarbonate dialysate constituent in such proportion that a total amount of available sodium matches a total amount of sodium desired for administration to the patient.

12. The method of claim 7, further comprising combining an aqueous dialysate constituent with the acid dialysate constituent and with the bicarbonate dialysate constituent in such proportion as to produce a dialysate of desired ionic concentration.

13. The method of claim 7, further comprising calculating and determining a resultant concentration of auxiliary components.

10. (canceled)

14. A method for dialysate administration, comprising:

(a) inputting a value representing a total amount of sodium desired for administration to a patient; and

(b) inputting a value representing a total amount of bicarbonate desired for administration to the patient.

15. The method of claim 14, further comprising (c) inputting a value representing a total amount of acetate in an acid dialysate constituent.

16. The method of claim 14, further comprising:

(d) determining an amount of bicarbonate present in a bicarbonate dialysate constituent prescribed for administration to the patient and likely to become available bicarbonate in a dialysate produced therefrom;

(e) determining an amount of acetate present in an acid dialysate constituent prescribed for administration to the patient and likely to become available bicarbonate as a result of metabolism of the acetate in a dialysate produced therefrom;

(f) determining a proportion of acid dialysate constituent to bicarbonate dialysate constituent, the combination of which, in view of the amounts determined in (a) and (b), substantially match the total amount of base buffer desired for administration to the patient; and

(g) any of displaying a result of the determination in step (f) and administering a dialysate produced from such proportions.

17. The method of claim 14, further comprising calculating and determining a resultant concentration of auxiliary components.

20. The method of claim 14, further comprising:

(d) determining an amount of sodium present in a bicarbonate dialysate constituent prescribed for administration to the patient and likely to become overall available sodium in a dialysate produced therefrom;

(e) determining an amount of sodium present in an acid dialysate constituent prescribed for administration to the patient and likely to become available sodium in a dialysate produced therefrom;

(f) determining a proportion of acid dialysate constituent to bicarbonate dialysate constituent, the combination of which, in view of the amounts determined in (a) and (b), substantially match the total amount of dialysate desired for administration to the patient; and

(g) any of displaying a result of the determination in step (f) and administering a dialysate produced from such proportions.

18-19. -19. (canceled)

21. (canceled)

22. Apparatus for hemodialysis comprising

A. an interface that accepts values representing one or more of (a) a total amount of sodium desired for administration to a patient, and (b) a total amount of buffer desired for administration to the patient,

B. a processor that determines

(i) an amount of bicarbonate present in a bicarbonate dialysate constituent prescribed for administration to a patient and likely to become available bicarbonate in a dialysate produced therefrom;

(ii) an amount of acetate present in an acid dialysate constituent prescribed for administration to the patient and likely to become available bicarbonate in a dialysate produced therefrom as a result of metabolism of said acetate by the patient;

C. the apparatus effecting delivery to a patient of a combination the acid dialysate constituent with the bicarbonate dialysate constituent in such proportion that a total of the amounts determined by the processor in B(i) and B(ii) substantially match a total amount of total base buffer desired for administration to the patient.

23. The apparatus of claim 22, wherein the interface displays any of an amount determined by the processor in B(i), an amount determined by the processor in B(ii), and the proportion of acid dialysate constituent to bicarbonate dialysate constituent delivered to the patient.

24. The apparatus of claim 22, wherein

D. the processor additionally determines

(i) an amount of sodium present in an acid dialysate constituent prescribed for administration to the patient and likely to become available sodium in a dialysate produced therefrom,

(ii) an amount of sodium present in a bicarbonate dialysate constituent prescribed for administration to the patient and likely to become available sodium in a dialysate produced therefrom.

25. The apparatus of claim 24, wherein the apparatus effects delivery to a patient of a combination the acid dialysate constituent with the bicarbonate dialysate constituent in such proportion that a total of the amounts determined by the processor in B(i) and B(ii) substantially match a total amount of total base buffer desired for administration to the patient, and such that a total of the amounts determined in D(i) and D(ii) substantially matches a total amount of sodium desired for administration to the patient.

27. The apparatus of claim 22, wherein the processor determines an amount of at least one of bicarbonate present in the bicarbonate dialysate constituent and acetate present in the acid dialysate constituent dissociable in an aqueous solution.

28. The apparatus of claim 22 which effects combination of the acid dialysate constituent with the bicarbonate dialysate constituent in such a proportion that a total amount of available sodium matches a total amount of sodium desired for administration to the patient.

29. The apparatus of claim 22 which effects combination of an aqueous dialysate constituent with the acid dialysate constituent and with the bicarbonate dialysate constituent in such proportion as to produce a dialysate of desired ionic concentration.

30. The apparatus of claim 25, wherein the interface displays any one of an amount determined by the processor in B(i), an amount determined by the processor in B(ii), an amount determined by the processor in D(i), an amount determined by the processor in D(ii), and the proportion of acid dialysate constituent to bicarbonate dialysate constituent delivered to the patient.

26. (canceled)