GRP78 targeting peptides and methods employing same
3 Assignments
0 Petitions
Accused Products
Abstract
The compositions and methods include targeting peptides selective for tissue selective binding, particularly prostate and/or bone cancer, or adipose tissue. The methods may comprise targeting peptides that bind, for example, cell surface GRP78, IL-11Rα in blood vessels of bone, or prohibitin of adipose vascular tissue. These peptides may be used to induce targeted apoptosis in the presence or absence of at least one pro-apoptotic peptide. Antibodies against such targeting peptides, the targeting peptides, or their mimeotopes may be used for detection, diagnosis and/or staging of a condition, such as prostate cancer or metastatic prostate cancer.
75 Citations
68 Claims
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1-44. -44. (canceled)
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45. An isolated peptide that selectively binds glucose regulated protein 78 (GRP78), wherein the peptide comprises WIFPWIQL (SEQ ID NO:
- 6) or WDLAWMFRLPVG (SEQ ID NO;
7). - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
- 6) or WDLAWMFRLPVG (SEQ ID NO;
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66. An isolated peptide that selectively binds GRP78, identified by a process comprising:
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a) contacting a cell or tissue expressing GRP78 with a plurality of phage, wherein each phage comprises heterologous peptide sequences incorporated into a fiber protein, b) removing the phage that do not bind to the cell or tissue expressing GRP78, and c) isolating the phage that bind the cell or tissue expressing GRP78. - View Dependent Claims (67, 68)
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Specification