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Modified interferon-beta (IFN-beta) polypeptides

  • US 20080003202A1
  • Filed: 03/27/2007
  • Published: 01/03/2008
  • Est. Priority Date: 03/28/2006
  • Status: Abandoned Application
First Claim
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1. A modified IFN-β

  • polypeptide, comprising;

    one or more amino acid modifications in an unmodified IFN-β

    polypeptide, wherein;

    the one or more amino acid modifications correspond to modifications selected from among Y3I, Y3H, L6I, L6V, L6H, L6A, R11D, Q18S, Q18N, Q18H, Q18T, K19N, L20I, L20V, L20H, L20A, L21I, L21V, L21T, L21Q, L21H, L21A, Q23H, Q23S, Q23T, Q23N, L24I, L24V, L24T, L24Q, L24H, L24A, E29N, K33N, D34N, D34Q, D34G, F38I, F38V, D39N, P41A, P41S, E42N, E43N, E43K, E43Q, E43H, K45D, K45N, Q48H, Q48S, Q48T, Q48N, Q49H, Q49S, Q49T, Q49N, F50I, F50V, Q51H, Q51S, Q51T, Q51N, K52D, K52N, E53N, E53R, E53Q, E53H, D54K, D54N, D54G, D54Q, L57I, L57T, L57Q, L57H, Y60I, Y60H, E61K, E61H, E61N, E61Q, M62I, M62V, M62T, M62Q, L63I, L63V, L63T, L63Q, L63H, L63A, Q64H, Q64S, Q64T, Q64N, F70I, F70V, Q72H, Q72S, Q72T, Q72N, D73N, W79H, W79S, E81K, E81N, E85N, E85K, L87I, L87V, L87H, L87A, L88I, L88V, L88T, L88Q, L88H, L88A, L98I, L98V, L98H, L98A, K99N, L102I, L102V, L102T, L102Q, L102H, L102A, E103N, E103K, E104N, E104R, K105D, K105N, L106I, L106V, L106T, L106Q, L106H, L106A, E107N, E107R, K108D, K108N, E109R, E109N, D110K, D110N, R113E, K115D, K115N, K115S, K115H, K115Q, M117I, M117V, M117T, M117Q, M117A, L122I, L122V, L122T, L122Q, L122H, L122A, K123N, R124D, R124E, Y125I, Y125H, Y126I, Y126H, Y132I, Y132H, L133I, L133V, L133T, L133Q, L133H, L133A, K134N, K136N, E137N, W143H, W143S, R147H, R147Q, E149H, E149N, E149Q, L151I, L151V, L151T, L151Q, L511H, L151A, R152D, F154V, F154I, F156I, L160I, L160V, L160T, L160Q, L160H, L160A, L164I, L164V, L164T, L164Q, L164H, L164A, and R165D in the mature IFN-β

    polypeptide set forth in SEQ ID NO;

    1.

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