Novel human proteases and polynucleotides encoding the same

• US 20080003673A1
• Filed: 09/06/2005
• Published: 01/03/2008
• Est. Priority Date: 09/02/1999
• Status: Abandoned Application

• Current Assignee: Lexicon Genetics, Incorporated
• Original Assignee: Lexicon Genetics, Incorporated
• Inventors: Olson, Andrew, Hu, Yi, Friddle, Carl, Yu, Xuanchuan, Kieke, James, Scoville, John, Nehls, Michael, Friedrich, Glenn, Hilbun, Erin, Sands, Arthur, Wilganowski, Nathaniel, Nepomnichy, Boris, Turner, C., Donoho, Gregory, Gerhardt, Brenda, Walke, D., Miranda, Maricar, Zambrowicz, Brian, Abuin, Alejandro
• Application Number:
  US11/220,398
• Publication Number:
  US 20080003673A1
• Time in Patent Office: Days
• US Class Current: 435/320.1
• CPC Class Codes: C12N 9/6421 from mammals

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated nucleic acid molecule that encodes the amino acid sequence of SEQ ID NO:

2, 4, 6, 8, 11, 13, 15, 17, 19, 21, 24, 26, 28, 30, 32, 34, 36, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 71, 73, 75, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 105, 107, 109, 111, 113, 115, 117, 119, 122, 125, 128, 130, 132, 134, 136, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159, 162, 165, 167, 169, 172, 174, 177, 179, 181, 183, 185, 187, 190, 192, 194, 196, 199, 201, 203, 205, 207, 210, 213, 215, 218, or 221.

2. The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

1, 3, 5, 7, 10, 12, 14, 16, 18, 20, 23, 25, 27, 29, 31, 33, 35, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 63, 65, 67, 70, 72,74, 77, 79, 81, 83, 85, 87, 89, 91, 93, 95, 97, 99, 101, 104, 106, 108, 110, 112, 114, 116, 118, 121, 124, 127, 129, 131, 133, 135, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 161, 164, 166, 168, 171, 173, 176, 178, 180, 182, 184, 186, 189, 191, 193, 195, 198, 200, 202, 204, 206, 209, 212, 214, 217, or 220.

3. An expression vector comprising the isolated nucleic acid molecule of claim 1.

4. (canceled)

5. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:

2, 4, 6, 8, 11, 13, 15, 17, 19, 21, 24, 26, 28, 30, 32, 34, 36, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 71, 73, 75, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 105, 107, 109, 111, 113, 115, 117, 119, 122, 125, 128, 130, 132, 134, 136, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159, 162, 165, 167, 169, 172, 174, 177, 179, 181, 183, 185, 187, 190, 192, 194, 196, 199, 201, 203, 205, 207, 210, 213, 215, 218, or 221.

6. An antibody that selectively binds a polypeptide drawn from the group consisting of:

SEQ ID NO;

2, 4, 6, 8, 11, 13, 15, 17, 19, 21, 24, 26, 28, 30, 32, 34, 36, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 71, 73, 75, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 105, 107, 109, 111, 113, 115, 117, 119, 122, 125, 128, 130, 132, 134, 136, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159, 162, 165, 167, 169, 172, 174, 177, 179, 181, 183, 185, 187, 190, 192, 194, 196, 199, 201, 203, 205, 207, 210, 213, 215, 218, and 221.

7. An oligonucleotide that inhibits the expression of a nucleic acid molecule that encodes an amino acid sequence drawn from the group consisting of SEQ ID NO:

2, 4, 6, 8, 11, 13, 15, 17, 19, 21, 24, 26, 28, 30, 32, 34, 36, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 64, 66, 68, 71, 73, 75, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 105, 107, 109, 111, 113, 115, 117, 119, 122, 125, 128, 130, 132, 134, 136, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 159, 162, 165, 167, 169, 172, 174, 177, 179, 181, 183, 185, 187, 190, 192, 194, 196, 199, 201, 203, 205, 207, 210, 213, 215, 218, and 221.