USE OF HMGB1 FOR PROTECTION AGAINST ISCHEMIA REPERFUSION INJURY
First Claim
1. A method of protecting an organ or tissue from ischemic injury comprising administering administration of a High Mobility Group Box 1 (HMGB1) protein to the organ or tissue, wherein the HMGB1 protein is administered in an amount effective to protect the organ or tissue from injury, and wherein the HMGB1 protein is administered within a time period sufficient to protect the organ or tissue from injury.
4 Assignments
0 Petitions
Accused Products
Abstract
Methods and compositions are disclosed for protecting an organ or tissue from inflammation and organ injury following ischemia, reperfusion, and trauma through the administration of an HMGB1 protein within a time period sufficient to protect the organ or tissue from injury.
-
Citations
68 Claims
- 1. A method of protecting an organ or tissue from ischemic injury comprising administering administration of a High Mobility Group Box 1 (HMGB1) protein to the organ or tissue, wherein the HMGB1 protein is administered in an amount effective to protect the organ or tissue from injury, and wherein the HMGB1 protein is administered within a time period sufficient to protect the organ or tissue from injury.
- 2. A method of protecting an organ or tissue from injury resulting from ischemia and reperfusion comprising administration of an HMGB1 protein to the organ or tissue prior to completion of reperfusion, wherein the HMGB1 protein is administered in an amount effective to protect the organ or tissue from injury.
-
5. A method of protecting an organ or tissue from traumatic injury comprising administration of an HMGB1 protein to the organ or tissue, wherein the HMGB1 protein is administered in an amount effective to protect the organ or tissue from injury, and wherein the HMGB1 protein is administered within a time period sufficient to protect the organ or tissue from injury.
- 48. A method of preparing an organ or tissue for transplantation from a donor into a recipient comprising administration of an HMGB1 protein to the donor, wherein the organ or tissue is within the donor.
- 55. A method of preparing an organ or tissue for implantation into a recipient comprising administration of an HMGB1 protein to the organ or tissue ex vivo.
- 58. A composition for the prevention of injury to an organ following ischemia and reperfusion, comprising an HMGB1 protein and a pharmaceutically acceptable carrier.
-
61. A kit comprising a composition for the prevention of injury to an organ following isehemia and reperfusion and suitable instructions for administration, and optionally comprising a means for administration of the composition, wherein the composition comprises an HMGB1 protein and a pharmaceutically acceptable carrier.
- 62. Use of an HMGB1 protein in preparation of a medicament for use in protecting an organ from injury caused by an event selected from the group consisting of ischemia, reperfusion, and trauma.
Specification