Electrophysiological approaches to assess resection and tumor ablation margins and responses to drug therapy
First Claim
1. A method for determining the location of a tumor margin comprising:
- measuring a first electrophysiological characteristic of an area of tissue to be removed;
measuring a second electrophysiological characteristic of an area of normal tissue; and
determining the location of a tumor margin based on the difference in the first electrophysiological characteristic of the area of tissue to be removed and the second electrophysiological characteristic of the area of normal tissue.
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Abstract
A method and system are provided for determining a condition of a selected region of tissue to facilitate the location of surgical resection margins. Electropotential and impedance are measured at one or more locations in an area of the body where tissue is to be removed. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics of that tissue. The condition of the tissue is measured by electropotential and impedance profile. Differences in the profile are used to determine the borders between normal and abnormal tissue so as to facilitate what tissue to resect. Methods and apparatus are also disclosed to determine the efficacy of various therapies.
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Citations
41 Claims
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1. A method for determining the location of a tumor margin comprising:
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measuring a first electrophysiological characteristic of an area of tissue to be removed;
measuring a second electrophysiological characteristic of an area of normal tissue; and
determining the location of a tumor margin based on the difference in the first electrophysiological characteristic of the area of tissue to be removed and the second electrophysiological characteristic of the area of normal tissue. - View Dependent Claims (2, 3, 4, 5)
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6. A method for determining the location of a tumor margin comprising:
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measuring a first plurality of electrophysiological characteristics of an area of tissue to be removed at a first location;
measuring a second plurality of electrophysiological characteristics of an area of normal tissue at a second location; and
determining the location of a tumor margin based on the difference in first and second pluralities of electrophysiological characteristics. - View Dependent Claims (7, 8, 9)
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10. An apparatus for determining the location of a tumor margin comprising:
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a first electrode for measuring a first electrophysiological characteristic of an area of tissue to be removed;
a second electrode for measuring a second electrophysiological characteristic of an area of normal tissue; and
a device operative to determine the difference between the first and second electrophysiological characteristics. - View Dependent Claims (11, 12)
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13. An apparatus for determining an area of tissue to be removed from a body comprising:
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a first electrode for measuring a first electrophysiological characteristic of an area of tissue to be removed;
a second electrode for measuring a second electrophysiological characteristic of an area of normal tissue;
a device operative to display the first and second electrophysiological characteristics. - View Dependent Claims (14, 15, 16, 17, 18)
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19. An apparatus for determining an area of tissue to be removed comprising:
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a first electrode for measuring a first electrophysiological characteristic of an area of tissue to be removed;
a second electrode for measuring a second electrophysiological characteristic of an area of normal tissue;
a first device operative to display the first electrophysiological characteristic; and
a second device operative to display the second electrophysiological characteristic. - View Dependent Claims (20)
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21. A computer-readable medium having computer-executable instructions for performing a method comprising:
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measuring an electrophysiological characteristic of an area of tissue to be removed from an area of normal tissue;
determining the location of a resection margin between the area of tissue to be removed and the area or normal tissue based on the difference in the electrophysiological characteristic of the area of tissue to be removed from known values of the electrophysiological characteristic of normal tissue.
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22. A computer-readable medium having computer-executable instructions for performing a method comprising:
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measuring a first electrophysiological characteristic of an area of tissue to be removed;
measuring a second electrophysiological characteristic of an area of normal tissue; and
determining the location a margin between the area of tissue to be removed and the area or normal tissue based on the difference in the first electrophysiological characteristic of the area of tissue to be removed and the second electrophysiological characteristic area of normal tissue. - View Dependent Claims (23, 24, 25)
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26. A method for determining the resection margin of an area of tissue comprising:
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measuring a plurality of electrophysiological characteristics of an area of tissue to be removed from an area of normal tissue; and
determining the location of a resection margin between the area of tissue to be removed and the area or normal tissue based on the difference in the electrophysiological characteristics of the area of tissue to be removed and known electrophysiological characteristics of normal tissue. - View Dependent Claims (27, 28, 29, 30)
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31. A method for facilitating the removal of an area of tissue comprising:
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measuring the electrophysiological characteristic of the area of tissue to be removed;
comparing the electrophysiological characteristic of the area of tissue to be removed to the electrophysiological characteristic of an area of normal tissue; and
determining the location of the area of tissue to be removed based on the comparison between the first electrophysiological characteristic of the area of tissue to be removed and the electrophysiological characteristic of an area of normal tissue.
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32. A method for determining the efficacy of a form of medical treatment comprising:
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measuring a first electrophysiological characteristic of an area of tissue to be treated;
applying a treatment to the area of tissue to be treated;
measuring a second electrophysiological characteristic of the area of tissue to be treated;
comparing the first and second electrophysiological characteristics; and
determining the efficacy of the medical treatment based on the comparison between the first and second electrophysiological characteristics. - View Dependent Claims (33)
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34. A method for determining the efficacy of a form of medical treatment comprising:
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applying a treatment to an area of tissue;
measuring an electrophysiological characteristic of the area of tissue;
comparing the electrophysiological characteristic of the area of tissue to predetermined values;
determining the efficacy of the medical treatment based on the comparison between the electrophysiological characteristic and predetermined values.
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35. A method for determining the efficacy of a form of medical treatment comprising:
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applying a treatment to the area of tissue to be treated;
measuring a first electrophysiological characteristic of the area of treated tissue;
measuring a second electrophysiological characteristic of a second area of tissue;
comparing the first and second electrophysiological characteristics; and
determining the efficacy of the medical treatment based on the comparison between the first and second electrophysiological characteristics. - View Dependent Claims (36, 37, 38)
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39. An apparatus for determining the efficacy of a form of treatment comprising:
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a first electrode for measuring a first electrophysiological characteristic of an area of tissue to be treated;
a second electrode for measuring a second electrophysiological characteristic of an area of normal tissue;
a first device operative to display the first electrophysiological characteristic; and
a second device operative to display the second electrophysiological characteristic.
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40. An apparatus for determining the efficacy of a form of treatment comprising:
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a first electrode for measuring a first electrophysiological characteristic of an area of tissue to be treated;
a second electrode for measuring a second electrophysiological characteristic of an area of normal tissue;
a device operative to determine the difference between the first and second electrophysiological characteristics.
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41. A computer-readable medium having computer-executable instructions for performing a method for determining the efficacy of a form of treatment comprising:
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applying a treatment to an area of tissue;
measuring an electrophysiological characteristic of the area of tissue;
comparing the electrophysiological characteristic of the area of tissue to an electrophysiological characteristic of normal tissue; and
determining the efficacy of the medical treatment based on the comparison between the electrophysiological characteristic of the area of tissue and the electrophysiological characteristic of normal tissue.
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Specification