Methods and systems for neural maintenance and regeneration
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Abstract
Methods and systems are described that release one or both of a neurotrophin and an inhibitor of the degradation of the neurotrophin within or in the vicinity of a highly innervated tissue. In some embodiments, the method includes regulating the release of the neurotrophin and the inhibitor of degradation over time. In some embodiments, the method includes monitoring the concentration of the neurotrophin over time. The system may include a device or multiple devices for the release of the neurotrophin and the inhibitor as well as a controller. In some embodiments the system may include a sensor device and/or an imaging device capable of detecting the concentration of the neurotrophin over time. The release of the neurotrophin and inhibitor of degradation may be part of a controlled release system and regulated over time.
49 Citations
119 Claims
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1-105. -105. (canceled)
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106. A system for modulating the concentration of a neurotrophin comprising:
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A sensor capable of detecting the concentration of the neurotrophin in a region of a nervous system of a subject;
b. A memory device capable of storing a target concentration;
c. A processor capable of comparing said detected concentration with said target concentration to compute a quantity of a composition to be released to adjust said detected concentration toward said target concentration;
d. A control signal generator capable of generating a control signal representing said computed quantity; and
e. A controlled release device controllable by said control signal to release said composition in the vicinity of said sensory organ. - View Dependent Claims (107, 108, 109, 111, 114, 115, 118)
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110. (canceled)
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112. (canceled)
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113. (canceled)
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116. (canceled)
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117. (canceled)
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119-127. -127. (canceled)
Specification