Implantable device with light-transmitting material

• US 20080004686A1
• Filed: 06/25/2007
• Published: 01/03/2008
• Est. Priority Date: 06/30/2006
• Status: Abandoned Application

• Current Assignee: Cook Incorporated (Cook Group Incorporated)
• Original Assignee: Cook Incorporated (Cook Group Incorporated)
• Inventors: Hunt, James, Agnew, Charles, Paul, Ram
• Application Number:
  US11/821,610
• Publication Number:
  US 20080004686A1
• Time in Patent Office: Days
• US Class Current: 623/1.11
• CPC Class Codes: A61B 2017/005 hardenable using external energy source, e.g. laser, ultrasound
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2475 Venous valves
• CPC Class Codes: A61F 2002/30448 using adhesives
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2250/0039 differing in diameter
• CPC Class Codes: A61F 2250/0053 differing in optical properties
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Abstract

Endolumenal medical devices for implantation within a body vessel are provided. The medical devices may comprise a light-transmitting area having an adhesive-activating effective transmittance at a wavelength suitable for activating a light-activated adhesive. The light-activated adhesive is preferably positioned on the medical device and may be activated by illumination inside a body vessel with light of a suitable wavelength, including ultraviolet, visible or infrared radiation, to secure the medical device within a body vessel. The light may be provided by a light-emitting catheter within the body vessel, and the medical device may be configured as a radially-expandable valve comprising one or more valve leaflets.

Claims

1. An endolumenal medical device delivery system comprising:

a. a light source adapted to emit light at a first wavelength and

b. an endoluminal medical device having an interior surface defining a lumen and an exterior surface, the endolumenal medical device including;

i. a light-transmitting area positioned between the interior surface and the exterior surface, the light-transmitting area having an adhesive-activating transmittance at the first light wavelength; and

ii. a light-activated adhesive positioned and configured to permit light passing through the transmitting area to contact the light-activated adhesive, the light-activated adhesive being activated by the light at the first wavelength.

2. The endolumenal medical device delivery system of claim 1, wherein the light-activated adhesive is in contact with at least a portion of the exterior surface.

3. The endolumenal medical device delivery system of claim 1, wherein the light source includes a catheter containing a light-emitting portion.

4. The endolumenal medical device delivery system of claim 1, wherein the first wavelength is ultraviolet, visible or infrared light.

5. The endolumenal medical device delivery system of claim 1, wherein the first wavelength is between about 200 nm and about 450 nm.

6. The endolumenal medical device delivery system of claim 1, wherein the light-activated adhesive comprises a material selected from the group consisting of:

N-vinyl pyrollidone (NVP), 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS), vinylsuccinimide (VS), 2-isocyanatoethyl methacrylate (IEM) or glycidyl acrylate (GA), poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG), benzophenone, xanthene dye, poly(ethylene glycol)diacrylate (PEGDA), 2,2-bis(4-ethoxyacrylatephenyl)propane (HEPAC), 2,2-bis(4-ethoxyacrylatephenyl)6-Fpropane (HEPFAAC), 2,2-bis(4-ethoxyacrylate-3,5-dibromophenyl)propane (TBHEPAAC), 5-tert-butyl-1,2-bis(4-ethoxy-acrylate benzoyl)benzene (tBuHEPBAC), gelatin, cinnamate, coumarin and thymine, or a copolymer of two or more of the materials.

7. The endolumenal medical device delivery system of claim 1, wherein the endolumenal medical device is configured as a stent graft comprising graft material forming the light-transmitting area.

8. The endolumenal medical device delivery system of claim 1, wherein the endolumenal medical device is configured as a radially-expandable endolumenal valve.

9. The endolumenal medical device delivery system of claim 8, wherein the endolumenal medical device is adapted for endovascular implantation in a vein or a heart.

10. The endolumenal medical device delivery system of claim 1, wherein the endolumenal medical device is configured as a valve comprising a valve leaflet forming the transmitting surface.

11. The endolumenal medical device delivery system of claim 1, wherein the endolumenal medical device includes an extracellular matrix material forming at least a portion of the light-transmitting area.

12. The endolumenal medical device delivery system of claim 1, wherein the endolumenal medical device is a valve including at least one leaflet comprising small intestine submucosa forming at least a portion of the light-transmitting area.

13. The endolumenal medical device delivery system of claim 1, wherein:

a. the light source is a catheter comprising an expandable balloon, a light source and a light-transmitting portion, the catheter adapted to emit light at the first wavelength within a body lumen; and

b. the endolumenal medical device is a radially expandable valve comprising a support frame and a valve leaflet attached to the support frame, the valve leaflet defining a portion of the exterior surface and a portion of the interior surface and including a portion of the light-transmitting area, and a portion of the interior surface of the radially expandable valve circumferentially enclosing a portion of the catheter.

14. The endolumenal medical device delivery system of claim 13, wherein the light-activated adhesive is also in contact with a portion of the support frame.

15. The endolumenal medical device delivery system of claim 13, wherein the light-activated adhesive is in contact with the valve leaflet.

16. The endolumenal medical device delivery system of claim 13, wherein the first wavelength is ultraviolet, visible or infrared light.

17. A method of manufacturing a radially expandable medical device comprising:

a. attaching at least one light-transmitting material to a radially expandable support frame, the light-transmitting material comprising an extracellular matrix material forming a transmitting area having an adhesive-activating transmittance at a first light wavelength;

the valve being moveable from a radially compressed delivery configuration to a radially expanded configuration;

b. contacting the transmitting area of the extracellular matrix material of the valve leaflet with a hydrating fluid in a manner effective to absorb the hydrating fluid into the extracellular matrix material to form a hydrated valve leaflet; and

c. applying a light-activated adhesive to at least a portion of the support frame or the hydrated valve leaflet to form an adhesive surface comprising the light-activated adhesive positioned and configured to permit light passing through the light-transmitting area contacts the adhesive surface.

18. A method of treatment comprising the steps of:

a. positioning an endolumenal medical device having an interior surface defining a lumen and an exterior surface in contact with a body vessel, the medical device comprising a light-transmitting area and a light-activated adhesive, the light-transmitting area having an adhesive-activating transmittance at a first light wavelength;

the light-activated adhesive positioned and configured to permit light passing through the light-transmitting area to contact the light-activated adhesive, the light-activated adhesive being activated by light of the first wavelength; and

b. illuminating the light-activated adhesive within the body vessel with light of the first light wavelength in a manner effective to activate the light-activated adhesive within the body vessel.

19. The method of claim 18, wherein the light-activated adhesive contacts the wall of the body vessel after positioning the endolumenal medical device within the body vessel and illuminating the light-activated adhesive secures a portion of the light-transmitting area to the wall of the body vessel.

20. The method of claim 18, wherein the endolumenal medical device is a first endolumenal medical device, the light-activated adhesive is positioned on the interior surface of the endolumenal medical device and the method further comprises the steps of:

c. inserting a second endolumenal medical device into the body vessel and contacting the second endolumenal medical device with the light-activated adhesive on the interior surface of the first endolumenal medical device;

the step of illuminating the light-activated adhesive being effective to join the first endolumenal medical device to the first endolumenal medical device; and

d. removing the first endoluminal device and the second endolumenal medical device from the body vessel.