EVEROLIMUS/PIMECROLIMUS-ELUTING IMPLANTABLE MEDICAL DEVICES

• US 20080004695A1
• Filed: 06/26/2007
• Published: 01/03/2008
• Est. Priority Date: 06/28/2006
• Status: Abandoned Application

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Consigny, Paul, Zhang, Gina, Stewart, Gordon, Park, Gene
• Application Number:
  US11/768,749
• Publication Number:
  US 20080004695A1
• Time in Patent Office: Days
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/436 the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution

Abstract

An implantable medical device including a polymer matrix containing everolimus and pimecrolimus, and methods of using the device for the treatment of vascular disease are disclosed.

Claims

1. An implantable medical device comprising:

a polymeric matrix disposed over the device, wherein the polymeric matrix comprises everolimus and pimecrolimus.

2. The implantable medical device according to claim 1, wherein the polymeric matrix comprises ethylene vinyl alcohol, poly(butyl methacrylate) or poly(vinylidene fluoride-co-hexafluoropropene).

3. The implantable medical device according to claim 1, wherein the implantable medical device is a stent.

4. A method for treating or preventing vascular disease comprising:

implanting the medical device according to claim 1 in a vessel of a patient in need thereof.

5. The method according to claim 4, wherein the vascular disease is atherosclerosis, restenosis, vulnerable plaque or a peripheral arterial disease.

6. A method for coating an implantable medical device comprising:

applying a composition comprising a polymer, everolimus and pimecrolimus to the implantable medical device; and

forming a coating comprising the composition on the implantable medical device.

7. The method according to claim 6, wherein the polymer comprises ethylene vinyl alcohol, poly(butyl methacrylate) or poly(vinylidene fluoride-co-hexafluoropropene).

8. The method according to claim 6, wherein the implantable medical device is a stent.