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COMBINATIONS OF MEDIUM CHAIN TRIGLYCERIDES AND THERAPEUTIC AGENTS FOR THE TREATMENT AND PREVENTION OF ALZHEIMERS DISEASE AND OTHER DISEASES RESULTING FROM REDUCED NEURONAL METABOLISM

  • US 20080009467A1
  • Filed: 06/29/2007
  • Published: 01/10/2008
  • Est. Priority Date: 05/01/2000
  • Status: Abandoned Application
First Claim
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1. A composition for the treatment of or prevention of Alzheimer'"'"'s disease or mild cognitive impairment, comprising:

  • i) medium chain triglycerides (MCT) of the formula;

    wherein the R1, R2, and R3 esterified to the glycerol backbone are each independently fatty acids having 5-12 carbon chains in an amount effective for the treatment of or prevention of loss of cognitive function in a mammal caused by reduced neuronal metabolism in dementia of Alzheimer'"'"'s type or mild cognitive impairment; and

    ii) a therapeutic agent selected from the group consisting of anti-Alzheimer'"'"'s agents, anti-diabetic agents, agents capable of increasing utilization of lipids, anti-atherosclerotic agents, anti-hypertensive agents, anti-inflammatory agents, anti-obesity agents, and combinations thereof.

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