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BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS

  • US 20080009520A1
  • Filed: 09/20/2007
  • Published: 01/10/2008
  • Est. Priority Date: 10/02/2001
  • Status: Abandoned Application
First Claim
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1. A method of treating mental disease or disorder in a mammal comprising identifying a mammal in need thereof and administering at least one compound of Formula I to said mammal:

  • or a pharmaceutically acceptable salt or prodrug thereof, wherein;

    X is selected from the group consisting of CH, O, N and S;

    Z is selected from the group consisting of CH and N;

    Y is selected from the group consisting of ═

    O, ═

    NH and ═

    S or tautomers thereof;

    -SPU- is a biradical selected from the group consisting of —

    (CR6R7)n-A- and —

    C3-8-cycloalkyl-, wherein n is 1, 2, 3, 4, or 5;

    A is absent or an optionally substituted —

    C3-8-cycloalkyl;

    N together with R1 and R2 form a heterocyclic ring wherein said heterocyclic ring is 8-azabicyclo[3.2.1]octane, wherein the heterocyclic ring is substituted with one or more substituents R4 selected from the group consisting of halogen, C1-8-alkyl, C3-8-cycloalkyl, C1-8-alkoxy, C1-8-alkylcarbonyl, C1-8-alkylidene, C2-8-alkenyl, C2-8-alkynyl, C1-6-alkyloxyimino, and C1-6-alkyloxyamino each of which may be optionally substituted with a substituent R5, and wherein at least one of said substituents R4 is R4

    selected from the group consisting of C1-8-alkyl, C3-8-cycloalkyl, C1-8-alkoxy, C1-8-alkylcarbonyl, C1-8-alkylidene, each of which may be optionally substituted with a substituent R5;

    R5 is selected from the group consisting of hydrogen, halogen, hydroxy, C1-8-alkyl, C1-8-alkoxy, C3-8-cycloalkyl, C3-8-heterocyclyl, C1-8-alkylcarbonyl, C1-8-alkylidene, C2-8-alkenyl and C2-8-alkynyl;

    RX may be absent or selected from the group consisting of hydrogen, optionally substituted C1-8-alkyl, optionally substituted C3-8-cycloalkyl, optionally substituted C2-8-alkenyl, optionally substituted C2-8-alkynyl, CH2

    N(R5)(R5), CH2

    OR5, CH2

    SR5, and CH2

    O—

    C(═

    O)R5;

    R3 may be present 0-4 times and selected from the group consisting of halogen, hydroxy, optionally substituted C1-8-alkyl, C1-8-alkoxy, optionally substituted C1-8-alkylidene, optionally substituted C2-8-alkenyl, optionally substituted C2-8-alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C3-8-cycloalkyl, optionally substituted C3-8-heterocyclyl, and optionally substituted C1-8-alkylcarbonyl; and

    each R6 and each R7 is optionally and independently selected from the group consisting of hydrogen, halogen, hydroxy, optionally substituted C1-8-alkyl, C1-8-alkoxy, optionally substituted C1-8-alkylidene, optionally substituted C2-8-alkenyl, optionally substituted C2-8-alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C3-8-cycloalkyl, optionally substituted C3-8-heterocyclyl, and optionally substituted C1-8-alkylcarbonyl.

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