Surface injection device
First Claim
1. A needle-free transdermal transport device for transferring a substance across a surface of a biological body comprising:
- a reservoir for storing the substance;
a nozzle in fluid communication with the reservoir and adapted to be pressed against and depress without piercing, the surface of the biological body;
a laterally directed aperture in the nozzle; and
an actuator in communication with the reservoir that generates a pressure within the reservoir when activated, that injects the substance laterally through the aperture into the biological body by piercing the surface of the biological body.
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Accused Products
Abstract
A needle-free transdermal transport device for non-axially transferring a substance across a surface of a biological body includes a reservoir for holding a substance being transferred. A piston is positioned within the device in communication with the reservoir. An actuator drives the piston to expel the substance from the reservoir. The reservoir is in fluid communication with a nozzle which includes at least one lateral aperture through which the substance is expelled. Multiple lateral apertures can result in a needle-free transfer across a selectable surface area. The depth and direction of an injection can be controlled by the parameters of the nozzle. By providing a selective depth and direction, it is possible to inject a substance into a targeted biological layer, such as a cleavage plane to further promote coverage. A control source can be used to activate the device. The device can also include an optional power source.
69 Citations
16 Claims
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1. A needle-free transdermal transport device for transferring a substance across a surface of a biological body comprising:
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a reservoir for storing the substance;
a nozzle in fluid communication with the reservoir and adapted to be pressed against and depress without piercing, the surface of the biological body;
a laterally directed aperture in the nozzle; and
an actuator in communication with the reservoir that generates a pressure within the reservoir when activated, that injects the substance laterally through the aperture into the biological body by piercing the surface of the biological body. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method for transdermally transferring a substance across a surface of a body comprising the steps of:
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pressing a nozzle in fluid communication with a reservoir, against the surface of the body and depressing without piercing, the surface of the body;
activating an actuator in communication with the reservoir to generate a pressure within the reservoir; and
injecting the substance through a laterally directed aperture in the nozzle to induce lateral, needle-free injection of the substance. - View Dependent Claims (9, 10, 11)
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12. A method of manufacturing a nozzle adapted to transfer a substance non-axially to a surface of a body comprising:
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providing an elongated member defining a central lumen;
positioning one end of the elongated member such that it is in close proximity with an Electro Spark Discharge (ESD) wire; and
energizing the ESD wire to vaporize the end of the elongated member, thereby forming a non-axial aperture, adapted to transfer the substance to the surface of the biological body. - View Dependent Claims (13, 14, 15)
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16. A needle-free transdermal transport device for transferring a substance across a surface of a biological body comprising:
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means for activating an actuator in communication with a reservoir to generate a pressure within the reservoir; and
means for injecting the substance through a laterally directed aperture in the nozzle to induce lateral, needle-free injection of the substance.
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Specification