Blood/Air Mass Exchange Apparatus

• US 20080014115A1
• Filed: 05/27/2005
• Published: 01/17/2008
• Est. Priority Date: 06/03/2004
• Status: Abandoned Application

• Current Assignee: Haemair Limited
• Original Assignee: Haemair Limited
• Inventors: Johns, William
• Application Number:
  US11/628,312
• Publication Number:
  US 20080014115A1
• Time in Patent Office: Days
• US Class Current: 422/46
• CPC Class Codes: A61M 1/1678 intracorporal peritoneal dialysis A61M1/28
• CPC Class Codes: A61M 1/1698 Blood oxygenators with or without heat-exchangers intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: A61M 2205/07 having air pumping means
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/279 Peristaltic pumps, e.g. roller pumps
• CPC Class Codes: A61M 60/882 Devices powered by the patient, e.g. skeletal muscle powered devices

Abstract

There is provided a mass exchange apparatus for use in blood/air mass exchange comprising plural blood flow conduits for defining blood flow; and plural air flow conduits for defining air flow. The plural air flow conduits and the plural blood flow conduits at least partially comprise gas-permeate membrane material, and the conduits are arranged relative to each other such as to enable transfer of oxygen from the air to the blood and transfer of carbon dioxide from the blood to the air. The blood and air do not directly come into contact (i.e. the mass exchange is indirect). There is also provided a prosthetic lung comprising an elastic bellows and the at least one mass exchange apparatus herein. There is further provided an external respiratory aid to augment patient lung function comprising the at least one mass exchange apparatus herein and means to pump air and blood through the apparatus. There is further provided an intermediate respiratory aid apparatus for internal connection to a patient comprising at least one mass exchange apparatus herein and an air pump.

Claims

1. A mass exchange apparatus for use in blood/air mass exchange comprising

(a) plural blood flow conduits for defining blood flow;

and

(b) plural air flow conduits for defining air flow;

wherein said plural air flow conduits and said plural blood flow conduits at least partially comprise gas-permeable membrane material, and the conduits are arranged relative to each other such as to enable transfer of oxygen from the air to the blood and transfer of carbon dioxide from the blood to the air through said membrane material.

2. A mass exchange apparatus according to claim 1, wherein said air flow is arranged to be a combination of air flow that is counter-current to the blood flow and air flow that is co-current to the blood flow.

3. A mass exchange apparatus according to claim 1, wherein the air flow includes recycled air flow.

4. A mass exchange apparatus according to claim 1, wherein the blood flow conduits and/or air flow conduits have a diameter of less than 0.5 millimetres.

5. A mass exchange apparatus according to claim 1, wherein the blood flow conduits and air flow conduits are defined by a series of plates that are separated by a distance of less than 0.5 millimetres.

6. A mass exchange apparatus according to claim 1, additionally including a sensor for sensing a patient'"'"'s demand for oxygen.

7. A mass exchange apparatus according to claim 6, wherein the sensor senses the pulse rate of a patient.

8. A mass exchange apparatus according to claim 1, additionally including a controller for controlling the rate of blood/air mass exchange.

9. A mass exchange apparatus according to claim 8, wherein said controller is responsive to the sensor.

10. A mass exchange apparatus according to claim 1, wherein said gas-permeable membrane material comprises a hollow fibre membrane comprising poly-4-methylpentene-1 and having an oxygen permeation rate Q(02) at 25 C of from 1×

10<sup>−

6</sup> to 3×

10<sup>−

3</sup> (cm (STP)/cm.sec.cmHg) and an ethanol flux of from 0.1 to 100 ml/min.m, wherein said membrane has a surface comprising an ionic complex derived from;

quaternary aliphatic alkylammonium salts; and

heparin or a heparin derivative, and wherein said quaternary alkylammonium salts comprise a quaternary aliphatic alkylammonium salt having from 22 to 26 carbon atoms in total and a quaternary aliphatic alkylammonium salt having from 37 to 40 carbon atoms in total.

11. An association of plural mass exchange apparatus according to claim 1, defining a combined mass-transfer area of from 5 to 20 square metres.

12. A prosthetic lung comprising (a) at least one mass exchange apparatus according to claim 1;

and (b) bellows or air sac means for supplying air flow to the air flow conduits.

13. A prosthetic lung according to claim 12, wherein said mass exchange apparatus locates within said bellows.

14. A respiratory aid apparatus for external connection to a patient comprising (a) at least one mass exchange apparatus according to claim 1;

(b) an air pump for pumping air through said air conduits; and

(c) a blood pump for pumping blood through said blood conduits.

15. A respiratory aid apparatus according to claim 14, additionally comprising an air filter for filtering the air.

16. A respiratory aid apparatus according to either claim 1, comprising two mass exchange apparatus arranged in parallel fashion.

17. A respiratory aid apparatus according to claim 1, additionally comprising a humidifier for humidifying the air.

18. A respiratory aid apparatus according to claim 1, wherein input tubing to said blood pump is arranged to provide blood extraction and return via a single entry point in a vein of a patient.

19. A respiratory aid apparatus according to claim 18, wherein said input tubing is arranged concentrically.

20. A respiratory aid apparatus according to claim 1, arranged such that extracted blood undergoes counter-current heat transfer with returned blood.

21. A respiratory aid apparatus according to claim 1, additionally comprising a heat exchanger for preheating the air.

22. An intermediate respiratory aid apparatus for internal connection to a patient comprising (a) at least one mass exchange apparatus according to claim 1;

and (b) an air pump for pumping air through said air conduits.

23. An intermediate respiratory aid apparatus according to claim 22, wherein said at least one mass exchange apparatus is arranged to connect directly with a vein of a patient.