Food sterilization dosage indicator

• US 20080014117A1
• Filed: 07/14/2006
• Published: 01/17/2008
• Est. Priority Date: 07/14/2006
• Status: Abandoned Application

• Current Assignee: Questel Adhesives
• Original Assignee: Questel Adhesives
• Inventors: Questel, John M., Sokolowski, Christian D.
• Application Number:
  US11/486,811
• Publication Number:
  US 20080014117A1
• Time in Patent Office: Days
• US Class Current: 422/56
• CPC Class Codes: A61L 2/28 Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour apparatus involving enzymes or microorganisms C12M1/34; methods involving enzymes or microorganisms C12Q1/00
• CPC Class Codes: G01N 31/226 for investigating the degree of sterilisation

Abstract

A multilayer food sterilization dosage indicator having (a) an indicator layer including an ion-sensitive ink, an ionic photoinitiator, a proton source; (b) a substrate, and an overlayer including a UV-absorber. The ink undergoes a color change upon exposure to a known amount of sterilizing radiation. A method for indicating the amount of exposure to sterilizing radiation using the dosage indicator.

Claims

1. A multilayer radiation dosage indicator comprising

(a) an indicator layer comprising an ion-sensitive ink, an ionic photoinitiator, and a proton source, wherein the ink undergoes a color change upon exposure to a known amount of sterilizing radiation;

(b) a substrate; and

(c) an overlayer comprising an UV-absorber.

2. The multilayer radiation dosage indicator of claim 1, wherein the substrate comprises paper, film, or foil, or combinations thereof.

3. The multilayer radiation dosage indicator of claim 1, wherein the ion-sensitive ink comprises bromochlorophenol blue sodium salt, bromocresol green ACS, bromocresol green sodium salts ACS, bromocresol purple, bromocresol purple sodium salt, bromopyrogallol red, bromothymol blue ACS, bromothymol blue sodium salt ACS, bromoxylenol blue, chlorophenol red, o-cresolphthalein complexone, o-cresolphthalein complexone disodium salt, m-cresol purple, m-cresol purple sodium salt, cresol red, cresol red sodium salt, erichrome blue black R, ethyl orange sodium salt, fast sulphon black F, litmus powder, methyl orange ACS, methyl red free acid ACS, methyl red HCl ACS, methyl red sodium salt ACS, methylthymol blue, murexide powder, nitrazine yellow, or P.A.N.

4. The multilayer radiation dosage indicator of claim 1, wherein said indicator layer further comprises a color enhancer.

5. The multilayer radiation dosage indicator of claim 1, wherein the overlayer comprises a UV-absorber selected from the group consisting of 2,2′

-dihydroxy-4-methoxybenzophenone, 2[hydroxy-5-t-octylphenyl]-benzotriazole, substituted benzophenones, substituted benzotriazoles, substituted acrylonitriles, and phenol-nickel complexes.

6. The multilayer radiation dosage indicator of claim 1, wherein the ionic photoinitiator comprises an iodonium salt or a sulphonium salt.

7. The multilayer radiation dosage indicator of claim 1, wherein the proton source comprises PVDC.

8. The multilayer radiation dosage indicator of claim 7, further comprising a removable layer selected from the group consisting of silicone coated release paper, and silicone coated plastic film.

9. The multilayer radiation dosage indicator of claim 1, further comprising an intermediate layer between said substrate layer and said indicator layer.

10. The multilayer radiation dosage indicator of claim 9, wherein said intermediate layer comprises aluminum foil, polyethylene terephthalate film, aluminum metallized mylar, or coated paper, with the proviso that the paper is coated with a barrier layer that is inert to said indicator layer.

11. A method for indicating an amount of exposure to sterilizing radiation, the method comprising the step of:

providing a multilayer radiation dosage indicator comprising;

(a) an indicator layer comprising an ion-sensitive ink, an ionic photoinitiator, and a proton source, wherein the ink undergoes a color change upon exposure to a known amount of sterilizing radiation;

(b) a substrate; and

(c) an overlayer comprising a UV-absorber;

exposing said indicator to sterilizing radiation until a color change is observed.

12. The method of claim 11, wherein the indicator layer comprises a substrate comprising paper, film, or foil, and wherein the paper, film, or foil comprises a white, opaque coating.

13. The method of claim 11, wherein the ion-sensitive ink comprises bromochlorophenol blue sodium salt, bromocresol green ACS, bromocresol green sodium salts ACS, bromocresol purple, bromocresol purple sodium salt, bromopyrogallol red, bromothymol blue ACS, bromothymol blue sodium salt ACS, bromoxylenol blue, chlorophenol red, o-cresolphthalein complexone, o-cresolphthalein complexone disodium salt, m-cresol purple, m-cresol purple sodium salt, cresol red, cresol red sodium salt, erichrome blue black R, ethyl orange sodium salt, fast sulphon black F, litmus powder, methyl orange ACS, methyl red free acid ACS, methyl red HCl ACS, methyl red sodium salt ACS, methylthymol blue, murexide powder, nitrazine yellow, or P.A.N.

14. The method of claim 11, wherein the overlayer comprises a colorless lacquer mixture formed from ingredients comprising ethyl cellulose and a binder.

15. The method of claim 14, wherein the lacquer mixture further comprises a UV absorber selected from the group consisting of 2,2′

-dihydroxy-4-methoxybenzophenone, 2[hydroxy-5-t-octylphenyl]-benzotriazole, substituted benzophenones, and substituted benzotriazoles.

16. The method of claim 11, wherein the photoinitiator comprises an iodonium salt or a sulphonium salt.

17. The method of claim 11, wherein the proton source comprises PVDC.

18. The method of claim 11, wherein the photoinitiator comprises bis(p-tolyl)iodonium hexafluorophosphate, or a substituted aryl sulfonium hexafluorophosphate salt.

19. The method of claim 11, further comprising an intermediate layer between said substrate layer and said indicator layer.

20. The method of claim 18, wherein said intermediate layer comprises aluminum foil, polyethylene terephthalate film, aluminum metallized mylar, or coated paper, with the proviso that the paper is coated with a barrier layer that is inert to said indicator layer.

21. A method for adjusting the selectivity of a multilayer radiation dosage indicator to sterilizing radiation, the method comprising the steps of:

providing a multilayer radiation dosage indicator comprising;

(a) an indicator layer comprising an ion-sensitive ink, an ionic photoinitiator and a proton source, wherein the link undergoes a color change upon exposure to a known amount of sterilizing radiation;

(b) a substrate; and

(c) an overlayer comprising a UV-absorber;

selecting the amount of UV-absorber in the overlayer to prevent the ink from changing color upon exposure to UV radiation.