Enhanced stability phenylephrine liquid compositions
First Claim
Patent Images
1. An oral liquid pharmaceutical composition comprising:
- a). phenylephrine; and
b). substantially aldehyde-free polyethylene glycol, wherein the substantially aldehyde-free polyethylene glycol has less than 20 ppm total aldehyde content and maintains said level of aldehyde content for at least six months.
1 Assignment
0 Petitions
Accused Products
Abstract
An oral, liquid pharmaceutical composition is provided. The composition comprises phenylephrine and substantially aldehyde-free polyethylene glycol. The composition has phenylephrine stability compatible with the stability required for commercial preparations. Optionally, the composition may comprise one or more additional active agents.
-
Citations
39 Claims
-
1. An oral liquid pharmaceutical composition comprising:
-
a). phenylephrine; and b). substantially aldehyde-free polyethylene glycol, wherein the substantially aldehyde-free polyethylene glycol has less than 20 ppm total aldehyde content and maintains said level of aldehyde content for at least six months. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. An aqueous oral pharmaceutical composition comprising:
-
a). phenylephrine; b). substantially aldehyde-free polyethylene glycol, wherein the substantially aldehyde-free polyethylene glycol has less than 20 ppm total aldehyde content and maintains said level of aldehyde content for at least six months; c). artificial sweetener; d). up to about 45% glycerin; and e). up to about 50% sorbitol. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 37, 38, 39)
-
-
29. An aqueous oral pharmaceutical composition comprising:
-
a). phenylephrine; b). substantially aldehyde-free polyethylene glycol, wherein the substantially aldehyde-free polyethylene glycol has less than 20 ppm total aldehyde content and maintains said level of aldehyde content for at least six months; c). an artificial sweetener; d a viscosity modifying agent; e). up to about 45% glycerin; and f). up to about 50% sorbitol. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36)
-
Specification