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Methods and compositions for inactivation of dihydrofolate reductase

  • US 20080015164A1
  • Filed: 05/17/2007
  • Published: 01/17/2008
  • Est. Priority Date: 05/19/2006
  • Status: Abandoned Application
First Claim
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1. A protein comprising an engineered zinc finger protein DNA-binding domain, wherein the DNA-binding domain comprises four zinc finger recognition regions ordered F1 to F4 from N-terminus to C-terminus, and wherein F1, F2, F3, and F4 comprise the following amino acid sequences:

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