COMPOSITIONS FOR DELIVERY OF THERAPEUTICS AND OTHER MATERIALS
First Claim
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1. A composition with a metal bridge comprising:
- a first hydrophobic group with a first metal binding domain (FMBD) at one end;
a metal ion chelated to the FMBD;
an active agent with a second metal binding domain (SMBD) chelated to the said metal ion;
a two ended second hydrophobic group; and
a hydrophilic group with first and second end, with the first end covalently linked at the first end of the second hydrophobic group.
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Abstract
This disclosure relates to compositions for delivering agents to a subject, and in particular, to compositions for delivery of therapeutic agents or diagnostic agents in the presence or absence of targeting moieties. In part, this disclosure relates to compositions comprising a hydrophobic group with a first end and a second end, a first metal binding domain linked to the hydrophobic group, a metal ion capable of being chelated to the first metal binding domain, and an agent linked to a second metal binding domain capable of chelating to the metal ion.
227 Citations
27 Claims
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1. A composition with a metal bridge comprising:
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a first hydrophobic group with a first metal binding domain (FMBD) at one end;
a metal ion chelated to the FMBD;
an active agent with a second metal binding domain (SMBD) chelated to the said metal ion;
a two ended second hydrophobic group; and
a hydrophilic group with first and second end, with the first end covalently linked at the first end of the second hydrophobic group. - View Dependent Claims (2, 3, 4, 5, 6, 7, 16, 17, 18, 20, 21, 22, 23, 24, 25, 26)
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8. A composition with a metal bridge comprising:
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a two ended first hydrophobic group with a FMBD covalently linked to the first end;
a metal ion chelated to the FMBD;
an active agent with a second MBD chelated to the said metal ion;
a hydrophilic group with first and second end, with the first end covalently linked at the second end of the said hydrophobic group. - View Dependent Claims (9, 10, 11, 12, 13, 14, 19)
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15. A composition comprising:
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a hydrophobic group;
a hydrophilic group with two ends covalently linked to hydrophobic group at first end;
a FMBD covalently linked to the second end of the hydrophilic group;
a metal ion chelated to the FMBD;
and an active agent with a SMBD chelated to the said metal ion.
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27. A method of providing active agent to a patient in need comprising:
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administration of a composition comprising;
a hydrophobic group with a first metal binding domain (MBD) at one end;
a metal ion chelated to the first MBD; and
an active agent with a second MBD chelated to the said metal ion;
wherein the first or second MBD comprises a nitrogen containing poly carboxylic acid or a polypeptide capable of chelating metal ion, wherein the metal ion is a transition metal ion, wherein the active agent is a metal binding diagnostic imaging agent or a metal binding therapeutic agent, wherein after administration of the composition to a patient, the therapeutic agent is released in a sustained manner.
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Specification