Systems and methods for ex vivo organ care
First Claim
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1. A method for perfusing a lung ex vivo, comprising:
- connecting the lung within a fluid perfusion circuit, flowing a perfusion fluid into the lung through a pulmonary artery interface and away from the lung through a pulmonary vein interface, providing a respiratory gas to the lung for use in metabolism by the lung, the respiratory gas having a pre-determined composition of oxygen, and ventilating the lung through a tracheal interface, wherein the perfusion fluid flowing into the lung includes a first gas component at a substantially constant first composition, and the perfusion fluid flowing away from the lung includes the first gas component at a substantially constant second composition.
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Abstract
The invention, in various embodiments, provides systems, methods and solutions using an organ ex vivo.
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Citations
132 Claims
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1. A method for perfusing a lung ex vivo, comprising:
connecting the lung within a fluid perfusion circuit, flowing a perfusion fluid into the lung through a pulmonary artery interface and away from the lung through a pulmonary vein interface, providing a respiratory gas to the lung for use in metabolism by the lung, the respiratory gas having a pre-determined composition of oxygen, and ventilating the lung through a tracheal interface, wherein the perfusion fluid flowing into the lung includes a first gas component at a substantially constant first composition, and the perfusion fluid flowing away from the lung includes the first gas component at a substantially constant second composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A lung care system comprising:
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a portable multiple use module including a portable chassis;
a single use disposable module including, a disposable structure sized and shaped for interlocking the single use disposable module with the multiple use module for electromechanical inter-operation with the multiple use module, and a lung chamber assembly having a first interface for allowing a flow of the perfusion fluid into the lung, a second interface for allowing ventilation of the lung, and a third interface for allowing a flow of the perfusion fluid away from the lung;
a pump adapted to flow the perfusion fluid into and away from the lungs; and
a respiratory gas source having a predetermined composition of oxygen. - View Dependent Claims (50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76)
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77. A method for evaluating a lung for transplant suitability comprising:
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positioning the lung in an ex vivo perfusion circuit, flowing a perfusion fluid into the lung through a pulmonary artery interface and flowing the perfusion fluid away from the lung through a pulmonary vein interface, the perfusion fluid being at a physiologic temperature, providing a gas to the lung through a tracheal interface, measuring a first composition of a gas component in the perfusion fluid, and performing an evaluation on the lung based on the first composition. - View Dependent Claims (78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98)
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- 99. A composition for use in a solution for perfusing a lung, comprising one or more carbohydrates that include dextran, and a plurality of amino acids that do not include asparagine, glutamine, or cysteine.
Specification