Integrated Lancing and Measurement Device
First Claim
1. A device to determine the concentration of glucose in blood from a patient, comprising:
- a piercing member adapted to pierce and retract from a site on the patient to cause blood to flow therefrom;
a sensor adapted to receive the blood flowing from the site to generate an electrical signal indicative of the concentration of glucose in the blood, the sensor and the piercing member forming an integrated unit, the sensor being detachable from the integrated unit, the sensor comprising a working electrode with a glucose-responsive enzyme in communication with a sample receiving area of the sensor having a volume of less than about 1 μ
l; and
a glucose monitor operatively connected to the sensor and adapted to measure the signal generated by the sensor.
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Accused Products
Abstract
An integrated lancing and measurement device is provided comprising a sensor designed to determine the amount and/or concentration of analyte in a biological fluid having a volume of less than about 1 μL. A piercing member is adapted to pierce and retract from a site on the patient to cause the fluid to flow therefrom, and the sensor is positioned adjacent to the site on the patient so as to receive the fluid flowing from the site to generate an electrical signal indicative of the concentration of the analyte in the fluid. The sensor is comprised of a working electrode comprising an analyte-responsive enzyme and a redox mediator, and a counter electrode. An analyte monitor is operatively connected to the sensor and adapted to measure the signal generated by the sensor. Also provided are analyte measuring methods that optionally employ the integrated lancing and measurement device.
782 Citations
20 Claims
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1. A device to determine the concentration of glucose in blood from a patient, comprising:
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a piercing member adapted to pierce and retract from a site on the patient to cause blood to flow therefrom;
a sensor adapted to receive the blood flowing from the site to generate an electrical signal indicative of the concentration of glucose in the blood, the sensor and the piercing member forming an integrated unit, the sensor being detachable from the integrated unit, the sensor comprising a working electrode with a glucose-responsive enzyme in communication with a sample receiving area of the sensor having a volume of less than about 1 μ
l; and
a glucose monitor operatively connected to the sensor and adapted to measure the signal generated by the sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An integrated sample acquisition and analyte measurement device to determine the concentration of glucose in blood from a patient, comprising:
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a sample acquisition means for producing a patient sample;
a sensor adapted to receive the blood flowing from the site to generate an electrical signal indicative of the concentration of glucose in the blood, the sensor and the piercing member forming an integrated unit, the sensor being detachable from the integrated unit, the sensor comprising a working electrode with a glucose-responsive enzyme in communication with a sample receiving area of the sensor having a volume of less than about 1 μ
l; and
a glucose monitor operatively connected to the sensor and adapted to measure the signal generated by the sensor. - View Dependent Claims (18, 19, 20)
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Specification