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GLOBAL MODEL FOR OPTIMIZING CROSSFLOW MICROFILTRATION AND ULTRAFILTRATION PROCESSES

  • US 20080017576A1
  • Filed: 06/08/2007
  • Published: 01/24/2008
  • Est. Priority Date: 06/15/2006
  • Status: Abandoned Application
First Claim
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1. A method for determining optimum operating conditions for yield of a target species, purity of a target species, selectivity of a target species and/or processing time for crossflow membrane filtration of a polydisperse feed suspension comprising one or more target solute or particle species, said method comprising:

  • providing as input parameters;

    size distribution of the particles and solutes in the suspension, concentration of particles and solutes in the suspension, suspension pH and temperature, membrane thickness, membrane hydraulic permeability (Lp), membrane pore size or molecular weight cut off, membrane module internal diameter, membrane module length, membrane area, membrane porosity, filtration system configuration, and reservoir volume (V);

    determining effective membrane pore size distribution (λ



    ), viscosity of the suspension, hydrodynamics of the suspension, electrostatics of the suspension, pressure-independent permeation flux (JPD) of the suspension and cake composition, pressure-independent permeation flux [JPI(i)] for each particle (i) in the suspension, and overall observed sieving coefficient of each target solute or particle species through cake deposit and pores of the membrane using said provided input parameters;

    solving a solute mass balance equation for each target species in each reservoir of the feed suspension based on said provided size distribution of the particles and solutes in the suspension, concentration of particles and solutes in the suspension, suspension pH and temperature, membrane thickness, membrane hydraulic permeability, membrane pore size or molecular weight cut off, membrane module internal diameter, membrane module length, membrane area, membrane porosity, filtration system configuration, and reservoir volumes, and said determined effective membrane pore size distribution (λ



    ), viscosity of the suspension, hydrodynamics of the suspension, electrostatics of the suspension, pressure-independent permeation flux (JPD) of the suspension and cake composition, pressure-independent permeation flux [JPI(i)] for each particle (i) in the suspension, and overall observed sieving coefficient of a particle through cake deposit and pores of the membrane; and

    iterating the solute mass balance equation for each species at all possible permeation fluxes to determine purity, yield, selectivity, and/or processing time of crossflow filtration of the target species, thereby determining operating conditions that optimize for yield of a target species, selectivity of a target species, purity of a target species, and/or processing time for crossflow membrane filtration of a polydisperse feed suspension comprising one or more target solute or particle species.

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