THERAPEUTIC IMPLANT
First Claim
1. An implant, adapted for insertion in a mammalian body cavity, for use in selectively removing from a body fluid and immobilizing on said implant, at least one known target selected from pathogenic factors, antigens and antigenic determinants, including cells and cell fragments which are at least in part cancerous or pathogenically infected, wherein said implant comprises a surface layer including at least one moiety selected from antibodies and fragments thereof, which specifically bind to said at least one known target, and wherein said implant comprises a biologically compatible substrate, to which said at least one moiety is bound by a ligand in said surface layer.
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Abstract
The invention relates an implant, which comprises a biologically compatible substrate, to which at least one moiety is bound by a ligand, the moiety being one which specifically binds to and selectively immobilizes, at least one known target present in body fluid. The moiety traps the target and thus enables undesired materials present in a body fluid to be destroyed locally in situ, or alternatively to be removed and destroyed ex vivo. A method for selectively removing from a mammalian body fluid in situ, at least one known target, also forms part of the invention.
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Citations
28 Claims
- 1. An implant, adapted for insertion in a mammalian body cavity, for use in selectively removing from a body fluid and immobilizing on said implant, at least one known target selected from pathogenic factors, antigens and antigenic determinants, including cells and cell fragments which are at least in part cancerous or pathogenically infected, wherein said implant comprises a surface layer including at least one moiety selected from antibodies and fragments thereof, which specifically bind to said at least one known target, and wherein said implant comprises a biologically compatible substrate, to which said at least one moiety is bound by a ligand in said surface layer.
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6. A method for selectively removing from a mammalian body fluid in situ, at least one known target, which comprises the following steps (A) and either (B) or (C), namely:
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(A) exposing to said body fluid in a cavity of said mammalian body, an implant inserted in said cavity, wherein said implant comprises a surface layer including at least one moiety which specifically binds to and thus immobilizes said at least one known target, and wherein said implant comprises a biologically compatible substrate, to which said at least one moiety is bound by a ligand in said surface layer; and
, after a predetermined time interval,either (B) removing from said mammalian body cavity, said implant including said at least one target which is bound to said at least one moiety, and in an optional further step, destroying ex-vivo said at least one target bound to said at least one moiety;
or (C) destroying in situ said at least one target bound to said at least one moiety. - View Dependent Claims (7, 8, 9, 10, 11)
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- 12. An implant for use in selectively removing from a mammalian body fluid and immobilizing on said implant, at least one known target selected from pathogenic factors, antigens and antigenic determinants, including cells and cell fragments which are at least in part cancerous or pathogenically infected, wherein said implant comprises a surface layer including at least one moiety selected from antibodies and fragments thereof, which specifically bind to said at least one known target, and comprises also a biologically compatible substrate, to which said at least one moiety is bound by a ligand in said surface layer, said implant being either adapted for suspension within the internal hollow space of an intra-luminal stent, or being suspended within the internal hollow space of an intra-luminal stent prior to insertion of the stent together with its suspended implant in the mammalian body.
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17. A method for selectively removing from a mammalian body fluid in situ, at least one known target, which comprises the following steps (A) and either (B) or (C), namely:
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(A) exposing to said body fluid in the internal hollow space of an intra-luminal stent, an implant suspended in said internal hollow space, wherein said implant comprises a surface layer including at least one moiety which specifically binds to and thus immobilizes said at least one known target, and wherein said implant comprises a biologically compatible substrate, to which said at least one moiety is bound by a ligand in said surface layer; and
, after a predetermined time interval,either (B) removing from said mammalian body said implant either with or without said intra-luminal stent, said implant including said at least one target which is bound to said at least one moiety, and in an optional further step, destroying ex-vivo said at least one target bound to said at least one moiety;
or (C) destroying in situ said at least one target bound to said at least one moiety. - View Dependent Claims (18, 19, 20, 21, 22)
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25-27. -27. (canceled)
Specification