BIOMARKERS FOR USE IN THE DIAGNOSIS AND TREATMENT OF COLORECTAL CANCER
First Claim
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1. A method for diagnosing colorectal cancer in a subject comprising:
- (a) obtaining a biological sample from the subject;
(b) detecting a quantity, presence, or absence of one or more of biomarkers M1, M2, M3, M4, M5, or M6 in said sample;
(c) classifying said subject as having or not having colorectal cancer, based on said quantity, presence, or absence of said biomarkers.
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Abstract
The present invention relates to the field of the diagnosis of large intestine diseases. More particularly, embodiments of the invention provide a method for differential diagnosis of colorectal cancer from a non-malignant disease of the large intestine, and from a healthy large intestine.
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Citations
28 Claims
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1. A method for diagnosing colorectal cancer in a subject comprising:
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(a) obtaining a biological sample from the subject; (b) detecting a quantity, presence, or absence of one or more of biomarkers M1, M2, M3, M4, M5, or M6 in said sample; (c) classifying said subject as having or not having colorectal cancer, based on said quantity, presence, or absence of said biomarkers. - View Dependent Claims (2, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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3. A method for differential diagnosis of colorectal cancer and non-malignant disease of the large intestine in a subject, comprising:
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(a) obtaining a biological sample from the subject; (b) detecting a quantity, presence, or absence of one or more of biomarkers M1, M2, M3, M4, M5, and M6 in said sample; (c) classifying said subject as having colorectal cancer, as having non-malignant disease of the large intestine, or as healthy, based on the quantity, presence, or absence of one or more said biomarkers in said biological sample. - View Dependent Claims (4)
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15. A database containing a plurality of database entries useful in diagnosing subjects as having or not having colorectal cancer, comprising:
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(a) a categorization of each database entry as either characteristic of having or not having colorectal cancer; (b) a characterisation of each database entry as either having, not having, or having in a certain quantity, a biomarker selected from the group consisting of biomarker M1, M2, M3, M4, M5, and M6.
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16. A database generated by:
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(a) obtaining reference biological samples from subjects known to have, and patients known not to have, colorectal cancer; (b) contacting the reference biological samples in (a) with a biologically active surface; (c) allowing biomarkers within the reference biological samples to bind to the biologically active surface; (d) detecting bound biomarkers using a detection method wherein the detection method generates mass profiles of said reference biological samples; (e) transforming the mass profiles into a computer readable form; and (f) applying a mathematical algorithm to classify the mass profiles in (d) as specific for healthy subjects or subjects having colorectal cancer.
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27. A method for determining the stage of colorectal cancer in a subject comprising:
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(a) obtaining a biological sample from the subject (b) detecting the quantity of one or more of biomarkers M1, M2, M3, M4, M5 or M6 in said sample (c) classifying said subject as having stage 0 or stage I or stage IIA or stage IIB or stage IIIA or stage IIIB or stage IIIC or stage IV colorectal cancer - View Dependent Claims (28)
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Specification