METHODS AND SYSTEMS FOR OPTICAL IMAGING OR EPITHELIAL LUMINAL ORGANS BY BEAM SCANNING THEREOF

• US 20080021275A1
• Filed: 01/19/2007
• Published: 01/24/2008
• Est. Priority Date: 01/19/2006
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Vakoc, Benjamin, Nishioka, Norman, Shishkov, Milen, Tearney, Guillermo, Bouma, Brett
• Granted Patent: US 9,087,368 B2
• Time in Patent Office: Days
• US Class Current: 600/115
• CPC Class Codes: A61B 5/0062 Arrangements for scanning
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0068 Confocal scanning
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/7271 Specific aspects of physiological measurement analysis A61B5/316, A61B5/349 and A61B5/374 take precedence
• CPC Class Codes: G06T 2207/10056 Microscopic image
• CPC Class Codes: G06T 2207/10101 Optical tomography; Optical coherence tomography [OCT]
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement can be configured to transceive at least one electromagnetic (e.g., visible) radiation to and from the portion. A second arrangement may be provided at least partially enclosing the first arrangement. Further, a third arrangement can be configured to be actuated so as to position the first arrangement at a predetermined location within the luminal or hollow sample. The first arrangement may be configured to compensate for at least one aberration (e.g., astigmatism) caused by the second arrangement and/or the third arrangement. The second arrangement can include at least one portion which enables a guiding arrangement to be inserted there through. Another arrangement can be provided which is configured to measure a pressure within the at least one portion. The data may include a position and/or an orientation of the first arrangement with respect to the luminal or hollow sample.

Claims

1. An apparatus for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion;

a second arrangement at least partially enclosing the first arrangement; and

a third arrangement which is configured to be actuated so as to position the first arrangement at a predetermined location within the at least one luminal or hollow sample,

wherein the first arrangement is configured to compensate for at least one aberration caused by at least one of the second arrangement or the third arrangement.

2. The apparatus according to claim 1, wherein the at least one aberration is an astigmatism.

3. The apparatus according to claim 1, wherein the apparatus is insertable via at least one of a mouth or a nose of a patient.

4. The apparatus according to claim 1, wherein the first arrangement includes at least one cylindrical surface which is configured to compensate for the at least one aberration.

5. The apparatus according to claim 1, wherein the first arrangement includes at least one ellipsoidal ball lens which is configured to compensate for the at least one aberration.

6. The apparatus according to claim 1, wherein the third arrangement includes a balloon.

7. The apparatus according to claim 6, wherein the balloon is capable of being filled with at least one of a gas or a liquid.

8. The apparatus according to claim 1, wherein the second arrangement includes at least one portion which enables a guiding arrangement to be inserted there through.

9. The apparatus according to claim 1, further comprising a further arrangement which is configured to measure a pressure within the at least one portion

10. The apparatus according to claim 1, wherein the data includes at least one of a position or an orientation of the first arrangement with respect to the at least one luminal or hollow sample.

11. The apparatus according to claim 1, wherein the at least one electromagnetic radiation is visible.

12. The apparatus according to claim 1, wherein the first arrangement includes a section which directs the at least one electromagnetic radiation toward the at least one portion, and obtains the data.

13. The apparatus according to claim 1, wherein the apparatus is capable of being swallowed.

14. The apparatus according to claim 1, wherein the first optical arrangement is configured to transceive at least one first electromagnetic radiation to and from the at least one portion, and transmit at least one second electromagnetic radiation so as to produce a structural change in the at least one portion.

15. The apparatus according to claim 14, further comprising a further arrangement at least partially enclosing the second arrangement, and capable of extending to a position spatially outside a periphery of the section of the first arrangement.

16. The apparatus according to claim 1, further comprising a further apparatus which is configured to receive and record the data and a position and a rotational angle of the first arrangement with respect to the at least one sample.

17. The apparatus according to claim 16, wherein the further arrangement includes a scanning arrangement, the further arrangement detecting the position and the rotation angle by digital counting of encoder signals obtained from the scanning arrangement during at least one scan of the at least one sample.

18. The apparatus according to claim 16, further comprising an additional arrangement which is configured to receive the position and the rotational angle, and generate at least one image associated with the at least one portion using the position and the rotational angle.

19. The apparatus according to claim 18, wherein the additional arrangement is further configured to correct at least one spatial distortion of the at least one image.

20. The apparatus according to claim 1, further comprising a processing arrangement which is capable of being controlled to receive a plurality of images of the at least one sample during at least two axial translations of the first arrangement with respect to the at least one sample, wherein each of the axial translations is provide at a rotational angle.

21. The apparatus according to claim 1, wherein the data is interferometric data associated with the at least one sample.

22. The apparatus according to claim 21, wherein the interferometric data is at least one of spectral-domain optical coherence tomography data, time-domain optical coherence tomography data or optical frequency domain imaging data.

60. The apparatus according to claim 11, wherein the fourth arrangement includes a balloon which is capable of being inflated via a channel extending between the second and third arrangements.

23. An apparatus for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion;

a second arrangement at least partially enclosing the first arrangement, and including at least one portion which enables a guiding arrangement to be inserted there through; and

a third arrangement which is configured to be actuated so as to position the first arrangement at a predetermined location within the at least one luminal or hollow sample.

24. The apparatus according to claim 23, wherein the apparatus is insertable via at least one of a mouth or nose of a patient.

25. The apparatus according to claim 23, further comprising a further apparatus which is configured to receive and record the data and a position and a rotational angle of the first arrangement with respect to the at least one sample.

26. The apparatus according to claim 25, wherein the further arrangement includes a scanning arrangement, the further arrangement detecting the position and the rotation angle by digital counting of encoder signals obtained from the scanning arrangement during at least one scan of the at least one sample.

27. The apparatus according to claim 25, further comprising an additional arrangement which is configured to receive the position and the rotational angle, and generate at least one image associated with the at least one portion using the position and the rotational angle.

28. The apparatus according to claim 27, wherein the additional arrangement is further configured to correct at least one spatial distortion of the at least one image.

29. The apparatus according to claim 23, further comprising a processing arrangement which is capable of being controlled to receive a plurality of images of the at least one sample during at least two axial translations of the first arrangement with respect to the at least one sample, wherein each of the axial translations is provide at a rotational angle.

30. The apparatus according to claim 23, wherein the data is interferometric data associated with the at least one sample.

31. The apparatus according to claim 30, wherein the interferometric data is at least one of spectral-domain optical coherence tomography data, time-domain optical coherence tomography data or optical frequency domain imaging data.

32. An apparatus for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion; and

a second arrangement including at least one non-inflatable portion which is configured to be actuated so as to position the first arrangement at a predetermined location within the at least one luminal or hollow sample.

33. The apparatus according to claim 32, wherein the apparatus is insertable via at least one of a mouth or nose of a patient.

34. The apparatus according to claim 32, wherein the at least one non-inflatable portion is an expandable collapsible basket.

35. The apparatus according to claim 32, further comprising a further apparatus which is configured to receive and record the data and a position and a rotational angle of the first arrangement with respect to the at least one sample.

36. The apparatus according to claim 35, wherein the further arrangement includes a scanning arrangement, the further arrangement detecting the position and the rotation angle by digital counting of encoder signals obtained from the scanning arrangement during at least one scan of the at least one sample.

37. The apparatus according to claim 35, further comprising an additional arrangement which is configured to receive the position and the rotational angle, and generate at least one image associated with the at least one portion using the position and the rotational angle.

38. The apparatus according to claim 37, wherein the additional arrangement is further configured to correct at least one spatial distortion of the at least one image.

39. The apparatus according to claim 32, further comprising a processing arrangement which is capable of being controlled to receive a plurality of images of the at least one sample during at least two axial translations of the first arrangement with respect to the at least one sample, wherein each of the axial translations is provide at a rotational angle.

40. The apparatus according to claim 32, wherein the data is interferometric data associated with the at least one sample.

41. The apparatus according to claim 40, wherein the interferometric data is at least one of spectral-domain optical coherence tomography data, time-domain optical coherence tomography data or optical frequency domain imaging data.

42. An apparatus for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion; and

a second arrangement which is configured to measure a pressure within the at least one portion.

43. The apparatus according to claim 42, further comprising a second arrangement which is configured to be actuated so as to position the first arrangement at a predetermined location within the at least one sample.

44. The apparatus according to claim 42, wherein the apparatus is insertable via at least one of a mouth or nose of a patient.

45. The apparatus according to claim 42, wherein the second arrangement includes a manometer.

46. The apparatus according to claim 42, further comprising a further apparatus which is configured to receive and record the data and a position and a rotational angle of the first arrangement with respect to the at least one sample.

47. The apparatus according to claim 46, wherein the further arrangement includes a scanning arrangement, the further arrangement detecting the position and the rotation angle by digital counting of encoder signals obtained from the scanning arrangement during at least one scan of the at least one sample.

48. The apparatus according to claim 46, further comprising an additional arrangement which is configured to receive the position and the rotational angle, and generate at least one image associated with the at least one portion using the position and the rotational angle.

49. The apparatus according to claim 48, wherein the additional arrangement is further configured to correct at least one spatial distortion of the at least one image.

50. The apparatus according to claim 43, further comprising a processing arrangement which is capable of being controlled to receive a plurality of images of the at least one sample during at least two axial translations of the first arrangement with respect to the at least one sample, wherein each of the axial translations is provide at a rotational angle.

51. The apparatus according to claim 43, wherein the data is interferometric data associated with the at least one sample.

52. The apparatus according to claim 51, wherein the interferometric data is at least one of spectral-domain optical coherence tomography data, time-domain optical coherence tomography data or optical frequency domain imaging data.

53. An apparatus for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion; and

a second arrangement which is configured to be actuated so as to position the first arrangement at a predetermined location within the at least one luminal or hollow sample,

wherein the data includes at least one of a position or an orientation of the first arrangement with respect to the at least one luminal or hollow sample.

54. The apparatus according to claim 53, wherein the apparatus is insertable via at least one of a mouth or nose of a patient.

55. An apparatus for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

a first optical arrangement configured to transceive at least one visible electromagnetic radiation to and from the at least one portion; and

a second arrangement which is configured to be actuated so as to position the first arrangement at a predetermined location within the at least one luminal or hollow sample.

56. An apparatus for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

a first optical arrangement configured to transceive at least one first electromagnetic radiation to and from the at least one portion, and transmit at least one second electromagnetic radiation so as to produce a structural change in the at least one portion; and

a second arrangement which is configured to be actuated so as to position the first arrangement at a predetermined location within the at least one luminal or hollow sample.

57. An apparatus which is capable of being swallowed for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion; and

a second arrangement which is configured to be actuated so as to position the first arrangement at a predetermined location within the at least one luminal or hollow sample.

58. An apparatus which is capable of being swallowed for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion; and

a second arrangement which is configured to forward at least one return radiation from the at least one luminal or hollow sample to an optical coherence tomography system.

59. An apparatus for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

a first optical arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion, and including a section which directs the at least one electromagnetic radiation toward the at least one portion, and obtains the data;

a second arrangement at least partially enclosing the first arrangement;

a third arrangement at least partially enclosing the second arrangement, and capable of extending to a position spatially outside a periphery of the section of the first arrangement; and

a fourth arrangement which is configured to be actuated so as to position the first arrangement at a predetermined location within the at least one luminal or hollow sample.

61. An apparatus for obtaining data for at least one portion within at least one luminal or hollow sample, comprising:

an optical arrangement configured to transceive at least one electromagnetic radiation to and from the at least one portion, the optical arrangement including a section which directs the at least one electromagnetic radiation toward the at least one portion and obtains the data, and an actuating arrangement controlling at least one of a longitudinal translation or a rotation of the section in the optical arrangement, wherein the actuating arrangement is provided proximally with respect to the section, and wherein the actuating arrangement is positioned within or in a proximity of the at least one luminal or hollow sample.

62. The apparatus according to claim 61, further comprising:

a second arrangement at least partially enclosing the first arrangement; and

a third arrangement which is configured to be actuated so as to position the first arrangement at a predetermined location within the at least one luminal or hollow sample.

63. The apparatus according to claim 62, further comprising at least one fourth arrangement which is configured to determine at least one of a rotational angle or a position of the at least one electromagnetic radiation directed toward the at least one portion with respect to the at least one portion.

64. The apparatus according to claim 62, wherein the actuating arrangement is a motor.